Voltage-gated sodium channels: Mechanisms, disease, and a growing research community [0.03%]
电压门控钠通道：机制、疾病及日益增长的研究人群
Hugues Abriel,Angelika Lampert
Hugues Abriel
In this special issue of the Journal of General Physiology (JGP), we bring together a collection of studies that exemplify the multidimensional progress in physiology, pharmacology, and structure-function analysis of voltage-gated sodium (N...
Cortical spreading depression dynamics are altered by topical D2 receptor ligands [0.03%]
D2受体配体经皮给药可改变皮层扩散抑制的动态过程
Sonia Carolina Guerrero Prieto,Michael Cabrera Baez,Rubem Carlos Araújo Guedes
Sonia Carolina Guerrero Prieto
Cortical spreading depression (CSD) is a transient wave of neuronal and glial depolarization that propagates slowly through the cerebral cortex and is implicated in neurological events such as migraine aura. While glutamate, GABA, and serot...
Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice [0.03%]
Cantú综合征小鼠中由SUR2-但不是Kir6.1介导的内在性肌疲劳增加模型的研究
Rosa Scala,Maya Mukadam,Yuezhou Chen et al.
Rosa Scala et al.
Cantu syndrome (CS) is a rare disease caused by gain-of-function (GOF) mutations of Kir6.1 or SUR2 subunits of ATP-sensitive potassium (KATP) channels. CS patients with SUR2 and Kir6.1 variants display a similar constellation of symptoms, i...
PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating [0.03%]
PIP2驱动的细胞质区运动与Kir2通道门控相耦合
Eva-Maria Zangerl-Plessl,Anna Stary-Weinzinger,Colin G Nichols et al.
Eva-Maria Zangerl-Plessl et al.
Inwardly rectifying potassium (Kir) channel activity is important in the control of membrane potentials in both excitable and non-excitable cells and is regulated through various ligands, including specific membrane lipids. Phosphatidyl-4,5...
Adriano Senatore,Tatiana D Mayorova,Luis A Yañez-Guerra et al.
Adriano Senatore et al.
The sodium leak channel NALCN, a key regulator of neuronal excitability, associates with three ancillary subunits that are critical for its function: a subunit called FAM155, which interacts with the extracellular regions of the channel, an...
Investigating the role of the I-II linker in Nav1.5 channel function [0.03%]
I-II连接子在Nav1.5通道功能中的作用研究
Emily Wagner,Martina Marras,Shashi Kumar et al.
Emily Wagner et al.
The cardiac voltage-gated sodium channel, Nav1.5, initiates the cardiac action potential. Its dysfunction can lead to dangerous arrhythmias, sudden cardiac arrest, and death. The functional Nav1.5 core consists of four homologous repeats (I...
Shane R Nelson
Shane R Nelson
Cardiac contractility is driven by shortening of ∼2-μm-long, macromolecular assemblies known as sarcomeres. During contraction, the motor protein myosin binds to, and exerts force upon actin filaments, utilizing energy from the hydrolysis...
GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle [0.03%]
GSK3β介导的ABLIM1磷酸化调控其与心肌titin相互作用
Bin Sun,Alec Loftus,Brandon Beh Goh Beh et al.
Bin Sun et al.
The heart adapts to cardiac demand via chemical modifications of contractile myofilament proteins. Many of these modifications, such as phosphorylation, occur in proteins' intrinsically disordered regions (IDRs). These IDRs, though challeng...
Ben Short
Ben Short
JGP study (Woods et al. https://doi.org/10.1085/jgp.202413679) suggests that stretch activation of fast-contracting skeletal muscle fibers might increase muscle endurance by boosting force production during fatigue. ...
Exploring a peripheral PIP2-binding site and its role in the alternative regulation of the TRP channel superfamily [0.03%]
探索TRP通道超家族的外周PIP2结合位点及其在替代调节中的作用
L Gonzalo Espinoza-Arcos,Mariela González-Avendaño,Matías Zuñiga-Bustos et al.
L Gonzalo Espinoza-Arcos et al.
Phosphatidylinositol 4,5-bisphosphate (PIP2) is recognized as an essential modulator of transient receptor potential (TRP) channels. Specifically, it influences the vanilloid receptor I (TRPV1), a pain receptor activated by a wide range of ...