Distinct stabilization of the human T cell leukemia virus type 1 immature Gag lattice [0.03%]
人T细胞白血病病毒Ⅰ型成熟缺陷型Gag衣壳的稳定结构
Martin Obr,Mathias Percipalle,Darya Chernikova et al.
Martin Obr et al.
Human T cell leukemia virus type 1 (HTLV-1) immature particles differ in morphology from other retroviruses, suggesting a distinct way of assembly. Here we report the results of cryo-electron tomography studies of HTLV-1 virus-like particle...
Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis [0.03%]
自身免疫性脑炎介导N-甲基-D-天冬氨酸受体聚集和内吞的结构基础
Han Wang,Chun Xie,Bo Deng et al.
Han Wang et al.
Antibodies against N-methyl-D-aspartate receptors (NMDARs) are most frequently detected in persons with autoimmune encephalitis (AE) and used as diagnostic biomarkers. Elucidating the structural basis of monoclonal antibody (mAb) binding to...
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis [0.03%]
抗N-甲基-D天冬氨酸受体自身免疫性脑炎的结构和功能机制
Kevin Michalski,Taha Abdulla,Sam Kleeman et al.
Kevin Michalski et al.
Autoantibodies against neuronal membrane proteins can manifest in autoimmune encephalitis, inducing seizures, cognitive dysfunction and psychosis. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most dominant autoimmune encep...
Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice [0.03%]
独立于53BP1介导的修复途径选择, Shieldin和CST协同调控DNA聚合酶依赖性的带状末端连接反应
Ashleigh King,Pia I Reichl,Jean S Metson et al.
Ashleigh King et al.
Tumor suppressor p53-binding protein 1 (53BP1) regulates DNA end joining in lymphocytes, diversifying immune antigen receptors. This involves nucleosome-bound 53BP1 at DNA double-stranded breaks (DSBs) recruiting Rap1-interacting factor 1 h...
Structural insight into synergistic activation of human 3-methylcrotonyl-CoA carboxylase [0.03%]
人类3-甲基丁酰辅酶A羧化酶协同激活的结构见解
Jiayue Su,Xuyang Tian,Hang Cheng et al.
Jiayue Su et al.
The enzymes 3-methylcrotonyl-coenzyme A (CoA) carboxylase (MCC), pyruvate carboxylase and propionyl-CoA carboxylase belong to the biotin-dependent carboxylase family located in mitochondria. They participate in various metabolic pathways in...
Yang Wang,Selma Dahmane,Rujuan Ti et al.
Yang Wang et al.
Autophagy is characterized by the formation of double-membrane vesicles called autophagosomes. Autophagy-related proteins (ATGs) 2A and 9A have an essential role in autophagy by mediating lipid transfer and re-equilibration between membrane...
Alperen Yilmaz,Gulben Gurhan,Jacob H Hanna
Alperen Yilmaz
Differential dynamics specify MeCP2 function at nucleosomes and methylated DNA [0.03%]
差异动力学决定MeCP2在核小体和甲基化DNA中的功能
Gabriella N L Chua,John W Watters,Paul Dominic B Olinares et al.
Gabriella N L Chua et al.
Methyl-CpG-binding protein 2 (MeCP2) is an essential chromatin-binding protein whose mutations cause Rett syndrome (RTT), a severe neurological disorder that primarily affects young females. The canonical view of MeCP2 as a DNA methylation-...
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer-promoter communication [0.03%]
位于 dac 基因座的 PRE 环作为一种拓扑结构染色质结构限制和定义增强子与启动子之间的交流
Sandrine Denaud,Marion Bardou,Giorgio-Lucio Papadopoulos et al.
Sandrine Denaud et al.
Three-dimensional (3D) genome folding has a fundamental role in the regulation of developmental genes by facilitating or constraining chromatin interactions between cis-regulatory elements (CREs). Polycomb response elements (PREs) are a spe...