Seohyun Park,Fiona Fitzgerald,Yoon-Mo Yang et al.
Seohyun Park et al.
Ribosome specialization, whereby ribosomes of distinct composition translate different sets of mRNAs, is a concept that has garnered both wide-spread excitement and skepticism from the translation field. The controversy is rooted in experim...
Neutrophil serine proteases degrade endothelial cortactin and promote extravasation [0.03%]
中性粒细胞丝氨酸蛋白酶降解内皮细胞皮层 actin 结合蛋白 cortactin 并促进细胞外渗
Idaira M Guerrero-Fonseca,Karina B Hernández-Almaraz,Iliana I León-Vega et al.
Idaira M Guerrero-Fonseca et al.
The adhesive interactions of neutrophils with postcapillary venules during inflammation have been well studied. However, how neutrophils trigger molecular changes in endothelial cells (EC) during their extravasation requires further explora...
Eosinophils promote a second wave of postnatal smooth muscle differentiation in intestinal villi [0.03%]
嗜酸性粒细胞促进肠道绒毛在出生后平滑肌分化第二波的发展
Tatiana V Petrova,Kelly de Korodi,Thea Berg et al.
Tatiana V Petrova et al.
Intestinal villus smooth muscle cells (SMCs) play a critical structural and functional role in the gut, notably facilitating dietary fat transport via villus-associated lymphatic lacteals. In the early postnatal period, subepithelial PDGFR...
Mitochondrially tethered Mmm1 can function as a sole lipid transporter at ER-mitochondria contacts [0.03%]
线粒体锚定的Mmm1可以在线粒体-内质网接触点上作为唯一的脂质转运蛋白发挥作用
Christian Covill-Cooke,Takashi Hirashima,Shin Kawano et al.
Christian Covill-Cooke et al.
Yeast mitochondria receive the majority of their lipids from the ER via the heterotetrameric ERMES lipid transport complex. This complex is thought to establish a lipid-transporting bridge of fixed composition spanning the space between bot...
Disruption of macrophage cell volume drives inflammatory responses and type I interferon signaling [0.03%]
巨噬细胞细胞体积紊乱驱动炎症反应和I型干扰素信号转导
James R Cook,Tara A Gleeson,Sara Gago et al.
James R Cook et al.
Macrophages coordinate inflammatory and immune responses to threats, yet how they interpret diverse danger signals to tailor inflammation remains unclear. Disturbances in extracellular and intracellular homeostasis alter cell volume, but th...
NASP functions in the cytoplasm to prevent histone H3 aggregation during early embryogenesis [0.03%]
鼻尖素在细胞质中防止胚胎发育早期组蛋白H3聚集
Mohit Das,Eli Coronado-Chavez,Anusha D Bhatt et al.
Mohit Das et al.
From their molecular birth until their incorporation into chromatin, histones are bound by specific chaperones that serve unique functions in histone trafficking, stability, and chromatin deposition. The H3-specific chaperone NASP binds dir...
Bitesize bundles F-actin and influences actin remodeling in syncytial Drosophila embryo development [0.03%]
Bitesize通过F-肌动蛋白重塑调控果蝇同步胚的发育
Anna R Yeh,Gregory J Hoeprich,Anthony D McDougal et al.
Anna R Yeh et al.
Actin networks undergo rearrangements that influence cell shape. Actin network organization is regulated by a host of actin-binding proteins. The Drosophila synaptotagmin-like protein, bitesize (Btsz), organizes actin at epithelial cell api...
Ravikanth Appalabhotla,Priscila F Siesser,Harrison Truscott et al.
Ravikanth Appalabhotla et al.
Phospholipase C-γ1 (PLC-γ1) signaling is required for mesenchymal chemotaxis, but is it sufficient to bias motility? PLC-γ1 enzyme activity is basally autoinhibited, and light-controlled membrane recruitment of wild-type PLC-γ1 (OptoPLC...
Phosphatidylserine is a component of the gradient-tracking machine in mating yeast [0.03%]
磷脂酰丝氨酸是交配酵母梯度追踪机器的组成部分
Chih-Yu Pai,Xin Wang,Hamida Mahmood et al.
Chih-Yu Pai et al.
Chemotropism, the ability to orient growth toward external chemical cues, is a fundamental process in diverse eukaryotic systems. During mating, budding yeast cells detect pheromone gradients from potential partners, locating them by assemb...
LGL-1 and the RhoGAP protein PAC-1 redundantly polarize the Caenorhabditis elegans embryonic epidermis [0.03%]
LGL-1和RhoGAP蛋白PAC-1通过冗余方式对秀丽杆线虫胚胎表皮进行极化
Olga D Jarosińska,Amalia Riga,Hala Zahreddine Fahs et al.
Olga D Jarosińska et al.
Apical-basal polarity is essential for epithelial organization and function and is established by conserved cortical polarity proteins. However, the requirements for canonical polarity factors vary between tissues and organisms. For example...