Kyle D Berger,David M MacLean
Kyle D Berger
Acid-sensing ion channels (ASICs) are trimeric cation-selective channels activated by extracellular acidification. Amongst many pathological roles, ASICs are an important mediator of ischemic cell death and hence an attractive drug target f...
Eve Marder
Eve Marder
The knowledge in our brains, not in our phones, is necessary for creative thinking and the pursuit of truth.
Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina [0.03%]
光诱导快速增加蛙视网膜棒外节中的cAMP并激活PKA
Olga Chernyshkova,Natalia Erofeeva,Darya Meshalkina et al.
Olga Chernyshkova et al.
The phototransduction cascade enables the photoreceptor to detect light over a wide range of intensities without saturation. The main second messenger of the cascade is cGMP and the primary regulatory mechanism is calcium feedback. However,...
Ben Short
Ben Short
Two JGP studies (Sanchez et al. https://doi.org/10.1085/jgp.202313502; Kraujaliene et al. https://doi.org/10.1085/jgp.202413600) reveal how small differences in a pore-lining region alter both the gap junction and hemichannel function of co...
Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain [0.03%]
Nav1.8通道与Nav1.7通道的相互作用驱动神经病理性疼痛中的神经元过度兴奋
Dmytro V Vasylyev,Peng Zhao,Betsy R Schulman et al.
Dmytro V Vasylyev et al.
While voltage-gated sodium channels Nav1.7 and Nav1.8 both contribute to electrogenesis in dorsal root ganglion (DRG) neurons, details of their interactions have remained unexplored. Here, we studied the functional contribution of Nav1.8 in...
The artificial intelligence revolution...in unethical publishing: Will AI worsen our dysfunctional publishing system? [0.03%]
人工智能革命……在不道德的出版业中：人工智能会令我们的出版系统变得更糟糕吗？
Thiago F A França,José Maria Monserrat
Thiago F A França
Scholarly publishing has been shaped by the pressure of a liquid economy to become an exercise in branding more than a vehicle for the advancement of science. The current revolution in artificial intelligence (AI) is poised to make matters ...
Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle [0.03%]
肌球蛋白结合蛋白H在发育性脊椎动物快肌 twitch 纤维中的功能作用
Andrew F Mead,Neil B Wood,Shane R Nelson et al.
Andrew F Mead et al.
Myosin-binding protein H (MyBP-H) is a component of the vertebrate skeletal muscle sarcomere with sequence and domain homology to myosin-binding protein C (MyBP-C). Whereas skeletal muscle isoforms of MyBP-C (fMyBP-C, sMyBP-C) modulate musc...
Ben Short
Ben Short
This JGP study (Collaço et al. https://doi.org/10.1085/jgp.202413563) reveals that in addition to voltage-gated Ca2+ and K+ channels, ω-grammotoxin-SIA also inhibits voltage-gated Na+ channel currents. ...
An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities [0.03%]
E1中的Ala/Glu差异影响Cx26和Cx30的带负电荷的化合物通透性差异
Lina Kraujaliene,Tadas Kraujalis,Mindaugas Snipas et al.
Lina Kraujaliene et al.
Two closely related connexins, Cx26 and Cx30, share widespread expression in the cochlear cellular networks. Gap junction channels formed by these connexins have been shown to have different permeability profiles, with Cx30 showing a strong...
A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function [0.03%]
E1胞孔节段中一个调控Cx26和Cx30半通道功能的位点
Helmuth A Sanchez,Lina Kraujaliene,Vytas K Verselis
Helmuth A Sanchez
Connexins (Cxs) function as gap junction (GJ) channels and hemichannels that mediate intercellular and transmembrane signaling, respectively. Here, we investigated the proximal segment of the first extracellular loop, E1, of two closely rel...