Topoisomerase-modulated genome-wide DNA supercoiling domains colocalize with nuclear compartments and regulate human gene expression [0.03%]
拓扑异构酶调节的全基因组DNA超螺旋结构域与核区室共定位并调控人类基因表达
Qian Yao,Linying Zhu,Zhen Shi et al.
Qian Yao et al.
DNA supercoiling is a biophysical feature of the double helix with a pivotal role in biological processes. However, understanding of DNA supercoiling in the chromatin remains limited. Here, we developed azide-trimethylpsoralen sequencing (A...
Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies [0.03%]
细菌ESCRT-III蛋白PspA高阶聚合物中的结构可塑性
Benedikt Junglas,Esther Hudina,Philipp Schönnenbeck et al.
Benedikt Junglas et al.
Eukaryotic members of the endosome sorting complex required for transport-III (ESCRT-III) family have been shown to form diverse higher-order assemblies. The bacterial phage shock protein A (PspA) has been identified as a member of the ESCR...
Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization [0.03%]
质子触发的AMPA受体N端结构域重排影响受体动力学和突触定位
Josip Ivica,Nejc Kejzar,Hinze Ho et al.
Josip Ivica et al.
AMPA glutamate receptors (AMPARs) are ion channel tetramers that mediate the majority of fast excitatory synaptic transmission. They are composed of four subunits (GluA1-GluA4); the GluA2 subunit dominates AMPAR function throughout the fore...
Structural basis of LRPPRC-SLIRP-dependent translation by the mitoribosome [0.03%]
线粒体核糖体依赖的LRPPRC-SLIRP调控的翻译机制及其结构基础
Vivek Singh,J Conor Moran,Yuzuru Itoh et al.
Vivek Singh et al.
In mammalian mitochondria, mRNAs are cotranscriptionally stabilized by the protein factor LRPPRC (leucine-rich pentatricopeptide repeat-containing protein). Here, we characterize LRPPRC as an mRNA delivery factor and report its cryo-electro...
Sex chromosome-encoded protein homologs: current progress and open questions [0.03%]
性染色体编码蛋白同源物：最新进展与悬而未决的问题
Michael C Owens,Amber Yanas,Kathy Fange Liu
Michael C Owens
The complexity of biological sex differences is markedly evident in human physiology and pathology. Although many of these differences can be ascribed to the expression of sex hormones, another contributor to sex differences lies in the sex...
Vadim Molodtsov,Chengyuan Wang,Jing Zhang et al.
Vadim Molodtsov et al.
The NusG paralog RfaH mediates bacterial transcription-translation coupling in genes that contain a DNA sequence element, termed an ops site, required for pausing RNA polymerase (RNAP) and for loading RfaH onto the paused RNAP. Here, we rep...
Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol ε [0.03%]
人类前导链DNA聚合酶Pol ε连续合成子链和校对的结构基础
Johann J Roske,Joseph T P Yeeles
Johann J Roske
During chromosome replication, the nascent leading strand is synthesized by DNA polymerase epsilon (Pol ε), which associates with the sliding clamp processivity factor proliferating cell nuclear antigen (PCNA) to form a processive holoenzy...
Kelli L Hvorecny
Kelli L Hvorecny
The cyanobacterial protein VIPP1 forms ESCRT-III-like structures on lipid bilayers [0.03%]
蓝藻蛋白VIPP1在脂质双层上形成类似ESCRT-III的结构
Sichen Pan,Karin Gries,Benjamin D Engel et al.
Sichen Pan et al.
The biogenesis and maintenance of thylakoid membranes require vesicle-inducing protein in plastids 1 (VIPP1). VIPP1 is a member of the endosomal sorting complex required for transport-III (ESCRT-III) superfamily, whose members form diverse ...