Gastrointestinal pH Gradient-Induced Phase Transition of Crizotinib: The Significance of pH-Dependent Ionization (Protonation) on Liquid-Liquid Phase Separation of a Weakly Basic Drug
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Although weakly basic drugs with specific properties (e.g., dose number >1-10, pKa 5-9) are known to form supersaturated solutions and exhibit complex phase behavior in the gastrointestinal tract, key aspects of this process (namely, the physical stability of ... ...
