Adam Feher,Geraldo Jorge Domingos,Martina Piga et al.
Adam Feher et al.
A recent publication by our research team has introduced a novel group of hHv1 inhibitors, the 5-phenyl-2-aminoimidazoles. To guide rational drug design of selective derivatives, our goal was to map the molecular mechanism of compound 13 (i...
Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents [0.03%]
不同FGF-A同源物介导的长时程失活对异源表达NaV1.2电流的影响
Yenisleidy Lorenzo-Ceballos,Pedro L Martinez-Espinosa,Xiao-Ming Xia et al.
Yenisleidy Lorenzo-Ceballos et al.
A-isoforms of cytosolic growth factor homologous factors (FGF11-14) mediate long-term inactivation (LTI) of voltage-dependent sodium (NaV) channels. LTI is a rapid onset process that is competitive with the fast inactivation (IF) intrinsic ...
Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics [0.03%]
眼部表面离子和水分转运模型预测干眼症疗法的有效性
Varun Verma,Ethan S Lindgren,Marc H Levin et al.
Varun Verma et al.
The composition and volume of tear fluid lining the ocular surface are governed by the rates of lacrimal gland secretion, tear film evaporation, nasolacrimal drainage, and epithelial ion and water transport. Tear fluid hyperosmolality and r...
Subunit composition of the KATP channels that modulate contractility of skeletal muscle during fatigue [0.03%]
疲劳期间调节骨骼肌收缩性的KATP通道的亚基组成
Rosa Scala,Yuezhou Chen,Berk Mizrak et al.
Rosa Scala et al.
ATP-sensitive potassium (KATP) channels are among the most expressed ion channels in skeletal muscle sarcolemma. While all KATP subunits can be detected in skeletal muscles, transcripts are enriched for KCNJ11 and ABCC9, suggesting that non...
Structural determinants at KCNE4 position 145 govern Kv1.3 channel function [0.03%]
KCNЕ4第145位的结构决定簇可调控Kv1.3通道的功能
Magalí Colomer-Molera,Daniel Sastre,Antonio Felipe
Magalí Colomer-Molera
Kv1.3 channels participate in the activation and proliferation of leukocytes. The KCNE4 regulatory subunit associates with the channel and functions as a negative regulator. KCNE4, via its transmembrane and C-terminal domains, interacts wit...
Dysferlin's C2A domain supports normal Ca2+ signaling and membrane repair in dysferlin-null myofibers [0.03%]
C2A结构域支持异世蛋白缺陷肌纤维的正常钙信号转导和膜修复功能
Valeriy Lukyanenko,Joaquin Muriel,Kassidy K Banford et al.
Valeriy Lukyanenko et al.
Dysferlin is required for the health of skeletal muscle, where it mediates at least two seemingly distinct processes, repair of the sarcolemmal membrane and stabilization of Ca2+ release after injury. Dysferlin is a ∼230-kDa protein compri...
Brain voltage-gated Ca2+ channels and calmodulin: Teaming up in calmodulinopathies? [0.03%]
电压门控钙通道和钙调素：在钙调素病中的相互作用？
Jörg Striessnig
Jörg Striessnig
Calmodulin (CaM) serves as one of the key cellular Ca2+ sensors with >300 targets and a highly conserved structure since its appearance in early eukaryogenesis. Three distinct CaM genes (CALM1, CALM2, and CALM3) encode one identical CaM pro...
Evolution of our understanding of the sodium channel fast inactivation: From Hodgkin and Huxley to the structural era [0.03%]
从霍奇金和赫克斯利到结构时代：钠通道快速失活研究认识的演变
Yichen Liu,Cesar A Amaya-Rodriguez,Victoria Collio et al.
Yichen Liu et al.
Voltage-gated sodium (Nav) channels enable the rapid influx of sodium ions that are essential to generating the rising phase of the action potential. As originally described by Hodgkin and Huxley, once the Nav channel is activated, it switc...
Extrinsic inputs underscore heterogeneities of ELL pyramidal cell neural activity in awake, behaving weakly electric fish [0.03%]
外源性输入强调了醒着的行为弱电鱼ELL锥体细胞神经活动的异质性
Amin Akhshi,Myriah Haggard,Mariana M Marquez et al.
Amin Akhshi et al.
Heterogeneity in spiking activity is ubiquitous among neurons even within a given cell type. To date, the relative contributions of extrinsic mechanisms (e.g., synaptic bombardment), intrinsic mechanisms (e.g., conductances), and cell morph...
John W Hussey,Emily DeMarco,Deborah DiSilvestre et al.
John W Hussey et al.
Calmodulinopathies are caused by mutations in calmodulin (CaM) and result in debilitating cardiac arrythmias such as long-QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). In addition, many patients exhibi...