Strength in numbers: Proteins travel as condensates to reinforce cell-cell junctions under stress [0.03%]
万众一心：蛋白质凝聚物在压力下传输以强化细胞间连接
Jiarui Jiang,Katheryn E Rothenberg
Jiarui Jiang
Cell-cell junctions under stress recruit proteins to reinforce adhesion, but how these proteins are rapidly delivered is unclear. In this issue, Zheng et al. (https://doi.org/10.1083/jcb.202601182) identify a mechanism whereby the adhesion ...
Arl8b inactivates the Rab11a recycling pathway to promote LAMP1 sorting and lysosome biogenesis [0.03%]
Arl8b通过使Rab11a回圈途径失活促进LAMP1分类和溶酶体生物合成
Priya Chouhan,Yogita Phogat,Kshitiz Walia et al.
Priya Chouhan et al.
The small GTP-binding protein Arl8b is established as a regulator of lysosome positioning and fusion, yet its role in lysosome biogenesis remains unclear. Here, we investigate the role of Arl8b in the trafficking of newly synthesized LAMP1 ...
Judith Zubia-Aranburu,Lingxiao Zhang,Mingdong Dong
Judith Zubia-Aranburu
T cells are central to adaptive immunity, and continuously sense, generate, and respond to mechanical forces. Advances in mechanoimmunology show that T-cell behavior is tightly shaped by the physical properties of their environment, includi...
Ana1/CEP295 regulates centriolar doublet-to-triplet conversion during spermatogenesis [0.03%]
Ana1/CEP295在精子发生过程中调控中心粒双联微管向三联微管的转换
Zhou Chen,Dongqing Li,Nan Pang et al.
Zhou Chen et al.
The centriole is well recognized for its ninefold symmetry, with nine microtubule blades arranged in a barrel-like structure. However, these blades adopt diverse architectures across evolution, ranging from microtubule singlets to triplets,...
Hannah L Coveney,Yuxin Hong,Priya Crosby
Hannah L Coveney
In this issue, Wang et al. (https://doi.org/10.1083/jcb.202509044) report that in the syncytial fungus Neurospora crassa, the core proteins regulating circadian rhythms are shared between adjacent nuclei. They also show that core circadian ...
Core clock protein subcellular dynamics coordinate local and global circadian control in syncytia [0.03%]
核心时钟蛋白的亚细胞动态在-syncytia中协调局部和整体的昼夜控制
Ziyan Wang,Bradley M Bartholomai,Bin Wang et al.
Ziyan Wang et al.
Circadian rhythms are pervasive among eukaryotes, and the underlying clocks share a common regulatory architecture-a negative feedback loop. A wealth of genetic and biochemical data underpin current perceptions of circadian oscillators but ...
Light-based modulation of astrocytic calcium for regulation of organelle dynamics and morphogenesis [0.03%]
光调控星形胶质细胞内钙离子浓度对细胞器动态及形态构建的影响
Lan Yang,Mikael Björklund,Cong Yi et al.
Lan Yang et al.
Astrocytes are essential for neuronal homeostasis, and synaptic modulation and development. While astrocytes exhibit distinct Ca2+ signaling patterns, decoding their physiological roles remains challenging because conventional approaches ge...
Correction: Sensory cilia: How molecular motors can shape ciliary tip organization and diversity [0.03%]
纠正：感觉纤毛：分子马达如何能够塑造纤毛末端的组织和多样性
Bénédicte Durand
Bénédicte Durand
PI(3)P regulates mitochondrial dynamics through EXC-5-dependent actin remodeling [0.03%]
PI(3)P通过EXC-5依赖的肌动蛋白重塑调节线粒体动力学
Sneha Hegde,Marc Germain
Sneha Hegde
Mitochondrial dynamics regulate mitochondrial activity through several pathways, but their coordination remains unclear. Zhao et al. (https://doi.org/10.1083/jcb.202508040) show that endosomal PI(3)P promotes CDC42-dependent actin polymeriz...
Chromosome segregation synchrony in S. pombe is noise limited and arises without positive feedback [0.03%]
模式生物粟酒裂殖酵母中的染色体分离同步性无需正反馈即可形成且受噪声影响较大
Wendi Williams,Kien Phan,Jing Chen et al.
Wendi Williams et al.
Anaphase is a key cell cycle transition that ensures faithful genome inheritance. At anaphase onset, sister chromatids separate abruptly and synchronously upon activation of the protease separase. Major cell cycle transitions often involve ...