Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD [0.03%]
NAP1和SINTBAD通过TBK1调控自噬体介导的线粒体自噬起始及发生
Elias Adriaenssens,Thanh Ngoc Nguyen,Justyna Sawa-Makarska et al.
Elias Adriaenssens et al.
Mitophagy preserves overall mitochondrial fitness by selectively targeting damaged mitochondria for degradation. The regulatory mechanisms that prevent PTEN-induced putative kinase 1 (PINK1) and E3 ubiquitin ligase Parkin (PINK1/Parkin)-dep...
Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16 [0.03%]
单结构域去泛素化酶USP16催化组蛋白H2A第119位赖氨酸脱泛素化的结构与机制研究
Huasong Ai,Zaozhen He,Zhiheng Deng et al.
Huasong Ai et al.
Epigenetic regulators have a crucial effect on gene expression based on their manipulation of histone modifications. Histone H2AK119 monoubiquitination (H2AK119Ub), a well-established hallmark in transcription repression, is dynamically reg...
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase [0.03%]
结合丝氨酸琥珀酸tRNA合成酶的m3C RNA甲基转移酶METTL6在识别tRNA中的结构基础
Philipp Throll,Luciano G Dolce,Palma Rico-Lastres et al.
Philipp Throll et al.
Methylation of cytosine 32 in the anticodon loop of tRNAs to 3-methylcytosine (m3C) is crucial for cellular translation fidelity. Misregulation of the RNA methyltransferases setting this modification can cause aggressive cancers and metabol...
Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro [0.03%]
XLF和XRCC4的无序区域通过多价相互作用增强细胞NHEJ并在体外促进形成补缀强化凝聚物
Duc-Duy Vu,Alessio Bonucci,Manon Brenière et al.
Duc-Duy Vu et al.
In mammalian cells, DNA double-strand breaks are predominantly repaired by non-homologous end joining (NHEJ). During repair, the Ku70-Ku80 heterodimer (Ku), X-ray repair cross complementing 4 (XRCC4) in complex with DNA ligase 4 (X4L4) and ...
Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants [0.03%]
抗惊厥药物与突触小泡蛋白2A和2B的复合物结构
Anshumali Mittal,Matthew F Martin,Elena J Levin et al.
Anshumali Mittal et al.
Epilepsy is a common neurological disorder characterized by abnormal activity of neuronal networks, leading to seizures. The racetam class of anti-seizure medications bind specifically to a membrane protein found in the synaptic vesicles of...
Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms [0.03%]
多种状态下Smc5/6的冷冻电镜结构揭示其组装和功能机制
Qian Li,Jun Zhang,Cory Haluska et al.
Qian Li et al.
Smc5/6 is a member of the eukaryotic structural maintenance of chromosomes (SMC) family of complexes with important roles in genome maintenance and viral restriction. However, limited structural understanding of Smc5/6 hinders the elucidati...
Fasséli Coulibaly
Fasséli Coulibaly
Structural basis for the dynamic chaperoning of disordered clients by Hsp90 [0.03%]
Hsp90通过动态分子构象为无序客户蛋白提供分子伴侣作用的结构基础
Xiaozhan Qu,Shuo Zhao,Chanjuan Wan et al.
Xiaozhan Qu et al.
Molecular chaperone heat shock protein 90 (Hsp90) is a ubiquitous regulator that fine-tunes and remodels diverse client proteins, exerting profound effects on normal biology and diseases. Unraveling the mechanistic details of Hsp90's functi...
The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader [0.03%]
人类ATAD5进化出独特的结构元件，以PCNA卸载酶的独特功能存在
Feng Wang,Qing He,Nina Y Yao et al.
Feng Wang et al.
Humans have three different proliferating cell nuclear antigen (PCNA) clamp-loading complexes: RFC and CTF18-RFC load PCNA onto DNA, but ATAD5-RFC can only unload PCNA from DNA. The underlying structural basis of ATAD5-RFC unloading is unkn...
Author Correction: MYC phase separation selectively modulates the transcriptome [0.03%]
作者更正：MYC相分离选择性地调节转录组
Junjiao Yang,Chan-I Chung,Jessica Koach et al.
Junjiao Yang et al.
Published Erratum
Nature structural & molecular biology. 2024 Jun 12. DOI:10.1038/s41594-024-01351-1 2024