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A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function

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Connexins (Cxs) function as gap junction (GJ) channels and hemichannels that mediate intercellular and transmembrane signaling, respectively. Here, we investigated the proximal segment of the first extracellular loop, E1, of two closely related Cxs, Cx26 and C... ...