Kei Saotome,Luke L McGoldrick,Jo-Hao Ho et al.
Kei Saotome et al.
Activation of the chemokine receptor CXCR4 by its chemokine ligand CXCL12 regulates diverse cellular processes. Previously reported crystal structures of CXCR4 revealed the architecture of an inactive, homodimeric receptor. However, many st...
Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth [0.03%]
EZH2和REST抑制引起的超级沉默扰动导致染色质互作大量丢失及癌症生长受抑
Ying Zhang,Kaijing Chen,Seng Chuan Tang et al.
Ying Zhang et al.
Human silencers have been shown to regulate developmental gene expression. However, the functional importance of human silencers needs to be elucidated, such as whether they can form 'super-silencers' and whether they are linked to cancer p...
You Yu,Juncheng Wang,Kaixian Liu et al.
You Yu et al.
DNA double-strand breaks that initiate meiotic recombination are formed by the topoisomerase-relative enzyme Spo11, supported by conserved auxiliary factors. Because high-resolution structural data have not been available, many questions re...
Publisher Correction: Structural basis of LRPPRC-SLIRP-dependent translation by the mitoribosome [0.03%]
出版更正：线粒体核糖体依赖LRPPRC-SLIRP进行翻译的结构基础
Vivek Singh,J Conor Moran,Yuzuru Itoh et al.
Vivek Singh et al.
Published Erratum
Nature structural & molecular biology. 2024 Nov;31(11):1809. DOI:10.1038/s41594-024-01402-7 2024
Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis [0.03%]
DNA聚合酶κ在跨损伤DNA合成中的催化和非催化功能
Selene Sellés-Baiget,Sara M Ambjørn,Alberto Carli et al.
Selene Sellés-Baiget et al.
Translesion DNA synthesis (TLS) is a cellular process that enables the bypass of DNA lesions encountered during DNA replication and is emerging as a primary target of chemotherapy. Among vertebrate DNA polymerases, polymerase κ (Polκ) has...
Structural basis for translational control by the human 48S initiation complex [0.03%]
人类48S起始复合物的翻译调控机制及其结构基础
Valentyn Petrychenko,Sung-Hui Yi,David Liedtke et al.
Valentyn Petrychenko et al.
The selection of an open reading frame (ORF) for translation of eukaryotic mRNA relies on remodeling of the scanning 48S initiation complex into an elongation-ready 80S ribosome. Using cryo-electron microscopy, we visualize the key commitme...
Author Correction: Unwinding of a eukaryotic origin of replication visualized by cryo-EM [0.03%]
作者更正：通过冷冻电镜可视化端起始的真核生物复制原点
Sarah S Henrikus,Marta H Gross,Oliver Willhoft et al.
Sarah S Henrikus et al.
Published Erratum
Nature structural & molecular biology. 2024 Nov;31(11):1808. DOI:10.1038/s41594-024-01398-0 2024
Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity [0.03%]
雌激素受体功能对溴结构域抑制作用的抵抗由转录共激活因子互补性介导
Sicong Zhang,Robert G Roeder
Sicong Zhang
The bromodomain and extraterminal domain (BET) family of proteins are critical chromatin readers that bind to acetylated histones through their bromodomains to activate transcription. Here, we reveal that bromodomain inhibition fails to rep...
Exocyst stimulates multiple steps of exocytic SNARE complex assembly and vesicle fusion [0.03%]
exo囊泡刺激多个exoSNARE复合物装配和膜融合步骤
Chanwoo Lee,Dante Lepore,Seung-Hak Lee et al.
Chanwoo Lee et al.
Exocyst is a large multisubunit tethering complex essential for targeting and fusion of secretory vesicles in eukaryotic cells. Although the assembled exocyst complex has been proposed to tether vesicles to the plasma membrane and activate ...
Pseudouridine guides germline small RNA transport and epigenetic inheritance [0.03%]
假尿苷指导生殖细胞小RNA转运及表观遗传继承
Rowan P Herridge,Jakub Dolata,Valentina Migliori et al.
Rowan P Herridge et al.
Developmental epigenetic modifications in plants and animals are mostly reset during gamete formation but some are inherited from the germline. Small RNAs guide these epigenetic modifications but how inherited small RNAs are distinguished i...