The Rab GEF VINE couples phosphatase recruitment to GAP-mediated Rab5 inactivation
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Rab5-family GTPases cycle between active and inactive forms to regulate endosomal membrane identity and protein trafficking. VPS9-family guanine nucleotide exchange factors (GEFs) promote Rab activation at endosomes, whereas GTPase-activating proteins (GAPs) o... ...
