Ben Short
Ben Short
JGP study (Colmano et al. https://doi.org/10.1085/jgp.202513959) identifies passive leak currents as a likely common mechanism underlying hypomagnesemia with treatment-resistant seizures in patients with certain mutations in the Na+, K+-ATP...
A TMEM63B variant with enhanced mechanosensitive channel activity and acquired lipid scramblase function [0.03%]
一种具有增强机械敏感性通道活性和获得脂质转运酶功能的TMEM63B变异体
Augustus J Lowry,Pengfei Liang,Maria A Gonzalez Torres et al.
Augustus J Lowry et al.
TMEM63B, a mechanosensitive ion channel (MSC), is associated with severe neurodevelopmental disorders, including severe early-onset developmental and epileptic encephalopathy. Structure-function studies have shown that TMEM63B pathogenic va...
Differential Na+ chelation underlies opposite effects of aconitine and bulleyaconitine on sodium channel permeation [0.03%]
钠离子螯合作用差异导致乌头碱和少川乌头碱对钠离子通道渗透作用的相反效应
Boris S Zhorov
Boris S Zhorov
Voltage-gated sodium (Nav) channel site-2 diterpenoid alkaloids, including potent toxin aconitine (ACO), are generally considered gating modifiers that stabilize activated/open conformations and impair fast inactivation. In contrast, the st...
Reorganization of the slide helix by cholesterol during KirBac1.1 channel inactivation in membranes [0.03%]
胆固醇介导的KirBac1.1通道失活过程中膜上滑动螺旋的重构
Arpan Bysack,H Raghuraman
Arpan Bysack
KirBac1.1 is a prokaryotic homolog of mammalian inward-rectifier potassium (Kir) channels, and the functional equilibrium of KirBac1.1 is highly dependent on the type of membrane lipids. Like Kir channels, KirBac1.1 activity is also inhibit...
Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies [0.03%]
KCNK3和KCNK9中的等效功能获得性变异及其在不同TASK两孔钾通道病中的作用
Kate M Crowther,Thibault R H Jouen-Tachoire,Peter Proks et al.
Kate M Crowther et al.
Gain-of-function (GoF) missense variants in the two-pore domain (K2P) K+ channel TASK-1 (KCNK3) result in developmental delay with sleep apnea (DDSA), a neurodevelopmental channelopathy, while loss-of-function (LoF) variants cause pulmonary...
Zhang Feng
Zhang Feng
A TM3-TM4 hydrophobic patch couples TM4 remodeling to TMEM16A channel gating and sheds light on TMEM16 family divergence. © 2026 Feng.
Giving structure meaning: Modelling the cellular synapse of excitation-contraction coupling in skeletal muscle [0.03%]
结构赋予意义：骨骼肌兴奋收缩偶联细胞突触模型
Werner Melzer
Werner Melzer
Ca2+-ions, stored in a muscle fiber's SR, are rapidly released during electrical activity of the cell membrane to activate force, a process termed excitation-contraction coupling (EC coupling). In this process, the narrow junctional gap bet...
Allosteric interactions between RyR channels justify intracellular Ca2+ release of skeletal muscle in quantitative detail [0.03%]
变构相互作用对骨骼肌细胞内Ca２⁺释放的定量解释提供了依据
Eduardo Rios,Gonzalo Pizarro
Eduardo Rios
This modeling study explains the intracellular Ca2+ release that controls contraction of skeletal muscles of mammals as emerging from a statistical ensemble of couplons. Couplons are constituted by identical sarcoplasmic reticulum RyR1 chan...
Madeleine R Howell,Rosalind J Xu,Adam E Cohen
Madeleine R Howell
Voltage-gated ion channels play important roles in many membrane-enclosed structures, including synaptic vesicles, endosomes, mitochondria, chloroplasts, viruses, and bacteria. Here, we study how compartment size and channel gating interact...
Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels [0.03%]
模式原核钾通道：预测能力及其与真核生物钾通道的相关性
Philipp A M Schmidpeter,Crina M Nimigean
Philipp A M Schmidpeter
Prokaryotic ion channels have played a foundational role in defining the structural and mechanistic principles of potassium channel function. Beyond their historical importance, we argue that bacterial channels retain, even today, predictiv...