Poised PABP-RNA hubs implement signal-dependent mRNA decay in development [0.03%]
成熟的PABP-RNA中心通过实施信号依赖性mRNA降解来促进发育
Miha Modic,Klara Kuret,Sebastian Steinhauser et al.
Miha Modic et al.
Signaling pathways drive cell fate transitions largely by changing gene expression. However, the mechanisms for rapid and selective transcriptome rewiring in response to signaling cues remain elusive. Here we use deep learning to deconvolve...
Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs [0.03%]
决定let-7前体microRNA命运的聚合酶活性转换的结构基础
Gangshun Yi,Mingda Ye,Loic Carrique et al.
Gangshun Yi et al.
Tumor-suppressor let-7 pre-microRNAs (miRNAs) are regulated by terminal uridylyltransferases TUT7 and TUT4 that either promote let-7 maturation by adding a single uridine nucleotide to the pre-miRNA 3' end or mark them for degradation by th...
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells [0.03%]
细胞生长导致的基因组稀释驱动哺乳动物和酵母细胞中的饥饿状蛋白质组重塑现象
Michael C Lanz,Shuyuan Zhang,Matthew P Swaffer et al.
Michael C Lanz et al.
Cell size is tightly controlled in healthy tissues and single-celled organisms, but it remains unclear how cell size influences physiology. Increasing cell size was recently shown to remodel the proteomes of cultured human cells, demonstrat...
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase [0.03%]
肺炎链球菌NADPH氧化酶的结构和机理研究展望
Victor R A Dubach,Pablo San Segundo-Acosta,Bonnie J Murphy
Victor R A Dubach
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) have a major role in the physiology of eukaryotic cells by mediating reactive oxygen species production. Evolutionarily distant proteins with the NOX catalytic core have be...
The ribosome termination complex remodels release factor RF3 and ejects GDP [0.03%]
核糖体终止复合物重塑释放因子RF3并将其GDP排出
Li Li,Mariia Yu Rybak,Jinzhong Lin et al.
Li Li et al.
Translation termination involves release factors RF1, RF2 and the GTPase RF3 that recycles RF1 and RF2 from the ribosome. RF3 dissociates from the ribosome in the GDP-bound form and must then exchange GDP for GTP. The 70S ribosome terminati...
Structural basis of NEAT1 lncRNA maturation and menRNA instability [0.03%]
NEAT1长链非编码RNA成熟和men RNA不稳定的结构基础
Ilias Skeparnias,Jinwei Zhang
Ilias Skeparnias
NEAT1 long noncoding RNA orchestrates paraspeckle assembly and impacts tumorigenesis, fertility and immunity. Its maturation requires RNase P cleavage yielding an unstable transfer RNA-like multiple endocrine neoplasia-β tRNA-like transcri...
The power of scientific collaborations and the future of structural biology [0.03%]
科研合作的力量以及结构生物学的未来
Pedro Beltrao
Pedro Beltrao
Elena Lavdovskaia,Elisa Hanitsch,Andreas Linden et al.
Elena Lavdovskaia et al.
Mitochondria contain dedicated ribosomes (mitoribosomes), which synthesize the mitochondrial-encoded core components of the oxidative phosphorylation complexes. The RNA and protein components of mitoribosomes are encoded on two different ge...
Resolving chaperone-assisted protein folding on the ribosome at the peptide level [0.03%]
从肽段水平解析核糖体辅助蛋白质折叠机制
Thomas E Wales,Aleksandra Pajak,Alžběta Roeselová et al.
Thomas E Wales et al.
Protein folding in vivo begins during synthesis on the ribosome and is modulated by molecular chaperones that engage the nascent polypeptide. How these features of protein biogenesis influence the maturation pathway of nascent proteins is i...