Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation [0.03%]
PYROXD1介导的人tRNA连接酶复合物抵抗氧化失活的机制基础
Luuk Loeff,Alena Kroupova,Igor Asanović et al.
Luuk Loeff et al.
The metazoan tRNA ligase complex (tRNA-LC) has essential roles in tRNA biogenesis and unfolded protein response. Its catalytic subunit RTCB contains a conserved active-site cysteine that is susceptible to metal ion-induced oxidative inactiv...
Melina Casadio
Melina Casadio
Michelle Korda
Michelle Korda
Author Correction: Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants [0.03%]
《作者勘误：抗惊厥药物与突触小泡蛋白2A和2B的结合结构》
Anshumali Mittal,Matthew F Martin,Elena J Levin et al.
Anshumali Mittal et al.
Published Erratum
Nature structural & molecular biology. 2025 Mar 6. DOI:10.1038/s41594-025-01528-2 2025
Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly [0.03%]
ZFP207和U1 snRNP的凝结促进剪接体的组装
Yuenan Zhou,Chong Tong,Zuokun Shi et al.
Yuenan Zhou et al.
The U1 small nuclear ribonucleoprotein (snRNP) has an essential role in initiating spliceosome assembly, yet the mechanism underlying its synergy with other splicing regulators for efficient spliceosome assembly remains elusive. Here we ide...
Publisher Correction: Promoter-proximal RNA polymerase II termination regulates transcription during human cell type transition [0.03%]
出版更正：转录因子调控人类细胞类型转变过程中靠近启动子的RNA聚合酶II终止
Kseniia Lysakovskaia,Arjun Devadas,Björn Schwalb et al.
Kseniia Lysakovskaia et al.
Published Erratum
Nature structural & molecular biology. 2025 Mar 5. DOI:10.1038/s41594-025-01521-9 2025
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W [0.03%]
具有阿尔茨海默病构象的人MAPT突变体V337M和R406W中的tau纤维
Chao Qi,Sofia Lövestam,Alexey G Murzin et al.
Chao Qi et al.
Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are the most common forms of early-onset dementia. Unlike AD, FTD begins with behavioral changes before the development of cognitive impairment. Dominantly inherited mutations in MA...
Reconstruction of diploid higher-order human 3D genome interactions from noisy Pore-C data using Dip3D [0.03%]
利用Pore-C噪声数据重构二倍体高阶人类3D基因组相互作用的Dip3D方法
Ying Chen,Zhuo-Bin Lin,Shao-Kai Wang et al.
Ying Chen et al.
Differential high-order chromatin interactions between homologous chromosomes affect many biological processes. Traditional chromatin conformation capture genome analysis methods mainly identify two-way interactions and cannot provide compr...
CTCF-mediated 3D chromatin sets up the gene expression program in the male germline [0.03%]
由CTCF介导的3D染色体建立了雄性生殖系的基因表达程序
Yuka Kitamura,Kazuki Takahashi,So Maezawa et al.
Yuka Kitamura et al.
Spermatogenesis is a unidirectional differentiation process that generates haploid sperm, but how the gene expression program that directs this process is established is largely unknown. Here we determine the high-resolution three-dimension...