Importance of an N-terminal structural switch in the distinction between small RNA-bound and free ARGONAUTE [0.03%]
N端结构开关在小RNA结合ARGONAUTE与游离ARGONAUTE区分中的重要作用
Simon Bressendorff,Ida Marie Zobbe Sjøgaard,Andreas Prestel et al.
Simon Bressendorff et al.
ARGONAUTE (AGO) proteins bind to small non-coding RNAs to form RNA-induced silencing complexes. In the RNA-bound state, AGO is stable while RNA-free AGO turns over rapidly. Molecular features unique to RNA-free AGO that allow its specific r...
Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications [0.03%]
活性转录组修饰抑制Polycomb Repressive Complex 2的分子机制
Trinity Cookis,Alexandria Lydecker,Paul Sauer et al.
Trinity Cookis et al.
Polycomb repressive complex 2 (PRC2) trimethylates histone H3 on K27 (H3K27me3) leading to gene silencing that is essential for embryonic development and maintenance of cell identity. PRC2 is regulated by protein cofactors and their crossta...
Katarína Tlučková,Beata Kaczmarek,Anita Salmazo et al.
Katarína Tlučková et al.
Transcription by RNA polymerase II (Pol II) can be repressed by noncoding RNA, including the human RNA Alu. However, the mechanism by which endogenous RNAs repress transcription remains unclear. Here we present cryogenic-electron microscopy...
Capture, mutual inhibition and release mechanism for aPKC-Par6 and its multisite polarity substrate Lgl [0.03%]
aPKC-Par6与其多泛素位点极性底物Lgl的捕获、相互抑制和释放机制
Christopher P Earl,Mathias Cobbaut,André Barros-Carvalho et al.
Christopher P Earl et al.
The mutually antagonistic relationship of atypical protein kinase C (aPKC) and partitioning-defective protein 6 (Par6) with the substrate lethal (2) giant larvae (Lgl) is essential for regulating polarity across many cell types. Although aP...
Interfacial water confers transcription factors with dinucleotide specificity [0.03%]
界面对分子具有二核苷酸特异性转录因子的作用
Ekaterina Morgunova,Gabor Nagy,Yimeng Yin et al.
Ekaterina Morgunova et al.
Transcription factors (TFs) recognize specific bases within their DNA-binding motifs, with each base contributing nearly independently to total binding energy. However, the energetic contributions of particular dinucleotides can deviate str...
ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage [0.03%]
ATM和IRAK1在DNA损伤反应中通过两种不同的机制共同调控NF-κB的活化
Elodie Bournique,Ambrocio Sanchez,Sunwoo Oh et al.
Elodie Bournique et al.
DNA damage in cells induces the expression of inflammatory genes. However, the mechanism by which cells initiate an innate immune response in the presence of DNA lesions blocking transcription remains unknown. Here we find that genotoxic st...
Molecular basis of human nuclear and mitochondrial tRNA 3' processing [0.03%]
人类核及线粒体tRNA 3'端加工的分子机制
Arjun Bhatta,Bernhard Kuhle,Ryan D Yu et al.
Arjun Bhatta et al.
Eukaryotic transfer RNA (tRNA) precursors undergo sequential processing steps to become mature tRNAs. In humans, ELAC2 carries out 3' end processing of both nucleus-encoded (nu-tRNAs) and mitochondria-encoded (mt-tRNAs) tRNAs. ELAC2 is self...
KIF1C activates and extends dynein movement through the FHF cargo adapter [0.03%]
KIF1C通过FHF货物适配器激活并延长动力蛋白的运动
Ferdos Abid Ali,Alexander J Zwetsloot,Caroline E Stone et al.
Ferdos Abid Ali et al.
Cellular cargos move bidirectionally on microtubules by recruiting opposite polarity motors dynein and kinesin. These motors show codependence, where one requires the activity of the other, although the mechanism is unknown. Here we show th...
Grace Hohman,Michael Shahid,Mohamed Eldeeb
Grace Hohman