Independent nuclear and organellar mechanisms determine apicoplast fate in malaria parasites [0.03%]
疟原虫中独立的核和器官ellar机制决定内质网的命运
Michal Shahar,Alia Qasem,Eshkar Shamay et al.
Michal Shahar et al.
The apicoplast organelle of the malaria parasite, Plasmodium falciparum, is essential for parasite replication, though its cell cycle regulation remains poorly understood. We developed a dynamic live-imaging platform with analytical capabil...
TMEDs mediate versatile cargo transport in vesicle-dependent unconventional secretion [0.03%]
TMED蛋白介导依赖囊泡的非经典分泌途径中的多种货物运输
Jianfei Zheng,Haodong Wang,Yuxin Sun et al.
Jianfei Zheng et al.
Unconventional protein secretion (UcPS) exports diverse signal peptide-lacking cargoes, yet its cargo selectivity remains poorly understood. Here, we identify TMED proteins as key regulators of vesicle-dependent UcPS, mediating selective ca...
Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles [0.03%]
ErbB3丢失将整合素β1从早期胞内囊泡循环转运重新定向到胞外囊泡分泌中
Dorival Mendes Rodrigues-Junior,Ana Rosa Sáez-Ibáñez,Takeshi Terabayashi et al.
Dorival Mendes Rodrigues-Junior et al.
Receptor tyrosine kinases (RTKs) are important cargo in endocytic trafficking, yet their role in endosomal sorting and maturation of multivesicular bodies remains unclear. Here, we show that the ErbB3 (HER3) receptor sorts internalized Inte...
lncRNA EGFR-AS1 promotes DNA damage repair by enhancing PARP1-mediated PARylation [0.03%]
长链非编码RNA EGFR-AS1通过增强PARP1介导的PARylation促进DNA损伤修复
Kun Gao,Ruiya Shi,Chenying Xu et al.
Kun Gao et al.
DNA damage repair is vital for maintaining genetic stability and integrity of cells that encounter DNA-damaging agents. So far, a series of multifunctional proteins and long noncoding RNAs (lncRNAs) have been demonstrated to participate in ...
High-resolution mapping of the actin fusion focus reveals myosin V-dependent formin transport for aster formation [0.03%]
高分辨率的肌动蛋白融合焦点图谱揭示了肌球蛋白V依赖的鸟苷酸结合蛋白同系物Formin运输以形成星状体
Valentine Thomas,Hikari Mase,Laetitia Michon et al.
Valentine Thomas et al.
Many processes such as polarized growth and secretion require specific actin networks. In fungi, cell-cell fusion requires cell wall digestion mediated by local secretion of lytic enzymes. In Schizosaccharomyces pombe, the myosin V Myo52 tr...
DUX4-induced HSATII RNA accumulation drives protein aggregation, impacting RNA processing pathways [0.03%]
DUX4诱导的HSATII RNA累积导致蛋白质聚集并影响RNA加工途径
Tessa Arends,Sean R Bennett,Stephen J Tapscott
Tessa Arends
RNA-driven protein aggregation leads to cellular dysregulation and contributes to the development of diseases and tumorigenesis. Here, we show that double homeobox 4 (DUX4), an early embryonic transcription factor and causative gene of faci...
Phosphatidylserine exposure and annexin A5 weaken the actin cortex in osteoclast fusion [0.03%]
磷脂酰丝氨酸暴露和 Annexin A5 削弱破骨细胞融合中的肌动蛋白皮层
Evgenia Leikina,Andrey K Tsaturyan,Kamran Melikov et al.
Evgenia Leikina et al.
Diverse cell-cell fusions involve Ca2+ signaling, exposure of phosphatidylserine (PS) at the cell surface and binding of extracellular annexin A5 (Anx A5). Here we report that in the fusion stage of osteoclast formation, each of these share...
Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway [0.03%]
细胞动力学通过生物发生途径快速整联蛋白运输调节
Martina Lerche,Mathilde Mathieu,Hellyeh Hamidi et al.
Martina Lerche et al.
Constitutive integrin endocytosis and recycling control cell movement and morphology. In contrast, the role of newly synthesized integrins delivered via the biosynthetic pathway has been largely overlooked. We used the retention using selec...
GARLH regulates neuroligin preference for excitatory versus inhibitory synapses [0.03%]
GARLH调节神经黏附分子 Neuroligin 形成兴奋性或抑制性突触的选择性
Tokiwa Yamasaki,Kohtarou Konno,Dilja Krueger-Burg et al.
Tokiwa Yamasaki et al.
Synaptic specificity is governed by precise combinations of cell adhesion proteins that stabilize pre- and postsynaptic sites and appropriate neurotransmitter receptors. The postsynaptic neuroligins NL1/3 and NL2/3/4 localize to excitatory ...
Is the Parkinson's-associated protein TMEM175 a proton channel: Yay or nay? [0.03%]
TMEM175是与帕金森病相关的蛋白质：它是质子通道吗？
Spencer A Freeman,Sergio Grinstein
Spencer A Freeman
The abnormal protein degradation implicated in the pathogenesis of Parkinson's disease was previously attributed to defective H+ leakage from lysosomes via TMEM175 (https://doi.org/10.1016/j.cell.2022.05.021). In this issue, Riederer et al....