Sensory cilia: How molecular motors can shape ciliary tip organization and diversity [0.03%]
感觉纤毛：分子马达如何可以塑造纤毛末端的组织和多样性
Bénédicte Durand
Bénédicte Durand
In this issue, Wang et al. (https://doi.org/10.1083/jcb.202412213) reveal the specific contribution of the Kif19A kinesin motor to the shaping of the ciliary endings of Drosophila mechanosensory organs. They also explain, using mathematical...
Layla M Nassar,Shawn M Ferguson
Layla M Nassar
Several mechanisms repair damaged lysosomal membranes, but how can lysosomes prevent membrane failure in the first place? Kim et al. (https://doi.org/10.1083/jcb.202509180) uncover a rapid response whereby TMEM63A-dependent ion efflux relie...
Polyploidy reprograms epithelial cells for motility and phagocytosis via stress signaling [0.03%]
多倍体通过压力信号重编程上皮细胞迁移和吞噬功能
Youfang Zhou,Xianfeng Wang,Xiaochao Tan et al.
Youfang Zhou et al.
Polyploidy, an increase in cellular genome content, is a conserved developmental program and a hallmark of malignant cancer, yet its impact on cell behavior remains poorly understood. Here, we show that induction of polyploidy in otherwise ...
COPI-dependent intra-Golgi recycling at an intermediate stage of cisternal maturation [0.03%]
大分子转移过程中高尔基体中间层囊腔的依赖于COPI的回收机制
Adam H Krahn,Areti Pantazopoulou,Jotham Austin nd et al.
Adam H Krahn et al.
The traffic pathways that recycle resident Golgi proteins during cisternal maturation are not completely defined. We addressed this challenge using the yeast Saccharomyces cerevisiae, in which maturation of individual cisternae can be visua...
HSF2-HSP110 axis supports genome stability via RNA polymerase II transcription and DNA repair [0.03%]
HSF2-HSP110轴通过RNA聚合酶II转录和DNA修复支持基因组稳定性
Xiongjie Jin,Caixia Xi,Bhaumik Pandya et al.
Xiongjie Jin et al.
The precise regulation of RNA polymerase II (RNAPII) is essential for transcriptional fidelity and genome stability. Here, we identify a previously unrecognized genotoxic stress-responsive transcriptional axis composed of heat shock factor ...
Bistable Otx2-Id1 circuitry governs a developmental transition state in the pluripotency continuum [0.03%]
双稳Otx2-Id1线路调控多能性连续谱系中的发育过渡态
Peng Chen,Zhenhua Zhu,Baoxing Dong et al.
Peng Chen et al.
While current pluripotency models capture discrete embryonic stages, they inadequately resolve transitional states during peri-implantation development. Here, we establish rosette-formative intermediate stem cells (rfISCs) from mouse embryo...
Shuonan Wang,Weisi Wang,Jiamei Qiao et al.
Shuonan Wang et al.
Migrasomes are key organelles in cell-cell communication, playing a role in embryonic morphogenesis, angiogenesis, coagulation, and mitochondrial homeostasis. Migrasome formation involves the assembly of tetraspanin-enriched microdomains (T...
Non-telomeric TRF2 regulates differentiation-associated genes to maintain neural stem cell identity [0.03%]
TRF2通过调节与分化相关的基因来维持神经干细胞的同一性
Soujanya Vinayagamurthy,Amit Kumar Bhatt,Sulochana Bagri et al.
Soujanya Vinayagamurthy et al.
Depletion of TRF2 from chromosome ends causes telomeric fusions and genome instability in mammals, but in mouse neural stem cells (mNSCs), Trf2's role is non-telomeric. Although essential for mNSC proliferation and survival, Trf2 does not p...
ER-derived caveolin-coated vesicles transport newly synthesized cholesterol to the plasma membrane [0.03%]
由新生胆固醇组成的ER衍生的caveolin包裹小体将其运输到细胞膜
Ming Sun,Yuan-Bin Liu,Pu-Yu Sun et al.
Ming Sun et al.
Cholesterol must be precisely partitioned within cells, with the plasma membrane (PM) holding the highest levels. In contrast, the endoplasmic reticulum (ER)-the site of cholesterol synthesis-contains very little cholesterol. How newly synt...
Assembly and phosphoregulatory mechanisms of the budding yeast outer kinetochore KMN complex [0.03%]
酿酒酵母外层着丝粒颗粒(KMN)复合体的装配及其磷酸调控机制
Noah N Turner,Ziguo Zhang,Jing Yang et al.
Noah N Turner et al.
During mitosis and meiosis, kinetochores mediate interactions between chromosomes and spindle microtubules. Kinetochores are multi-megadalton protein complexes essential for chromosome segregation; however, recent structural, functional, an...