Repeated simulated ischemia and protection against gap junctional uncoupling [0.03%]
反复模拟缺血对缝隙连接脱耦的保护作用
R Sundset,K Ytrehus,Y Zhang et al.
R Sundset et al.
Ischemic preconditioning increases the heart's tolerance to a subsequent longer ischemic period. The aim of this study was to investigate the effect of early and delayed preconditioning on gap junction communication, connexin abundance, and...
The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response [0.03%]
鼠类CD99相关分子CD99样分子2(CD99L2)是一种参与炎症反应的粘附分子
Alan R Schenkel,Eric M Dufour,Tina W Chew et al.
Alan R Schenkel et al.
CD99, a glycoprotein found on the surfaces of leukocytes and concentrated at the borders of endothelial cells, plays a major role in the migration of leukocytes across endothelial cells into sites of inflammation, and has other roles in thy...
Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3 [0.03%]
AKT在丝裂原活化蛋白激酶的作用下将Connexin43磷酸化为Ser373，它是14-3-3“模式1”结合位点
Darren J Park,Christopher J Wallick,Kendra D Martyn et al.
Darren J Park et al.
Connexin43 (Cx43) is a membrane-spanning protein that forms channels that bridge the gap between adjacent cells and this allows for the intercellular exchange of information. Cx43 is regulated by phosphorylation and by interacting proteins....
Early response of endothelial cells to flow is mediated by VE-cadherin [0.03%]
血管内皮细胞早期流动反应由血管钙粘蛋白介导
Aleksandr Rabodzey,Yu Yao,Francis W Luscinskas et al.
Aleksandr Rabodzey et al.
Endothelial cells are known to respond to flow onset by increasing actin turnover rate. Current models assume that an increase in the actin turnover rate should result in a rise in cell crawling speed. Here we report that confluent endothel...
Influence of systematically varied nano-scale topography on cell morphology and adhesion [0.03%]
系统性纳米拓扑结构变化对细胞形态和粘附的影响研究
Sepideh Heydarkhan-Hagvall,Chang-Hwan Choi,James Dunn et al.
Sepideh Heydarkhan-Hagvall et al.
The types of cell-matrix adhesions and the signals they transduce strongly affect the cell-phenotype. We hypothesized that cells sense and respond to the three-dimensionality of their environment, which could be modulated by nano-structures...
A novel subcellular collagen organization process visualized by total internal reflection fluorescence microscopy [0.03%]
利用全内反射荧光显微镜观察的新型亚细胞胶原组织过程
Erik F Young,Eugene E Marcantonio
Erik F Young
The alpha1beta1 and alpha2beta1 integrins belong to a family of cell-surface molecules involved in structural contacts and signal-transduction events across the cell membrane. Employing two-dimensional substrates coated with fluorescently l...
Double-layered collagen gel hemisphere for cell invasion assay: successful visualization and quantification of cell invasion activity [0.03%]
双层胶原凝胶半球体细胞侵袭检测试剂盒成功地实现了对细胞侵袭活性的可视化与量化分析
Masahiko Takata,Yoshimasa Maniwa,Takefumi Doi et al.
Masahiko Takata et al.
Although various methods for collagen gel-based cell invasion assays have been described, there continues to be a need for a simpler and more objective assay. Here, we describe an easy-to-prepare double-layered collagen gel hemisphere (DL-C...
Urokinase receptor (CD87) clustering in detergent-insoluble adhesion patches leads to cell adhesion independently of integrins [0.03%]
尿激酶受体（CD87）在洗涤剂不易溶解的粘附斑中的聚集独立于整合素导致细胞黏附
Jutta Petzinger,Frederic Saltel,Karin Hersemeyer et al.
Jutta Petzinger et al.
The urokinase-type plasminogen activator receptor (uPAR) is a glycosylphosphatidyl inositol-anchored protein that mediates cell adhesion to the extracellular matrix protein vitronectin (VN). We demonstrate here that this cell adhesion proce...
Impaired gap junction formation and intercellular calcium signaling in urinary bladder cancer cells can be improved by Gö6976 [0.03%]
Gö6976可改善膀胱癌细胞连接间隙形成及细胞间Ca2+信号转导异常
Pekka Leinonen,Vesa Aaltonen,Sanna Koskela et al.
Pekka Leinonen et al.
Purpose: Calcium wave propagation and connexin 26, 32 and 43 expression were studied in normal and malignant urothelial cells. Materials and methods: ...
Ischemia-induced cleavage of cadherins in NRK cells is not sufficient for beta-catenin transcriptional activity [0.03%]
NRK细胞中的缺血诱导型粘附素裂解不足以引起β-链蛋白的转录活动
Gang Chen,Adebayo D Akintola,Jeffrey M Catania et al.
Gang Chen et al.
Although ischemia is associated with disruption of cadherin-mediated adhesion in renal cell lines, the impact of decreased cadherin function on the transcriptional activity of beta-catenin remains poorly defined. In these studies, we used a...