Photoinduced Trp and Tyr Side Chain Cleavage in IgG4-Fc: Impact on Physicochemical Stability and Receptor Binding and Effect of N- vs O-Glycosylation [0.03%]
光诱导IgG4-Fc中Trp和Tyr侧链断裂：对理化稳定性和受体结合的影响以及N-与O-糖基化的作用
Huan Kang,Nicholas R Larson,Yangjie Wei et al.
Huan Kang et al.
In previous studies, we discovered that the exposure of IgG4-Fc and IgG1 to UV light resulted in the side chain cleavage of specific Tyr and Trp residues, converting these amino acids into a series of products, including Gly [Haywood, J. Mo...
Acoustic Monitoring of Lubrication and Compaction Effects on Tablet Performance Using Broadband Acoustic Resonance Dissolution Spectroscopy [0.03%]
基于宽带声共振溶解谱法的润滑及压片紧实度对片剂性能影响的声学监测
Raghu V G Peddapatla,M Rizwan Ahmed,Maria J Sousa-Gallagher et al.
Raghu V G Peddapatla et al.
Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) is a novel analytical technology based on the change in the acoustic phenomena observed when a material is added into a solvent. Addition of a solid material results in the intro...
Molecular and Antiangiogenic Effects of Paclitaxel-Loaded Nanoparticles: Influence of the Nanocarrier Type [0.03%]
紫杉醇载药纳米粒的分子及抗血管生成效应：纳米载体类型的影响
Julia Sapienza Passos,Giovanna B de Melo,Giovanna C Salata et al.
Julia Sapienza Passos et al.
Nanostructured lipid carriers (NLCs) and lipid-polymeric hybrid nanoparticles (H-NPs) were developed for the local administration of paclitaxel (PTX) and breast cancer therapy. Here, we investigated how nanoparticle type and composition inf...
Gastrointestinal pH Gradient-Induced Phase Transition of Crizotinib: The Significance of pH-Dependent Ionization (Protonation) on Liquid-Liquid Phase Separation of a Weakly Basic Drug [0.03%]
胃肠道pH梯度引起的克唑替尼相变：弱碱性药物液-液相分离的pH依赖型离子化（质子化）的重要性
Ziqiao Chen,Sha Chen,Haiyan Lv et al.
Ziqiao Chen et al.
Although weakly basic drugs with specific properties (e.g., dose number >1-10, pKa 5-9) are known to form supersaturated solutions and exhibit complex phase behavior in the gastrointestinal tract, key aspects of this process (namely, the ph...
The Use of Glycine-Containing Peptide-Based Chelators for Labeling with 99mTc Improves the Imaging Properties of EpCAM-Targeting Designed Ankyrin Repeat Ec1 [0.03%]
含甘氨酸肽基螯合剂标记⁹⁹ᵐTc改善EpCAM靶向嵌合ankyrin重复蛋白成像性质
Sergey Deyev,Anastasia Fominykh,Ruslan Varvashenya et al.
Sergey Deyev et al.
Noninvasive radionuclide imaging of epithelial cell adhesion molecule (EpCAM) expression in lung, ovarian, breast, kidney, and other cancers can stratify patients for EpCAM-targeted therapy. The constructed scaffold proteins, designed ankyr...
Nebulized Inhalation of ROS-Responsive Dexamethasone-Loaded Liposomes Enhances Therapeutic Efficacy against Pulmonary Fibrosis [0.03%]
ROS响应的载地塞米松脂质体肺部雾化吸入治疗肺纤维化的研究
Jingxin Sun,Yuxin Jiao,Yong Jin et al.
Jingxin Sun et al.
This study aimed to develop and evaluate reactive oxygen species (ROS)-responsive (Thioketal-grafted DSPE-PEG2000, DTP) liposomes loaded with dexamethasone (DTP@DEX-LP) for aerosol inhalation to achieve targeted drug delivery and controlled...
Investigation of Radiolabeled KISS1R Ligands as Promising Tools for Diagnosis and Treatment of Triple-Negative Breast Cancer [0.03%]
放射标记KISS1R配体作为诊断和治疗三阴性乳腺癌的潜在工具的研究
Harun Taş,Martin Schäfer,Aneeba Shuja-Uddin et al.
Harun Taş et al.
Kisspeptins (KPs) and their receptor (KISS1R) promote metastasis and tumor progression in various cancers such as triple-negative breast cancer (TNBC). Targeting KISS1R holds great promise for molecular imaging and targeted radionuclide the...
SPECT Imaging with Bifunctional Technetium-99m Nitrido Bis(thiosemicarbazonato) Complexes Tethered to Inhibitors of the Prostate-Specific Membrane Antigen [0.03%]
用于前列腺特异性膜抗原抑制剂的双功能 technetium-99m 硝基双半碳二亚胺复合物的SPECT成像
Rachel C Maclean,Nicholas L Fletcher,Weijing Chu et al.
Rachel C Maclean et al.
We report the design and synthesis of new conjugates (H2L1-4) consisting of a bifunctional bis(thiosemicarbazone) chelator conjugated to prostate-specific membrane antigen pharmacophores. Radiolabeling H2L1-4 with the 99mTc nitrido core in ...
Enhanced Efficacy and Safety of 177Lu-Anti-CD25 Radioimmunotherapy by Combination with Targeted Anticancer Agents [0.03%]
靶向抗癌药增强放射免疫治疗疗效和安全性的研究
Jung Lim Kim,Choong Mo Kang,Kyung-Ho Jung et al.
Jung Lim Kim et al.
Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell malignancy for which improved therapeutic strategies are urgently needed. CD25, the α-chain of the interleukin-2 receptor, is abundantly expressed on malignant T cells and repre...
Experimental Evaluation and xDLVO Modeling of Excipient Effects on Protein-Protein Interactions for High-Concentration Formulations [0.03%]
高浓度蛋白质药物配方中辅料对蛋白相互作用的实验研究及xDLVO机理模型分析
Kai Ge,Jiabin Shen,Yuanhui Ji
Kai Ge
The rational design of high-concentration protein formulations remains a significant challenge in biopharmaceutical development, which requires the screening of effective excipients to suppress aggregation. This study presents a combined ex...