Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco) [0.03%]
利用深度定量糖蛋白谱学(DQGlyco)揭示蛋白质糖基化动力学和异质性
Clément M Potel,Mira Lea Burtscher,Martin Garrido-Rodriguez et al.
Clément M Potel et al.
Protein glycosylation regulates essential cellular processes such as signaling, adhesion and cell-cell interactions; however, dysregulated glycosylation is associated with diseases such as cancer. Here we introduce deep quantitative glycopr...
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase [0.03%]
由Mnl1 / Htm1甘露糖酶和蛋白二硫异构酶双功能复合物引发的ERAD
Dan Zhao,Xudong Wu,Tom A Rapoport
Dan Zhao
Misfolded glycoproteins in the endoplasmic reticulum (ER) lumen are translocated into the cytosol and degraded by the proteasome, a conserved process called ER-associated protein degradation (ERAD). In Saccharomyces cerevisiae, the glycan o...
Evan J Worden
Evan J Worden
Author Correction: Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase [0.03%]
作者更正：复合物METTL6识别tRNA的结构基础，与SerRS丝氨酰-tRNA合成酶结合
Philipp Throll,Luciano G Dolce,Palma Rico-Lastres et al.
Philipp Throll et al.
Published Erratum
Nature structural & molecular biology. 2025 Feb 4. DOI:10.1038/s41594-025-01508-6 2025
Liu Wang,Jiahao Xie,Chong Zhang et al.
Liu Wang et al.
Circularly permuted group II introns (CP introns) consist of rearranged structural domains separated by two tethered exons, generating branched introns and circular exons via back-splicing. Structural and mechanistic understanding of circul...
A network of interacting ciliary tip proteins with opposing activities imparts slow and processive microtubule growth [0.03%]
相互作用的纤毛顶端蛋白网络赋予微管缓慢且连续增长的能力
Harriet A J Saunders,Cyntha M van den Berg,Robin A Hoogebeen et al.
Harriet A J Saunders et al.
Cilia are motile or sensory organelles present on many eukaryotic cells. Their formation and function rely on axonemal microtubules, which exhibit very slow dynamics, but the underlying mechanisms are largely unexplored. Here we reconstitut...
Cryo-EM structure of the NDH-PSI-LHCI supercomplex from Spinacia oleracea [0.03%]
菠菜NDH-PSI-LHCI超级复合物的冷冻电镜结构
Bianca Introini,Alexander Hahn,Werner Kühlbrandt
Bianca Introini
The nicotinamide adenine dinucleotide phosphate (NADPH) dehydrogenase (NDH) complex is crucial for photosynthetic cyclic electron flow and respiration, transferring electrons from ferredoxin to plastoquinone while transporting H+ across the...
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring [0.03%]
低温电镜分析补体C3揭示了巨球蛋白环可逆的主要开口现象
Trine Amalie Fogh Gadeberg,Martin Høgholm Jørgensen,Heidi Gytz Olesen et al.
Trine Amalie Fogh Gadeberg et al.
The C3 protein is the central molecule within the complement system and undergoes proteolytic activation to C3b in the presence of pathogens. Pattern-independent activation of C3 also occurs via hydrolysis, resulting in C3(H2O), but the str...
The conformational landscape of human transthyretin revealed by cryo-EM [0.03%]
冷冻电镜揭示的人类甲状腺转运蛋白构象变化景观
Benjamin Basanta,Karina Nugroho,Nicholas L Yan et al.
Benjamin Basanta et al.
Transthyretin (TTR) is a natively tetrameric thyroxine transporter in blood and cerebrospinal fluid whose misfolding and aggregation causes TTR amyloidosis. A rational drug design campaign identified the small molecule tafamidis (Vyndamax) ...
ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility [0.03%]
ELL3通过调控纺锤体组装防止母系遗传的非整倍体和不孕症
Bernhard Magerl,Tommaso Cavazza
Bernhard Magerl