Diverse neuronal activity patterns contribute to the control of distraction in the prefrontal and parietal cortex [0.03%]
前额皮层和顶叶皮层中多样的神经元活动模式有助于分散注意力的控制
Panagiotis Sapountzis,Alexandra Antoniadou,Georgia G Gregoriou
Panagiotis Sapountzis
Goal-directed behavior requires the effective suppression of distractions to focus on the task at hand. Although experimental evidence suggests that brain areas in the prefrontal and parietal lobe contribute to the selection of task-relevan...
ParSite is a multicolor DNA labeling system that allows for simultaneous imaging of triple genomic loci in living cells [0.03%]
一种多色DNA标记系统 可以对活细胞中的三个基因组位点进行同时成像
Xiaohui He,Yadong Sun,Hanhui Ma
Xiaohui He
The organization of the human genome in space and time is critical for transcriptional regulation and cell fate determination. However, robust methods for tracking genome organization or genomic interactions over time in living cells are la...
Ventral hippocampus to nucleus accumbens shell circuit regulates approach decisions during motivational conflict [0.03%]
伏隔核壳部接受海马脑区输入并在动机冲突期间调节趋近行为决策
Dylan Patterson,Nisma Khan,Emily A Collins et al.
Dylan Patterson et al.
Successful resolution of approach-avoidance conflict (AAC) is fundamentally important for survival, and its dysregulation is a hallmark of many neuropsychiatric disorders, and yet the underlying neural circuit mechanisms are not well elucid...
Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice [0.03%]
Rspo3介导的代谢性肝脏分区调节小鼠全身葡萄糖代谢和体重
Kenji Uno,Takuya Uchino,Takashi Suzuki et al.
Kenji Uno et al.
The unique architecture of the liver consists of hepatic lobules, dividing the hepatic features of metabolism into 2 distinct zones, namely the pericentral and periportal zones, the spatial characteristics of which are broadly defined as me...
Neurofeedback and attention modulate somatosensory alpha oscillations but not pain perception [0.03%]
神经反馈和注意力调节躯体感觉α振荡但不调节疼痛感知
Vanessa D Hohn,Laura Tiemann,Felix S Bott et al.
Vanessa D Hohn et al.
Pain is closely linked to alpha oscillations (8 < 13 Hz) which are thought to represent a supra-modal, top-down mediated gating mechanism that shapes sensory processing. Consequently, alpha oscillations might also shape the cerebral process...
Cost-benefit tradeoff mediates the transition from rule-based to memory-based processing during practice [0.03%]
在练习过程中，成本效益的权衡介导了从基于规则的加工向基于记忆的加工的转变
Guochun Yang,Jiefeng Jiang
Guochun Yang
Practice not only improves task performance but also changes task execution from rule- to memory-based processing by incorporating experiences from practice. However, how and when this change occurs is unclear. We test the hypothesis that s...
Basal ganglia components have distinct computational roles in decision-making dynamics under conflict and uncertainty [0.03%]
基底神经节各组成成分在冲突和不确定情况下的决策动力学中具有不同的计算作用
Nadja R Ging-Jehli,James F Cavanagh,Minkyu Ahn et al.
Nadja R Ging-Jehli et al.
The basal ganglia (BG) play a key role in decision-making, preventing impulsive actions in some contexts while facilitating fast adaptations in others. The specific contributions of different BG structures to this nuanced behavior remain un...
DECODE enables high-throughput mapping of antibody epitopes at single amino acid resolution [0.03%]
一种以单氨基酸分辨率大规模绘制抗体表位的DECODE方法
Katsuhiko Matsumoto,Shoko Y Harada,Shota Y Yoshida et al.
Katsuhiko Matsumoto et al.
Antibodies are extensively used in biomedical research, clinical fields, and disease treatment. However, to enhance the reproducibility and reliability of antibody-based experiments, it is crucial to have a detailed understanding of the ant...
Chloramphenicol and gentamicin reduce the evolution of resistance to phage ΦX174 by suppressing a subset of E. coli LPS mutants [0.03%]
氯霉素和庆大霉素通过抑制部分大肠杆菌LPS突变体来减少ΦX174噬菌体抗性的进化
Lavisha Parab,Jordan Romeyer Dherbey,Norma Rivera et al.
Lavisha Parab et al.
Bacteriophages infect gram-negative bacteria by attaching to molecules present on the bacterial surface, often lipopolysaccharides (LPS). Modification of LPS can lead to resistance to phage infection. In addition, LPS modifications can impa...
Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion [0.03%]
增强病毒适应性和免疫逃逸的SARS-CoV-2亚基因组RNA的出现
Harriet V Mears,George R Young,Theo Sanderson et al.
Harriet V Mears et al.
Coronaviruses express their structural and accessory genes via a set of subgenomic RNAs, whose synthesis is directed by transcription regulatory sequences (TRSs) in the 5' genomic leader and upstream of each body open reading frame. In SARS...