GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle [0.03%]
GSK3β介导的ABLIM1磷酸化调控其与心肌titin相互作用
Bin Sun,Alec Loftus,Brandon Beh Goh Beh et al.
Bin Sun et al.
The heart adapts to cardiac demand via chemical modifications of contractile myofilament proteins. Many of these modifications, such as phosphorylation, occur in proteins' intrinsically disordered regions (IDRs). These IDRs, though challeng...
Ben Short
Ben Short
JGP study (Woods et al. https://doi.org/10.1085/jgp.202413679) suggests that stretch activation of fast-contracting skeletal muscle fibers might increase muscle endurance by boosting force production during fatigue. ...
Exploring a peripheral PIP2-binding site and its role in the alternative regulation of the TRP channel superfamily [0.03%]
探索TRP通道超家族的外周PIP2结合位点及其在替代调节中的作用
L Gonzalo Espinoza-Arcos,Mariela González-Avendaño,Matías Zuñiga-Bustos et al.
L Gonzalo Espinoza-Arcos et al.
Phosphatidylinositol 4,5-bisphosphate (PIP2) is recognized as an essential modulator of transient receptor potential (TRP) channels. Specifically, it influences the vanilloid receptor I (TRPV1), a pain receptor activated by a wide range of ...
Gustavo Frindt,Shujie Shi,Trine Krogh-Madsen et al.
Gustavo Frindt et al.
The epithelial Na channel (ENaC) is a heterotrimer whose trafficking to the apical membrane is stimulated by aldosterone. Trafficking is associated with proteolytic cleavage of the α and γ subunits. We examined the kinetics of this proces...
Stretch activation combats force loss from fatigue in fast-contracting mouse skeletal muscle fibers [0.03%]
拉伸激活对抗疲劳引起的快速收缩小鼠骨骼肌纤维力的丧失
Philip C Woods,Douglas M Swank,Mark S Miller
Philip C Woods
Stretch activation (SA) is the delayed increase in force following a rapid stretch and improves muscle performance during repetitive cyclical contractions in insect flight and cardiac muscles. Although historically considered too low to be ...
Charybdotoxin binding to Shaker K+ channels is temperature sensitive in high external K+ but not in high external Na [0.03%]
外Na+和外K+对胆毒素与Shaker钾通道结合的温度敏感性的影响不同
Nieves Navarro-Quezada,Francisca Salas-Sepulveda,Horacio Poblete et al.
Nieves Navarro-Quezada et al.
Charybdotoxin (CTX), a peptide neurotoxin derived from the scorpion Leiurus quinquestriatus, binds to the external entrance of open voltage-gated K+ channels (VGKCs) with minimal conformational impact. By occluding the VGKC pore, CTX blocks...
GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains [0.03%]
GRIN2B疾病相关突变会破坏BK通道和N-甲基-D天冬氨酸受体信号纳米区域的功能
Rebeca Martínez-Lázaro,Teresa Minguez-Viñas,Andrea Reyes-Carrión et al.
Rebeca Martínez-Lázaro et al.
Large conductance calcium-activated potassium channels (BK channels) are unique in their ability to respond to two distinct physiological stimuli: intracellular Ca2+ and membrane depolarization. In neurons, these channels are activated thro...
Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation [0.03%]
电压感应器门控电荷的双峰调节作用调控钙通道激活的电压依赖性和动力学特性
Martin C Heiss,Monica L Fernández-Quintero,Marta Campiglio et al.
Martin C Heiss et al.
Voltage-sensing domains (VSDs) are highly conserved protein modules that regulate the activation of voltage-gated ion channels. In response to membrane depolarization, positive gating charges in the S4 helix of VSDs move across the membrane...
Correction: The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses [0.03%]
更正：内陷棒突触的结构减缓了谷氨酸扩散并塑造突触反应
Wallace B Thoreson,Thomas M Bartol,Nicholas H Conoan et al.
Wallace B Thoreson et al.
Colleen E Clancy
Colleen E Clancy
The function of the heart depends critically on the precise timing and coordination of electrical signals generated by ion channels in cardiac cells. The voltage-gated sodium current (INa) plays a pivotal role in initiating the rapid depola...