Reduced voltage-activated Ca2+ release flux in muscle fibers from a rat model of Duchenne dystrophy [0.03%]
杜氏肌营养不良大鼠模型肌肉纤维中电压依赖性Ca２＋释放通量的降低
Jonathan Schreiber,Ludivine Rotard,Yves Tourneur et al.
Jonathan Schreiber et al.
The potential pathogenic role of disturbed Ca2+ homeostasis in Duchenne muscular dystrophy (DMD) remains a complex, unsettled issue. We used muscle fibers isolated from 3-mo-old DMDmdx rats to further investigate the case. Most DMDmdx fiber...
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers [0.03%]
六聚体和七聚体pannexin 1通道连接多聚体的特性及其激活方式的区别研究
Smriti Gupta,Yu-Hsin Chiu,Mohan C Manjegowda et al.
Smriti Gupta et al.
Pannexin 1 (PANX1) is a member of a topologically related and stoichiometrically diverse family of large pore membrane ion channels that support the flux of signaling metabolites (e.g., ATP) and fluorescent dyes. High-resolution structural ...
Correction: Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors [0.03%]
关于胆碱能受体中变构作用结构基础理解的更正：肌肉型乙酰胆碱受体为例
Wessel A C Burger,Patrick M Sexton,Arthur Christopoulos et al.
Wessel A C Burger et al.
How does mitochondrial Ca2+ change during ischemia and reperfusion? Implications for activation of the permeability transition pore [0.03%]
缺血再灌注过程中线粒体钙离子如何变化？其活化渗透性转换孔的机制与意义是什么？
Elizabeth Murphy,David A Eisner
Elizabeth Murphy
Cardiac ischemia followed by reperfusion results in cardiac cell death, which has been attributed to an increase of mitochondrial Ca2+ concentration, resulting in activation of the mitochondrial permeability transition pore (PTP). Evaluatin...
Ben Short
Ben Short
JGP study (Liu and Bezanilla. https://doi.org/10.1085/jgp.202413667) reveals that a sodium channel mutant blocks fast inactivation downstream of inactivation particle binding, diverting the channel into an alternative open state. ...
Lisa A McIlvried,John Smith Del Rosario,Melanie Y Pullen et al.
Lisa A McIlvried et al.
In response to changes in activity induced by environmental cues, neurons in the central nervous system undergo homeostatic plasticity to sustain overall network function during abrupt changes in synaptic strengths. Homeostatic plasticity i...
Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites [0.03%]
钠通道α亚基异构体的N连接糖基化改变β亚基结合位点
Christopher A Beaudoin,Manas Kohli,Samantha C Salvage et al.
Christopher A Beaudoin et al.
Voltage-gated sodium channel α-subunits (NaV1.1-1.9) initiate and propagate action potentials in neurons and myocytes. The NaV β-subunits (β1-4) have been shown to modulate α-subunit properties. Homo-oligomerization of β-subunits on ne...
Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy [0.03%]
FKBP12丢失在扩张型心肌病发生发展中的时间依赖效应
Joan A Chan,Michelle L Munro
Joan A Chan
Hanna et al. reveal that early, but not late, developmental cardiac FKBP12 deficiency leads to dilated cardiomyopathy in the adult heart.
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency [0.03%]
FKBP12缺乏相关扩张型心肌病的发病机制研究
Amy D Hanna,Ting Chang,Kevin S Ho et al.
Amy D Hanna et al.
Dilated cardiomyopathy (DCM) is a highly prevalent and genetically heterogeneous condition that results in decreased contractility and impaired cardiac function. The FK506-binding protein FKBP12 has been implicated in regulating the ryanodi...
A sodium channel mutant removes fast inactivation with the inactivation particle bound [0.03%]
快速失活粒子结合体中钠离子通道突变体的快速失活消失
Yichen Liu,Francisco Bezanilla
Yichen Liu
Fast inactivation is a key feature of voltage-gated sodium channels and is pivotal for countless physiological functions. Despite the prevalence of the canonical ball-and-chain model, more recent structural results suggest that fast inactiv...