No fuzzy space for intracellular Na+ in healthy ventricular myocytes [0.03%]
健康室肌细胞内不存在含糊的胞浆钠离子空间分布状态
Frank B Sachse,Robert Clark,Wayne R Giles
Frank B Sachse
Sachse et al. highlight work that reveals a Na+-dependent inactivation mechanism in the Na+/K+ pump.
Caitlin Sedwick
Caitlin Sedwick
New JGP study shows how calcium events drive long intestinal slow wave plateaus. © 2017 Rockefeller University Press.
Elevated cAMP improves signal-to-noise ratio in amphibian rod photoreceptors [0.03%]
提高cAMP可增大两栖类杆状感光细胞的信号与噪声的比例
Luba A Astakhova,Darya A Nikolaeva,Tamara V Fedotkina et al.
Luba A Astakhova et al.
The absolute sensitivity of vertebrate retinas is set by a background noise, called dark noise, which originates from several different cell types and is generated by different molecular mechanisms. The major share of dark noise is produced...
Na/K pump inactivation, subsarcolemmal Na measurements, and cytoplasmic ion turnover kinetics contradict restricted Na spaces in murine cardiac myocytes [0.03%]
钠泵失活、次sarcolemmal钠测量以及细胞质离子周转动力学与小鼠心肌细胞中的受限钠空间相矛盾
Fang-Min Lu,Donald W Hilgemann
Fang-Min Lu
Decades ago, it was proposed that Na transport in cardiac myocytes is modulated by large changes in cytoplasmic Na concentration within restricted subsarcolemmal spaces. Here, we probe this hypothesis for Na/K pumps by generating constituti...
Clustering of Ca2+ transients in interstitial cells of Cajal defines slow wave duration [0.03%]
间质细胞中Ca2+瞬变的聚类定义了慢波的持续时间
Bernard T Drumm,Grant W Hennig,Matthew J Battersby et al.
Bernard T Drumm et al.
Interstitial cells of Cajal (ICC) in the myenteric plexus region (ICC-MY) of the small intestine are pacemakers that generate rhythmic depolarizations known as slow waves. Slow waves depend on activation of Ca2+-activated Cl- channels (ANO1...
Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels [0.03%]
解读原核生物钠通道新型互作基序的功能作用
Altin Sula,B A Wallace
Altin Sula
Voltage-gated sodium channels enable the translocation of sodium ions across cell membranes and play crucial roles in electrical signaling by initiating the action potential. In humans, mutations in sodium channels give rise to several neur...
Caitlin Sedwick
Caitlin Sedwick
New JGP paper explains sexual dimorphism and tissue-specific activity of TRPV4. © 2017 Rockefeller University Press.
Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors [0.03%]
AMPA和NMDA受体中周边跨膜片段的发散作用
Johansen B Amin,Catherine L Salussolia,Kelvin Chan et al.
Johansen B Amin et al.
Ionotropic glutamate receptors (iGluRs), including AMPA receptor (AMPAR) and NMDA receptor (NMDAR) subtypes, are ligand-gated ion channels that mediate signaling at the majority of excitatory synapses in the nervous system. The iGluR pore d...
Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes [0.03%]
PKCα受体支架蛋白AKAP150与TRPV4通道间的距离限制及其在动脉肌细胞中的活化作用
Sendoa Tajada,Claudia M Moreno,Samantha O&#x;Dwyer et al.
Sendoa Tajada et al.
TRPV4 (transient receptor potential vanilloid 4) channels are Ca2+-permeable channels that play a key role in regulating vascular tone. In arterial myocytes, opening of TRPV4 channels creates local increases in Ca2+ influx, detectable optic...
Jeffrey Noebels
Jeffrey Noebels
Ion channel genes, originally implicated in inherited excitability disorders of muscle and heart, have captured a major role in the molecular diagnosis of central nervous system disease. Their arrival is heralded by neurologists confounded ...