Understanding ubiquitination in neurodevelopment by integrating insights across space and time [0.03%]
整合时间和空间的见解以理解神经发育中的泛素化作用
Mateusz C Ambrozkiewicz,Sonja Lorenz
Mateusz C Ambrozkiewicz
Ubiquitination regulates a myriad of eukaryotic signaling cascades by modifying substrate proteins, thereby determining their functions and fates. In this perspective, we discuss current challenges in investigating the ubiquitin system in t...
Substrate translocation and inhibition in human dicarboxylate transporter NaDC3 [0.03%]
人类二羧酸转运蛋白NaDC3的底物转运和抑制作用研究
Yan Li,Jinmei Song,Vedrana Mikusevic et al.
Yan Li et al.
The human high-affinity sodium-dicarboxylate cotransporter (NaDC3) imports various substrates into the cell as tricarboxylate acid cycle intermediates, lipid biosynthesis precursors and signaling molecules. Understanding the cellular signal...
Supporting structural biologists in Africa requires resources and capacity building [0.03%]
支持非洲结构生物学需要资源和能力培养
Emmanuel Nji,Aurélien F A Moumbock,Katharina C Cramer et al.
Emmanuel Nji et al.
Javier Apfeld
Javier Apfeld
Looking back at the timely launch of Nature Structural Biology in 1994 [0.03%]
回望《自然—结构生物学》创刊于1994年的前前后后
Christian Cambillau
Christian Cambillau
Closed and open structures of the eukaryotic magnesium channel Mrs2 reveal the auto-ligand-gating regulation mechanism [0.03%]
揭示自动配体门控调节机制的真核镁通道Mrs2的开闭结构
Ping Li,Shiyan Liu,Johan Wallerstein et al.
Ping Li et al.
The CorA/Mrs2 family of pentameric proteins are cardinal for the influx of Mg2+ across cellular membranes, importing the cation to mitochondria in eukaryotes. Yet, the conducting and regulation mechanisms of permeation remain elusive, parti...
Zhihui He,Yung-Chi Tu,Chen-Wei Tsai et al.
Zhihui He et al.
The human mitochondrial RNA splicing 2 protein (MRS2) has been implicated in Mg2+ transport across mitochondrial inner membranes, thus having an important role in Mg2+ homeostasis critical for mitochondrial integrity and function. However, ...
A lesson in symmetry [0.03%]
对称性教学
Magdalena Boncler
Magdalena Boncler
Diverse anti-NMDAR autoantibodies from individuals with encephalitis [0.03%]
来自脑炎患者的多种抗N-甲基-D天冬氨酸受体自身抗体
Zoe Jamet,Frederic Villega,Laurent Groc
Zoe Jamet
Michael-Florian Szalay,Blanka Majchrzycka,Ivana Jerković et al.
Michael-Florian Szalay et al.
The genome of all organisms is spatially organized to function efficiently. The advent of genome-wide chromatin conformation capture (Hi-C) methods has revolutionized our ability to probe the three-dimensional (3D) organization of genomes a...