Disrupting CD22-cis-ligand interactions ameliorates type 1 diabetes and graft rejection by expanding regulatory B cells [0.03%]
Wang Long,Ayaka Endo,Hashadi Nadeesha Walakulu Gamage et al.
Wang Long et al.
CD22 is an inhibitory receptor expressed in B cells and is constitutively associated with α2,6-sialylated membrane proteins expressed on the same cell (cis-ligands). However, interaction with cis-ligands is required for the function of CD2...
Adriana Michalak,Davide Marzoli,Francesco Pietrogiacomi et al.
Adriana Michalak et al.
Perceived sleep depth is a key determinant of subjective sleep quality, traditionally thought to reflect unconsciousness and reduced cortical activation. Here, we combined high-density EEG with a serial awakening paradigm during NREM2 (N2) ...
A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms [0.03%]
Lohany Dias Mamede,Miwei Hu,Jaime Vaquer-Alicea et al.
Lohany Dias Mamede et al.
TDP-43 pathology is a hallmark of fatal neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and limbic-predominant age-related TDP-43-encephalopathy (LATE). In affected patients, cytopl...
Jörn Diedrichsen,Samuel D McDougle
Jörn Diedrichsen
Over the past 70 years, neuroscience has gained a deep understanding of how the cerebellum supports basic motor functions. Anatomical, clinical, and neuroimaging studies, however, have also firmly established that the cerebellum holds an im...
Neha Ghosh,Eva Rojo-Iost,Jessica E Treisman
Neha Ghosh
The Drosophila corneal lens is an apical extracellular matrix structure with a biconvex shape that enables it to focus light onto the underlying photoreceptors. Here, we investigated how this shape is influenced by the source of one of its ...
Mete Yuksel,Nicole Mideo
Mete Yuksel
Can we predict which pathogen will be responsible for the next pandemic? Emergence risk is a hotly debated topic and a new study in PLOS Biology challenges the idea that pathogens that frequently spill over are more likely to emerge. ...
Brandon J Simony,David A Kennedy
Brandon J Simony
Host jumps-defined as the process by which a pathogen establishes sustained transmission in novel hosts-are threats to human and animal welfare, but anticipating which pathogen will be the next to successfully host jump remains elusive. A s...
Pharmacological and non-pharmacological methods of inducing wakefulness activate distinct neural populations in the mouse brain [0.03%]
Renato Maciel,Justin Malcey,Kylian Gautier et al.
Renato Maciel et al.
A large body of data indicate that the aminergic, cholinergic and hypocretin/orexin neurons are responsible for inducing wakefulness. However, recent data showed that other systems might also play a key role. Further, wakefulness induced by...
Distinct Cdc42 protein levels differentially regulate polarized growth and cell fusion in Schizosaccharomyces pombe [0.03%]
Sajjita Saha,Aiswarya Sajeevan,Laura Merlini et al.
Sajjita Saha et al.
The conserved Cdc42 GTPase is a key driver of symmetry breaking and polarized growth, forming zones of activity that locally recruit effectors to organize the cytoskeleton and polarize secretion. Here, we show that Cdc42 also functions in c...
Etienne Decroly,Patrick Berche,Ali Asy et al.
Etienne Decroly et al.
No matter where they are performed, studies with infectious agents need ironclad biorisk management. This can be promoted through robust gatekeeping of funding and publication, using a new formal reporting standard for pathogen research. ...