Attenuated Toxicity and Antitoxic Mechanism via Sodium Iodide Symporter Inhibition-Based Tumor-Selective Delivery in Astatine-211 Radioimmunotherapy [0.03%]
基于钠碘转运体抑制的肿瘤选择性传递 attenuated toxicity和抗毒性机制在砹-211放射免疫治疗中的作用
Hiroki Takashima,Ryo Tsumura,Yoshikatsu Koga et al.
Hiroki Takashima et al.
Astatine-211 (211At) is a promising alpha emitter for cancer treatment, wherein tumor-selective accumulation is pivotal due to its short path length. While sodium ascorbate (SA) successfully protects radioactive antibodies from reactive oxy...
A Doppler/Near-Infrared-Mediated Visual Real-Time Positioning Microbubble-Based Drug Delivery System Integrating Chemotherapy, Photodynamic Therapy, and Photothermal Therapy for the Treatment of Superficial Tumors [0.03%]
一种多普勒/近红外介导的可视化实时定位微泡递药系统用于肿瘤的化疗、光动力治疗及光热治疗
Zhiqiang Zhang,Chenxi Fang,Yingjie Ma et al.
Zhiqiang Zhang et al.
The treatment of superficial tumors is often limited by poor drug targeting and a lack of real-time visualization of drug distribution. To address these challenges, we developed an RGD-modified microbubble system (TF/ICG-MB@RGD) for ultraso...
Eutectic Coamorphous System of Enzalutamide and Acetyl Maltose: A Strategy for Improved Physical Stability and Aqueous Solubility [0.03%]
恩扎卢胺与乙酰麦芽糖共晶体系的研究：一种改善物理稳定性和水溶性的策略
Julia Cichocka-Łokuciejewska,Justyna Knapik-Kowalczuk,Mateusz Dulski et al.
Julia Cichocka-Łokuciejewska et al.
The low aqueous solubility of crystalline enzalutamide (ENZ) and the limited physical stability of amorphous ENZ present significant formulation challenges. In this study, we explore binary co-amorphous systems of ENZ with octaacetyl maltos...
Curcumin-Loaded Liposomes (hPLipo/Cur) with Liver-Targeting Properties for Efficient NAFLD Treatment by Alleviating Mitochondrial ROS-Mediated Ferroptosis via NRF2 Pathway [0.03%]
一种具有肝靶向性的姜黄素载脂体制剂(hPLipo/Cur)，通过NRF2途径缓解线粒体ROS介导的铁死亡，有效治疗NAFLD
Xue Wang,Rui Fang,Tianming Zhao et al.
Xue Wang et al.
NAFLD is a rising health problem worldwide with unsatisfied therapies. Curcumin has an ameliorative but limited effect on NAFLD due to its low water solubility. In this study, we innovatively establish the high-PC-content liposome-loaded cu...
Hypoxia-Responsive Retinoid Liposomes for Tumor Microenvironment-Activated Differentiation and Metastasis Suppression [0.03%]
缺氧响应型视黄醇脂质体用于肿瘤微环境激活的分化及转移抑制作用
Chunlin Li,Di Liu,Xiaojie Li et al.
Chunlin Li et al.
Cancer stem-like cells (CSCs) are a key driving factor of tumor heterogeneity, metastasis, and chemoresistance. All-trans retinoic acid (ATRA) shows strong potential for inducing CSC differentiation and reducing stemness; however, its clini...
Curcumin-Fullerene Nanoantioxidant Treats Ulcerative Colitis through Antioxidant and Anti-Inflammatory Mechanisms [0.03%]
姜黄素富勒烯纳米抗氧化剂通过抗氧化和抗炎机制治疗溃疡性结肠炎
Yuanyuan Liu,Mingzhe Li,Shikui Wu et al.
Yuanyuan Liu et al.
Active compounds derived from traditional Chinese medicine have attracted considerable interest as potential strategies for alleviating inflammation. However, their clinical translation is often impeded by limitations, including poor bioava...
An Expert's View on the Application of TIM Technology in the Development of Oral Drug Products [0.03%]
专家视角：TIM技术在口服药物产品开发中的应用
Álvaro López Mármol,Richard Barker,Mirko Koziolek et al.
Álvaro López Mármol et al.
The TIM models tiny-TIM and TIM-1 enable a physiologically relevant in vitro simulation of drug product performance in the upper human gastrointestinal tract under various intake conditions. These systems are considered to be among the most...
Thermal Stability of IgG4 Monoclonal Antibodies: Ambiguous Roles of Cosolutes, Excipients, and Salts in Conformational and Colloidal States [0.03%]
IgG4单克隆抗体的热稳定性：助溶剂，辅料和盐在构象和胶体状态中的作用含糊其辞
Ji-Young Yang,Oliver Burkert,Boris Mizaikoff et al.
Ji-Young Yang et al.
Peptide and antibody therapeutics are increasingly central to modern drug development, yet their formulation remains challenged by intrinsic instabilities and aggregation tendencies. In this work, we study the thermal stability of an IgG4 m...
A Smart Dicyano-Based Fluorescent Probe for In Vivo Amyloid-β Visualization to Illuminate Alzheimer's Disease [0.03%]
一种用于阿尔茨海默病脑内活体成像的智能茋基氰酰胺荧光探针
Xiao Li,Haijun Yang,Zeying Liang et al.
Xiao Li et al.
Amyloid-β (Aβ) is a key biomarker for Alzheimer's disease (AD), with its abnormal aggregation closely linked to AD pathology. Fluorescence imaging shows promise for Aβ detection but faces challenges such as optical instability, a short b...
Evaluation of RBC Targeting As a Strategy to Extend Half-Life and Reduce Nonspecific Tissue Uptake of Biologics [0.03%]
评估针对RBC的目标策略以延长生物制品的半衰期和减少非特异性组织摄取
Nicholas Cho,Hanine Rafidi,Travis Morgenstern et al.
Nicholas Cho et al.
Delivery strategies exploiting red blood cells (RBCs) have been widely pursued, particularly for the purpose of achieving sustained systemic exposure to small molecule drugs. However, limited efforts have been focused on applying RBC-inspir...