The Rab GEF VINE couples phosphatase recruitment to GAP-mediated Rab5 inactivation [0.03%]
VINE通过GAP介导的Rab5失活招募磷酸酶
Mia S Frier,Shawn P Shortill,Michael Davey et al.
Mia S Frier et al.
Rab5-family GTPases cycle between active and inactive forms to regulate endosomal membrane identity and protein trafficking. VPS9-family guanine nucleotide exchange factors (GEFs) promote Rab activation at endosomes, whereas GTPase-activati...
Intercellular mitochondrial transfer and trans-mitophagy in response to protein import dysfunction [0.03%]
蛋白质输入功能障碍下的细胞间线粒体转移和跨细胞自噬作用
Emily Glover,Beth Wiseman,Celyn Dugdale et al.
Emily Glover et al.
Mitochondrial protein import is critical for organelle biogenesis, maintenance, and regeneration-essential for cellular homeostasis. Import dysfunction compromises cellular energy supplies, which is damaging to cells, particularly those wit...
aPKC exclusion from the apical cortex in enteroblasts maintains stem cell homeostasis in Drosophila [0.03%]
果蝇肠干细胞稳态维持中的aPKC顶区排挤效应
Yasushi Izumi,Mikio Furuse
Yasushi Izumi
Proper control of stem cell behavior is crucial for maintaining tissue homeostasis. In the Drosophila midgut, smooth septate junction (sSJ)-associated proteins play a crucial role in regulating intestinal stem cell (ISC) proliferation via a...
A pan-vertebrate signaling motif controls the molecular function of intracellular AQP12 [0.03%]
一种泛脊椎动物信号基序控制着胞内AQP12的分子功能
François Chauvigné,Marc Catalán-García,Xavier Daura et al.
François Chauvigné et al.
Unorthodox AQP12-type channels are poorly understood intracellular aquaporins localized in the endoplasmic reticulum and zymogen granules (ZGs) of pancreatic acinar cells. Despite connections to major diseases, their biophysical properties ...
Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin [0.03%]
束状F肌动蛋白复合物的协同装配、解离及保护机制研究
Sudeepa Rajan,Jimok Yoon,Heng Wu et al.
Sudeepa Rajan et al.
Actin's transition from monomers (G-actin) to polymers (F-actin) and then into bundled and branched networks underlies many cellular and system functions. Yet, how these networks are dynamically assembled and disassembled is incompletely un...
Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1 [0.03%]
紫外线损伤修复中XPG蛋白的招募与释放受预切和后切因子及EXO1调控
Alba Muniesa-Vargas,Cristina Ribeiro-Silva,Carlota Davó-Martínez et al.
Alba Muniesa-Vargas et al.
The XPG endonuclease is crucial for nucleotide excision repair (NER) and other genome maintenance pathways. Precise regulation of XPG recruitment and activity during DNA repair is essential to avoid erroneous DNA incisions and genomic insta...
Meiotic CENP-C supports centromere assembly and kinetochore recruitment in spermatogenesis [0.03%]
减数分裂CENP-C在精子发生过程中支持着丝粒装配和动粒蛋白募集
Rachel S Keegan,Dina Malkeyeva,Meg B Weever et al.
Rachel S Keegan et al.
The centromere is the chromosomal site of kinetochore assembly, defined by the histone H3 variant CENP-A. In each cell cycle, the assembly and maintenance of CENP-A is functionally critical for chromosome segregation. In Drosophila male mei...
Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity [0.03%]
磷脂酰丝氨酸和RhoB连接PI4P和PA代谢以维持质膜身份
Shiying Huang,Yeun Ju Kim,Xiaofu Cao et al.
Shiying Huang et al.
Proper functions of cellular organelles require tight control of membrane phospholipid composition, yet the mechanisms by which lipid imbalances are sensed and corrected remain largely unknown. Here, we present evidence of an unexpected met...
PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum [0.03%]
PIKfyve影响内质网和溶酶体之间的互作以调节内质网动力学
Nicala Jenkins,Zainab Adamji,Maria R Narciso et al.
Nicala Jenkins et al.
Lysosomes clear unwanted cellular material delivered by constant membrane fusion. Membrane fission is thus required to balance lysosome size, number, and composition. PIKfyve is a lipid kinase that converts phosphatidylinositol-3-phosphate ...
Sequential changes in calcium transients during M phase regulate cardiomyocyte proliferation [0.03%]
M期的钙瞬变的连续变化调节心肌细胞增殖
Honghai Liu,Niyatie Ammanamanchi,Jocelyn D Mich-Basso et al.
Honghai Liu et al.
Heart muscle growth and regeneration require the proliferation of cardiomyocytes. Rapid pulsatile increases in cytosolic Ca2+ concentration, called calcium transients (CaTs), trigger cardiomyocyte contractions, but how cardiomyocytes adapt ...