Development and Validation of Linear Regression Models to Predict Plasma-Free Perampanel Concentrations Using Routine Clinical Data [0.03%]
基于常规临床数据预测帕利普氨浓度的线性回归模型的开发与验证
Rena Yamaguchi,Tatsuya Yagi,Toshiaki Suzuki et al.
Rena Yamaguchi et al.
Background: Therapeutic drug monitoring of perampanel, a highly protein-bound antiseizure medication, is typically based on total plasma concentration (Cpt); however, free drug concentrations are more directly associated ...
Optimizing Initial Dosing for Tacrolimus and Mycophenolate in Living Donor Liver Transplantation: A Systematic Critical Review [0.03%]
Tacrolimus和吗替麦考酚酯在活体肝移植术中初始给药方案的系统评价及Meta分析：循证优化剂量的探索性研究
Kiara Bautista,Jeong Park
Kiara Bautista
Background: The pharmacokinetics (PK) of immunosuppressive agents in living donor liver transplantation (LDLT) recipients are expected to differ from those in deceased donor liver transplantation (DDLT) recipients because...
"Standard" Is More Than Enough: Therapeutic Drug Monitoring Confirms Early Target Attainment of Teicoplanin Regimens in Pediatric Patients [0.03%]
“标准”已经足够：血药浓度监测证实了替考拉宁在儿童患者中的早期达标治疗方案
Marcello Mariani,Alessia Cafaro,Silvia M Orsi et al.
Marcello Mariani et al.
Background: Therapeutic drug monitoring (TDM) is recommended for optimizing teicoplanin therapy, given its high pharmacokinetic variability. Recent literature suggests that standard dosing regimens are often insufficient ...
Effects of Switching From Smoking to Vaping on Clozapine Concentration-Dose Ratios and Plasma Clozapine Concentrations: A Systematic Review of Case Reports [0.03%]
从吸烟转换到吸电子烟对氯氮平浓度剂量比和血浆氯氮平浓度的影响：病例报告的系统性回顾
Somtochukwu D Uche,Deborah Robson,Hannah Walsh et al.
Somtochukwu D Uche et al.
Introduction: Smoking tobacco cigarettes affects the metabolism of several antipsychotic medications by inducing CYP1A2 enzymes. Clozapine is particularly sensitive to this effect, as CYP1A2 induction increases the plasma...
Biogeneric Native and Polyethylene Glycol-conjugated Escherichia coli Asparaginases for Treating Children with Acute Lymphoblastic Leukemia [0.03%]
生物类似物及聚乙二醇化的大肠埃希氏菌天冬酰胺酶治疗儿童急性淋巴细胞白血病的疗效和安全性：一项开放性非劣效性随机对照试验
Neerajana Datta,Bishwaranjan Jana,Srijani Goswami et al.
Neerajana Datta et al.
Background: Escherichia coli asparaginases (EcASNase) available for the treatment of children with acute lymphoblastic leukemia are largely of suboptimal quality in low-middle income countries and contribute to inferior o...
A Review of Blood-Based Microsampling Devices for Patient-Centered Application in Therapeutic Drug Monitoring [0.03%]
用于治疗药物监测的患者中心应用的基于血液的微量取样装置综述
Jonas M Huhn,Oliver Scherf-Clavel
Jonas M Huhn
Background: Microsampling devices simplify the collection, transport, and storage of biological samples, thereby playing an important role in therapeutic drug monitoring (TDM). This review summarizes the current developme...
Serum Aripiprazole Concentrations After Inadvertent Intradeltoid Administration of Aripiprazole Lauroxil 1064 mg: A Case Report [0.03%]
左乙拉西坦注射液意外错误给药后血清阿立哌唑浓度：个案报告
Erica A K Davis,Mark Mollenhauer
Erica A K Davis
Background: The FDA-approved package insert for aripiprazole lauroxil (AL) indicates that the 1064-mg dose should be administered as an intramuscular injection in the gluteal muscle every 8 weeks. Administration at differ...
Interpretive Reference Ranges for Plasma Drug Concentrations in Acute Recreational Drug Toxicity: A Short Communication [0.03%]
急性娱乐性药物中毒血药浓度解释参考范围的简短通讯
Stefania Boccuzzi,Dilek Battal,David Cowan et al.
Stefania Boccuzzi et al.
Background: Acute recreational drug toxicity (ARDT) is a frequent cause of emergency department presentations; however, clinicians lack guidance for interpreting drug concentrations. Existing terminology ("therapeutic," "...
A Performance Evaluation of Bayesian Forecasting for Serum Linezolid Concentrations: Impact of Clinical Factors on Prediction Accuracy [0.03%]
临床因素对血清利奈唑胺浓度贝叶斯预测准确性影响的性能评价
Naoaki Hashimoto,Yuji Wakimoto,Tomoka Kusama et al.
Naoaki Hashimoto et al.
Background: Pycsim, a dosing software for linezolid (LZD) based on Bayesian estimation, predicts dosing in the therapeutic drug monitoring (TDM) of LZD. However, its predictive performance, examined using an independent d...
Testing for hydroxyzine in human hair after a single controlled administration: First quantitative data [0.03%]
人一次性受控给药后检测头发中的羟嗪：首批定量数据
Nadia Arbouche,Laurie Gheddar,Jean-Sébastien Raul et al.
Nadia Arbouche et al.
Background: Hydroxyzine is a first-generation antihistamine widely prescribed for its anxiolytic and sedative effects and has been reported in cases of drug-facilitated crimes. To date, no data on hydroxyzine incorporatio...