SpeckSeq enables high-throughput functional stratification of MEFV variants in autoinflammatory diseases [0.03%]
SpeckSeq使MEFV变异在自身炎症性疾病中的功能分层成为可能
Pauline Bronnec,Sarah Dalmon,Chloe Briand et al.
Pauline Bronnec et al.
Variants of uncertain significance (VUS) are a major obstacle in genetic diagnosis, particularly when involving gain-of-function (GoF) mutations that are poorly predicted in silico. MEFV, which encodes the inflammasome sensor pyrin, is muta...
XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance [0.03%]
XPR1调节胎儿肝巨噬细胞的发育、身份和处理皮红细胞的能力
Sebastian A Stifter,Mitchell Bijnen,Selma Tuzlak et al.
Sebastian A Stifter et al.
Inorganic phosphate (Pi) is an essential nutrient for all organisms. It has critical functions in lipid and nucleic acid synthesis, protein signaling and bone growth. Loss-of-function mutations in Pi transporters lead to embryonic and neona...
Amyloidosis of bridging veins is a pathologic feature of Alzheimer's disease [0.03%]
淀粉样蛋白血脑桥静脉病是阿尔茨海默病的病理特征
Leon C D Smyth,Daan Verhaege,Elio Standen-Bloom et al.
Leon C D Smyth et al.
Alzheimer's disease (AD) is characterized by the accumulation of extracellular aggregated amyloid beta, resulting from impaired waste clearance. We recently identified new cerebrospinal fluid (CSF) efflux structures termed arachnoid cuff ex...
A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes [0.03%]
小鼠淋巴结成纤维网状细胞和血管平滑肌细胞由共同的前体细胞分化产生
Lisa Kurz,Mechthild Lütge,Angelina De Martin et al.
Lisa Kurz et al.
The interaction of immune cells in the lymph node microenvironment depends on the infrastructure and molecular cues provided by fibroblastic reticular cells (FRCs). In addition, concentric layers of still poorly defined mural cells, includi...
The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites [0.03%]
抗原呈递分子MR1结合宿主产生的核黄素分解产物
Mohamed R Abdelaal,Jieru Deng,Mitchell P McInerney et al.
Mohamed R Abdelaal et al.
MHC class I-related protein (MR1) presents vitamin B-based antigens (Ags) to mucosal-associated invariant T (MAIT) cells. While microbial riboflavin (RF) precursors are well-documented MR1 ligands, it is unclear whether host-generated RF ca...
Correction: Neonatal microbiota colonization primes maturation of goblet cell-mediated protection in the pre-weaning colon [0.03%]
纠正： neonatal 微生物组定植促使肠道杯状细胞介导的保护作用在断奶前成熟
Åsa Johansson,Mahadevan Venkita Subramani,Bahtiyar Yilmaz et al.
Åsa Johansson et al.
pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection [0.03%]
感染再燃时，pDCs可放大组织驻留记忆CD8+t细胞的免疫反应
Elena Hernández-García,Miguel Galán,Sofía C Khouili et al.
Elena Hernández-García et al.
Resident memory CD8+ T cells (Trms) are essential for protecting barrier nonlymphoid tissues (NLTs) against reinfection, yet the involvement of dendritic cells (DCs) in this process and the nature of Trm-DC interactions within these tissues...
Mattison P Stojcic,Pariya Yousefi,Catherine M Biggs et al.
Mattison P Stojcic et al.
Interferon regulatory factors (IRFs) are a family of transcription factors essential for immune system development and host defense. Beyond immunity, IRF6 plays an indispensable role in craniofacial development. Inborn errors of IRFs (IE-IR...
SLC7A8 is essential for metabolic fitness and function of Th2 cells [0.03%]
SLC7A8对Th2细胞代谢适应性和功能的必要性
Santosh K Panda,Do-Hyun Kim,Pritesh Desai et al.
Santosh K Panda et al.
Amino acids are essential for the activation and function of CD4 T helper (Th) cells, which differentiate into Th1, Th2, Th17, and Treg subsets to coordinate immune responses. While specific amino acid transporters have been identified for ...
Victor Bosteels,William Stainier,Caetano Reis E Sousa
Victor Bosteels
Apoptotic cell (AC) corpses can be taken up by certain types of dendritic cell (DC), which cross-present dead cell-derived antigens. In this issue of JEM, Tam et al. (https://doi.org/10.1084/jem.20250887) reveal that GPR34, a lysophosphatid...