High-throughput UHPLC-MS/MS Assay for the Quantification of Venetoclax in Patients with Acute Myeloid Leukemia and Assessment of Clinical Application: A Short Communication [0.03%]
高 throughput UHPLC-MS/MS测定急性髓系白血病患者维奈克拉浓度及临床应用评估：简讯
Yuri Hatano,Ken Shiraiwa,Ryota Tanaka et al.
Yuri Hatano et al.
Background: Venetoclax is a B-cell lymphoma 2 inhibitor with breakthrough therapy designations and is used in the treatment of acute myeloid leukemia, particularly in patients ineligible for conventional cytotoxic chemoth...
A Retrospective Analysis of Itraconazole and Hydroxy-Itraconazole Serum Concentrations Correlation to Clinical Outcomes of Histoplasmosis Treatment [0.03%]
伊曲康唑和羟基伊曲康唑血药浓度与ヒ斯塔孢子菌病治疗临床结局相关性的回顾性分析
Danielle Firkus,Ryan W Stevens,Omar M Abu Saleh et al.
Danielle Firkus et al.
Background: Itraconazole is the preferred antifungal agent for mild to moderate histoplasmosis and step-down therapy following amphotericin B treatment. Although hydroxy-itraconazole, a major metabolite of itraconazole, d...
Apparent Elevation of Whole-Blood Tacrolimus Concentrations Following High-Dose Intravenous Immunoglobulin Therapy in Kidney Transplant Recipients [0.03%]
肾移植受者接受大剂量静脉注射免疫球蛋白治疗后全血他克莫司浓度相对升高现象
Takashi Tsujimoto,Hajime Sasaki,Toyoshi Seito et al.
Takashi Tsujimoto et al.
Background: The effect of massive immunoglobulin G (IgG) elevation on highly protein-bound tacrolimus (TAC) after high-dose intravenous immunoglobulin (IVIG) therapy remains uncharacterized. Misinterpreting IVIG-induced w...
Construction and Validation of a Model for Predicting Antidepressant Treatment Outcomes in Patients with Depression by Monitoring Both Paroxetine Plasma Concentration and Dynamic SIRT1 Expression in Peripheral Blood [0.03%]
通过监测帕罗西汀血药浓度及外周血SIRT1动态表达构建预测抑郁症抗抑郁治疗结局的模型及其验证
Xiaoya Wen,Chengxiang Hou,Yin Yao et al.
Xiaoya Wen et al.
Background: Paroxetine efficacy cannot be accurately predicted through TDM alone. Given SIRT1's linkage to drug response, we explored the predictive value of combined TDM and SIRT1 detection.Methods: In total, 27 treatmen...
Evaluation of Model-Informed Precision Dosing of Cefepime in Critically Ill Patients: A French Before-After Study [0.03%]
头孢吡肟基于模型的个体化给药在重症患者中的疗效评估：一项法国前后对照研究
Giuseppe Balice,Soizic Percevault,Sabine Cohen et al.
Giuseppe Balice et al.
Background: Cefepime is widely used in intensive care units for the treatment of complicated gram-negative infections. Owing to its concentration-dependent neurological toxicity, cefepime is a candidate for therapeutic dr...
Extended-Release Tacrolimus Versus LifeCycle Pharma Tacrolimus in Kidney Transplant Recipients: A Switch Study [0.03%]
接受扩展释放型他克莫司与Lifecyle制药他克莫司的肾移植受者的转换研究
Nienke A Manson,Emma H C van Schijndel,Theodora S M Standaar et al.
Nienke A Manson et al.
Background: Tacrolimus is a first-line immunosuppressant used in kidney transplantation. However, its narrow therapeutic window and variable exposure present challenges. Extended- and prolonged-release formulations, ER-ta...
Mapping Therapeutic Drug Monitoring Research in Low- and Middle-Income Countries: A Scoping Review (2015-2024) [0.03%]
低收入和中等收入国家治疗药物监测研究的范围审查（2015-2024）
Ronaldo Morales Junior,João P Telles,Nathalie G S Chua et al.
Ronaldo Morales Junior et al.
Background: Therapeutic drug monitoring (TDM) helps optimize pharmacotherapy, but research activity in low- and middle-income countries (LMICs) is poorly characterized. This scoping review systematically maps the volume, ...
Comparative Evaluation of Siemens Atellica and Abbott ARCHITECT Tacrolimus Immunoassays Against LC-MS/MS: A Short Communication [0.03%]
西门子Atellica和雅培ARCHITECT他克莫司免疫分析与LC-MS/MS对比评估：简短通讯
Rebecca J Wilson,Jason Gowans,Hillary Anderson et al.
Rebecca J Wilson et al.
Background: Tacrolimus is a critical immunosuppressant that requires therapeutic drug monitoring because of its narrow therapeutic index and erratic pharmacokinetics. Although liquid chromatography-tandem mass spectrometr...
Vancomycin-Induced AKI in Adult Patients With Oncological Diseases: Bridging Diagnostic Criteria Gaps With Tailored Dosing Strategies in a Prospective Cohort Study [0.03%]
成人肿瘤患者万古霉素诱导的急性肾损伤：一项前瞻性队列研究中针对诊断标准缺口的个体化治疗策略
Diogenes Coelho Jr,Karen Migotto,Diego Feriani da Silva et al.
Diogenes Coelho Jr et al.
Background: The aim of this study was to (1) determine the incidence of acute kidney injury (AKI) in patients with oncological diseases and identify its probable causes, (2) estimate the pharmacokinetic (PK) parameters in...
Serum-Level Profile of Tranexamic Acid and Development of Seizures in a Patient With End-Stage Renal Disease After Receiving Artificial Hip Replacement [0.03%]
终末期肾病患者接受人工髋关节置换术后氨甲环酸血清水平及癫痫发作风险
Daiki Tsunashima,Susumu Sakaue,Yumi Yoshikawa et al.
Daiki Tsunashima et al.
Background: The authors reported a 73-year-old woman with end-stage renal disease who underwent artificial hip replacement. Methods: Cl...