AlphaFold3 takes a step toward decoding molecular behavior and biological computation [0.03%]
AlphaFold3迈向解码分子行为和生物计算之路
Rohit Roy,Hashim M Al-Hashimi
Rohit Roy
VCP/p97-associated proteins are binders and debranching enzymes of K48-K63-branched ubiquitin chains [0.03%]
VCP/p97相关蛋白结合并降解K48-K63连接的泛素分支链
Sven M Lange,Matthew R McFarland,Frederic Lamoliatte et al.
Sven M Lange et al.
Branched ubiquitin (Ub) chains constitute a sizable fraction of Ub polymers in human cells. Despite their abundance, our understanding of branched Ub function in cell signaling has been stunted by the absence of accessible methods and tools...
Agnel Sfeir
Agnel Sfeir
Cryo-EM structures of γ-TuRC reveal molecular insights into microtubule nucleation [0.03%]
γ-TuRC的低温电镜结构为微管成核提供了分子见解
Léa Mammri,Paul T Conduit
Léa Mammri
cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers [0.03%]
cBAF通过在增强子处生成亚核小体使OCT4的结合和功能超越DNA基序
Marina C Nocente,Anida Mesihovic Karamitsos,Emilie Drouineau et al.
Marina C Nocente et al.
The canonical BRG/BRM-associated factor (cBAF) complex is essential for chromatin opening at enhancers in mammalian cells. However, the nature of the open chromatin remains unclear. Here, we show that, in addition to producing histone-free ...
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis [0.03%]
MALAT1 RNA成熟和mascRNA生物发生的结构基础
Ilias Skeparnias,Charles Bou-Nader,Dimitrios G Anastasakis et al.
Ilias Skeparnias et al.
The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) long noncoding RNA (lncRNA) has key roles in regulating transcription, splicing, tumorigenesis, etc. Its maturation and stabilization require precise processing by RNase P,...
Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy [0.03%]
利用冷冻电子显微镜对细菌RNA聚合酶启动子解旋的早期中间体进行时间分辨可视化研究
Ruth M Saecker,Andreas U Mueller,Brandon Malone et al.
Ruth M Saecker et al.
During formation of the transcription-competent open complex (RPo) by bacterial RNA polymerases (RNAPs), transient intermediates pile up before overcoming a rate-limiting step. Structural descriptions of these interconversions in real time ...
Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing [0.03%]
单碱基平铺屏揭示了PspCas13b的高效无脱靶RNA干扰的设计原则
Wenxin Hu,Amit Kumar,Syed Faraz Ahmed et al.
Wenxin Hu et al.
The development of precise RNA-editing tools is essential for the advancement of RNA therapeutics. CRISPR (clustered regularly interspaced short palindromic repeats) PspCas13b is a programmable RNA nuclease predicted to offer superior speci...
Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly [0.03%]
线粒体Hsp60的不对称顶结构域状态协调底物结合和分子伴侣组装
Julian R Braxton,Hao Shao,Eric Tse et al.
Julian R Braxton et al.
The mitochondrial chaperonin, mitochondrial heat shock protein 60 (mtHsp60), promotes the folding of newly imported and transiently misfolded proteins in the mitochondrial matrix, assisted by its co-chaperone mtHsp10. Despite its essential ...