Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor [0.03%]
激动剂结合的G蛋白偶联受体与G蛋白耦合的机制研究
Hossein Batebi,Guillermo Pérez-Hernández,Sabrina N Rahman et al.
Hossein Batebi et al.
G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by promoting guanine nucleotide exchange. Here, we investigate the coupling of G proteins with GPCRs and describe the events that ultimately lead to the ejection of GDP ...
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis [0.03%]
PRDX6通过促进硒的利用来限制铁毒性和铁死亡发生
Hiroaki Fujita,Yu-Ki Tanaka,Seiryo Ogata et al.
Hiroaki Fujita et al.
Ferroptosis is a form of regulated cell death induced by iron-dependent accumulation of lipid hydroperoxides. Selenoprotein glutathione peroxidase 4 (GPX4) suppresses ferroptosis by detoxifying lipid hydroperoxides via a catalytic selenocys...
Author Correction: Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT3 receptors [0.03%]
作者更正：抗抑郁药沃西汀在人类和rodent5-ht3受体处活性的结构决定因素
Uriel López-Sánchez,Lachlan Jake Munro,Lucy Kate Ladefoged et al.
Uriel López-Sánchez et al.
Published Erratum
Nature structural & molecular biology. 2024 Jul;31(7):1145. DOI:10.1038/s41594-024-01346-y 2024
The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA [0.03%]
人类80S核糖体的结构揭示了化学修饰和离子在RNA中的分子作用
Samuel Holvec,Charles Barchet,Antony Lechner et al.
Samuel Holvec et al.
The ribosomal RNA of the human protein synthesis machinery comprises numerous chemical modifications that are introduced during ribosome biogenesis. Here we present the 1.9 Å resolution cryo electron microscopy structure of the 80S human r...
Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease [0.03%]
小型异染色质区室限制SVA转座子在人类大脑发育和疾病中的顺式调控作用
Vivien Horváth,Raquel Garza,Marie E Jönsson et al.
Vivien Horváth et al.
SVA (SINE (short interspersed nuclear element)-VNTR (variable number of tandem repeats)-Alu) retrotransposons remain active in humans and contribute to individual genetic variation. Polymorphic SVA alleles harbor gene regulatory potential a...
W Dylan Hale,Alejandra Montaño Romero,Cuauhtemoc U Gonzalez et al.
W Dylan Hale et al.
Excitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype ionotropic glutamate receptors (AMPARs). Negative allosteric modulators are therapeutic candidates that inhibit AMP...
Jagan Mohan,Satish B Moparthi,Christine Girard-Blanc et al.
Jagan Mohan et al.
The hallmark of non-selective autophagy is the formation of cup-shaped phagophores that capture bulk cytoplasm. The process is accompanied by the conjugation of LC3B to phagophores by an E3 ligase complex comprising ATG12-ATG5 and ATG16L1. ...
XIST dampens X chromosome activity in a SPEN-dependent manner during early human development [0.03%]
SPEN依赖的XIST调节早期人类胚胎中外 Xm 区域基因表达降级的作用机制研究
Charbel Alfeghaly,Gaël Castel,Emmanuel Cazottes et al.
Charbel Alfeghaly et al.
XIST (X-inactive specific transcript) long noncoding RNA (lncRNA) is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female preimplantation embryos without triggering X...