Broad-Spectrum Drug Screening Positivity Rates in Pediatrics and Adults: The Reference Laboratory Perspective [0.03%]
参考实验室视角下的儿科和成人广谱药物筛查阳性率
Ryan C Shean,Kamisha L Johnson-Davis
Ryan C Shean
Background: Broad-spectrum drug testing is useful in various practical settings, especially when patients present with unknown exposures. Although national poison control data inform trends in toxicity and poison control ...
Methylene Blue-Induced False-Positive Amphetamine Results in Urine Drug Screening: Two Case Reports [0.03%]
美蓝引起尿液毒品筛查假阳性苯丙胺结果两例报告
Emiel Leegwater,Nynke G L Jager
Emiel Leegwater
Development and Evaluation of Multimodel Informed Precision Dosing Tool for Optimizing Vancomycin Therapy in Pediatric Patients [0.03%]
一种儿科万古霉素治疗的多模型精确给药工具的研发与评估
Yawen Yuan,Li Xu,Yueling Xi et al.
Yawen Yuan et al.
Background: The narrow therapeutic window and high pharmacokinetic (PK) variability of vancomycin may lead to trough concentrations outside the usual therapeutic range, requiring dose adjustments. In this study, we aimed ...
Cefepime Pharmacokinetics in Patients Receiving Extracorporeal Membrane Oxygenation [0.03%]
依达拉奉在体外膜氧合支持患者中的药代动力学研究
Nicole F Maranchick,Andrew Jaudon,Siya Aparanji et al.
Nicole F Maranchick et al.
Background: Data on the effect of extracorporeal membrane oxygenation (ECMO) on cefepime concentration and protein binding are limited. This study aimed to describe the pharmacokinetics of cefepime in patients receiving E...
Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Quantification of Four Endocannabinoids and Endocannabinoid-Like Substances in Plasma: Application in an HIV-Hepatitis C Virus Coinfected Population [0.03%]
一种用于同时定量血浆中四种内源性大麻素和类似物的液相色谱-串联质谱法及其在HIV-丙型肝炎病毒共感染人群中的应用
Alexandr Gish,Eqbal Radwan,Camille Richeval et al.
Alexandr Gish et al.
Background: The endocannabinoid system regulates immune function, inflammation, and metabolism and has gained increasing attention in clinical research. However, the instability, low abundance, and physicochemical complex...
Limited Sampling Strategy of Rosuvastatin Single-Time-point Concentrations Accurately Estimate Exposure and Constitutive Transporter Activities in Healthy Adults [0.03%]
限采样策略可准确估算健康成人阿托伐他单时间点浓度暴露及构成转运蛋白活性
Ryan Barry,Catherine Liu,Mary F Paine et al.
Ryan Barry et al.
Background: Rosuvastatin is commonly used as an exogenous probe drug to evaluate the activities of organic anion-transporting polypeptide (OATP) 1B1/3 and breast cancer resistance protein (BCRP). The authors evaluated a l...
Simultaneous Quantification of Dexamethasone and Cortisol for the Dexamethasone Suppression Test Using LC-MS/MS: Adaptation of a Commercial CE-IVD Steroid Assay [0.03%]
一种商业CE-IVD皮质类固醇测定法在液相色谱-串联质谱法中用于地塞米松抑制试验中的地塞米松和皮质醇的同时定量分析中的应用
Regula Steiner,Marc Luginbühl
Regula Steiner
Background: The dexamethasone suppression test (DST) is a key diagnostic tool for evaluating disorders of the hypothalamic-pituitary-adrenal (HPA) axis. Interpretation of DST results can be confounded by inadequate dexame...
Cyclosporin A Monitoring in Allogeneic Hematopoietic Stem-Cell Transplant Recipients: A Comparison Between Siemens Viva-ProE System and LC-MS/MS [0.03%]
西门子Viva-ProE系统与LC-MS/MS监测同种异体造血干细胞移植受者的环孢素A的比较
Rongqi Lin,Xianghui Fan,Xueyong Li et al.
Rongqi Lin et al.
Background: Allogeneic hematopoietic stem-cell transplantation is a critical treatment for blood-related diseases often complicated by graft-versus-host disease and managed using cyclosporin A (CsA). Therapeutic drug moni...
Simultaneous Quantification of Azole Antimycotics in Quantitative Dried Blood Spots: A Step Toward Home Sampling for Therapeutic Drug Monitoring [0.03%]
用于治疗药物监测的家庭采样定量血斑中唑类抗真菌药的同时测定步奏
Shengbin Li,Boyu Liu,Jinghua Yuan et al.
Shengbin Li et al.
Background: Home sampling for therapeutic drug monitoring (TDM) shows promise as a valuable tool, particularly for stable patients with limited access to health care. Quantitative dried blood spot (qDBS) technology has em...
Correlation Between Escitalopram, Sertraline, and Fluoxetine Serum Levels and QTc Interval Prolongation in Children and Adolescents [0.03%]
艾司西酞普兰、舍曲林和氟西汀血药浓度与儿童及青少年QTc间期延长的相关性研究
Wiebke Warrings,Regina Taurines,Karin Egberts et al.
Wiebke Warrings et al.
Background: Selective serotonin reuptake inhibitors, including escitalopram, sertraline, and fluoxetine, are frequently prescribed to treat depression and anxiety and obsessive-compulsive disorders in pediatric population...