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Exploring a peripheral PIP2-binding site and its role in the alternative regulation of the TRP channel superfamily

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Phosphatidylinositol 4,5-bisphosphate (PIP2) is recognized as an essential modulator of transient receptor potential (TRP) channels. Specifically, it influences the vanilloid receptor I (TRPV1), a pain receptor activated by a wide range of stimuli, including t... ...