Quantification of Multi-Organ 11β-Hydroxysteroid Dehydrogenase Type 1 Enzyme Levels in a Zucker Fatty Rat Model: A PET Imaging Study [0.03%]
大鼠脂肪模型多器官11β-羟基类固醇脱氢酶Ⅰ型水平的量化：正电子发射断层成像研究
Jason Bini,Jordan Strober,Michael Kapinos et al.
Jason Bini et al.
Background: In rodents, 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) catalyzes the conversion of inactive 11-dehydrocorticosterone to the active hormone corticosterone. Dysregulation of intracellular glucocorticoid act...
Preliminary Exploration of Al18F-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study [0.03%]
18F-Al-NOTA-FAPI-04 PET/CT在强直性脊柱炎中的应用初探：一项前瞻性临床研究
Shibo Guo,Zhehao Lyu,Chunyu Duan et al.
Shibo Guo et al.
Background: Ankylosing spondylitis (AS) is characterized by inflammation and osteoblastic changes in the sacroiliac joint. As a potential imaging method for the early assessment of AS, positron emission tomography (PET) c...
Effect of the TAAR1 Partial Agonist Ralmitaront on Presynaptic Dopamine Synthesis Capacity Measured Using [18F]DOPA PET in Naïve and Cocaine-Treated Mice [0.03%]
TAAR1部分激动剂Ralmitaront对初次和服用可卡因的小鼠使用[18F]DOPA PET测量的突触前多巴胺合成能力的影响
David R Bonsall,Michelle Kokkinou,Els F Halff et al.
David R Bonsall et al.
Purpose: Elevated dopamine synthesis capacity is part of the pathophysiology of schizophrenia thought to underlie psychosis. Drugs that reduce this phenomenon could thus be potential treatments for these disorders. In thi...
A Pharmacokinetic Model Determination of Time Activity Curves in Radiopharmaceutical Therapy [0.03%]
放射药物治疗中时间活性曲线的药代动力学模型决定
Joseph Steiner,Brandon Nguyen,Farhad Jafari
Joseph Steiner
Introduction and purpose: Radiopharmaceutical therapy (RPT) dosimetry can be challenging to perform due to sparse data measurements and variations in how the time activity curve (TAC) is determined. In this work, a single...
Homologous 111In-Radiolabeled Platelet Survival and Sequestration Exploration for Refractory Immunologic Thrombocytopenic purpura in Children: A Strategy to Avoid Unnecessary Splenectomy [0.03%]
儿童难治性免疫性血小板减少性紫癜的同位素111In标记血小板存活和滞留分布研究：一种避免不必要的脾切除的方法策略
Julien Dubois,Florentin Kucharczak,Léa De Neef et al.
Julien Dubois et al.
Immunologic thrombocytopenic purpura (ITP) is a condition that affects four to 18 per 100 000 children every year. In most cases, spontaneous remission occurs, but splenectomy may be proposed. Exploring the site of platelet sequestration ca...
In Situ Mapping of the Glucose Metabolism Heterogeneity in Atherosclerosis: Correlation With 2-Deoxyglucose Uptake [0.03%]
动脉粥样硬化局部糖代谢异质性分布的原位成像及其与葡萄糖摄取的相关性研究
Joseph Haddad,Selim Demirdelen,Clayton E Barnes et al.
Joseph Haddad et al.
Objective: 2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) is widely used for noninvasive imaging of atherosclerosis. However, knowledge about metabolic processes underlying [18F]FDG uptake is mostly derived from in vitro cell...
Comparison of Tumor Non-specific and PD-L1 Specific Imaging by Near-Infrared Fluorescence/Cerenkov Luminescence Dual-Modality In-situ Imaging [0.03%]
基于近红外荧光/契伦科夫冷光双模影像技术的肿瘤非特异性和PD-L1特异性成像对比研究
Linhan Zhang,Lianmeng Zhao,Xue Lin et al.
Linhan Zhang et al.
Background: Labeled antibodies are excellent imaging agents in oncology to non-invasively visualize cancer-related antigens expression levels. However, tumor tracer uptake (TTU) of specific antibodies in-vivo may be infer...
Comparative Study
Molecular imaging. 2024 Jun 14:23:15353508241261473. DOI:10.1177/15353508241261473 2024
Study on the Relationship Between MRI Functional Imaging and Multiple Immunohistochemical Features of Glioma: A Noninvasive and More Precise Glioma Management [0.03%]
基于MRI的功能影像与胶质瘤多免疫组织化学表型关系的研究：一种非侵入性更精准的胶质瘤诊疗策略
Jing Li,Jingtao Sun,Ning Wang et al.
Jing Li et al.
Objective: To investigate the performance of diffusion-tensor imaging (DTI) and hydrogen proton magnetic resonance spectroscopy (1H-MRS) parameters in predicting the immunohistochemistry (IHC) biomarkers of glioma. ...
PET/CT in the Evaluation of CAR-T Cell Immunotherapy in Hematological Malignancies [0.03%]
正电子发射断层扫描/计算机断层扫描在评估 CART 细胞免疫疗法治疗血液系统恶性肿瘤中的应用
Shashi B Singh,Sadikshya Bhandari,Shisir Siwakoti et al.
Shashi B Singh et al.
Chimeric antigen receptor (CAR)-T cell-based immunotherapy has emerged as a path-breaking strategy for certain hematological malignancies. Assessment of the response to CAR-T therapy using quantitative imaging techniques such as positron em...
Combining Nuclear Medicine With Other Modalities: Future Prospect for Multimodality Imaging [0.03%]
核医学与其它影像模态的融合：分子影像的未来方向
Stephen J Archibald,Jason P Holland,Aruna Korde et al.
Stephen J Archibald et al.
This meeting report summarizes a consultants meeting that was held at International Atomic Energy Agency Headquarters, Vienna, in July 2022 to provide an update on the development of multimodality imaging by combining nuclear medicine imagi...