George Andrew S Inglis
George Andrew S Inglis
Tanja Kuhm,Clémence Taisne,Cecilia de Agrela Pinto et al.
Tanja Kuhm et al.
Guanylate-binding proteins (GBPs) are interferon-inducible guanosine triphosphate hydrolases (GTPases) mediating host defense against intracellular pathogens. Their antimicrobial activity hinges on their ability to self-associate and coat p...
Structural basis for Vipp1 membrane binding: from loose coats and carpets to ring and rod assemblies [0.03%]
Vipp1膜结合的结构基础：从松散的夹具和地毯到环状和棒状组装体
Benedikt Junglas,David Kartte,Mirka Kutzner et al.
Benedikt Junglas et al.
Vesicle-inducing protein in plastids 1 (Vipp1) is critical for thylakoid membrane biogenesis and maintenance. Although Vipp1 has recently been identified as a member of the endosomal sorting complexes required for transport III superfamily,...
Cryo-EM structure of the human subcortical maternal complex and the associated discovery of infertility-associated variants [0.03%]
人类亚 cortical 母系复合物的冷冻电镜结构及其相关不孕不育相关变异体的发现
Pengliang Chi,Guojin Ou,Sibei Liu et al.
Pengliang Chi et al.
The functionally conserved subcortical maternal complex (SCMC) is essential for early embryonic development in mammals. Reproductive disorders caused by pathogenic variants in NLRP5, TLE6 and OOEP, three core components of the SCMC, have at...
Mesoscale chromatin confinement facilitates target search of pioneer transcription factors in live cells [0.03%]
活细胞中转录因子对染色质结合位点的搜索受小尺度染色质结构调控
Zuhui Wang,Bo Wang,Di Niu et al.
Zuhui Wang et al.
Pioneer transcription factors (PTFs) possess the unique capability to access closed chromatin regions and initiate cell fate changes, yet the underlying mechanisms remain elusive. Here, we characterized the single-molecule dynamics of PTFs ...
Structure of Fanzor2 reveals insights into the evolution of the TnpB superfamily [0.03%]
Fanzor2结构揭示了TnpB超家族的进化规律
Richard D Schargel,M Zuhaib Qayyum,Ajay Singh Tanwar et al.
Richard D Schargel et al.
RNA-guided endonucleases, once thought to be exclusive to prokaryotes, have been recently identified in eukaryotes and are called Fanzors. They are classified into two clades, Fanzor1 and Fanzor2. Here we present the cryo-electron microscop...
Inga V Hochheiser,Matthias Geyer
Inga V Hochheiser
Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity [0.03%]
NORAD长链非编码RNA的结构特征可有效抑制Pumilio活性
Svetlana Farberov,Omer Ziv,Jian You Lau et al.
Svetlana Farberov et al.
Long noncoding RNAs (lncRNAs) are increasingly appreciated for their important functions in mammalian cells. However, how their functional capacities are encoded in their sequences and manifested in their structures remains largely unknown....
Structural insights into translocation and tailored synthesis of hyaluronan [0.03%]
透明质酸转运及精准合成的结构见解
Ireneusz Górniak,Zachery Stephens,Satchal K Erramilli et al.
Ireneusz Górniak et al.
Hyaluronan (HA) is an essential component of the vertebrate extracellular matrix. It is a heteropolysaccharide of N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA) reaching several megadaltons in healthy tissues. HA is synthesized and...