Proteomic Analysis and 2-Hydroxyisobutyrylation Profiling in Metabolic Syndrome Induced Restenosis [0.03%]
代谢综合征诱导的再狭窄的蛋白质组分析及2-羟异丁酰化谱型测定
Xiangyu Liu,Liping Zhou,Wenjing Huang et al.
Xiangyu Liu et al.
Restenosis is the primary complication following stenting for coronary and peripheral arterial disease (PAD), posing an ongoing clinical challenge. Metabolic syndrome (MetS), characterized by metabolic disturbances, has been identified as a...
DExH-Box Helicase 9 (DHX9) Participates in De Novo Nrf2 Protein Translation under Oxidative Stress [0.03%]
DExH盒解旋酶9(DHX9)参与氧化应激下从头型Nrf2蛋白翻译
Wujing Dai,Hongting Diao,Han Qu et al.
Wujing Dai et al.
Nrf2 transcript factor plays an important role in cellular defense against oxidative stress due to its control for expression of antioxidant and detoxification genes. We have found that Nrf2 gene undergoes de novo protein translation when m...
Landscape of steroid dynamics in pregnancy - insights from the maternal-placental-fetal unit and placental models [0.03%]
妊娠甾体动态景观——来自母体-胎盘-胎儿体系和胎盘模型的见解
Rona Karahoda,Therina Du Toit,Barbara Fuenzalida et al.
Rona Karahoda et al.
Recent advances in analytical methods have revolutionized our understanding of steroid biochemistry. The emergence of novel steroids such as 11-oxy androgens and 11-oxy progesterones has necessitated a reevaluation of steroid biosynthesis a...
SysQuan: repurposing SILAC mice for the cost-effective absolute quantitation of the human proteome [0.03%]
SysQuan：再利用SILAC小鼠进行人类蛋白质组绝对定量的经济型方法
Yassene Mohammed,Vincent R Richard,M Immanuel Reyes Madlangsakay et al.
Yassene Mohammed et al.
Relative quantitation, used by most MS-based proteomics laboratories to determine protein fold-changes, requires samples being processed and analyzed together for best comparability through minimizing batch differences. This limits the adop...
Global analysis of protein and small-molecule substrates of ubiquitin-like proteins (UBLs) [0.03%]
泛素样蛋白(UBL)的底物的全球分析：蛋白质和小分子substrates
Guang-Can Shao,Zhen-Lin Chen,Shan Lu et al.
Guang-Can Shao et al.
Ubiquitin-like proteins (UBLs) constitute a family of evolutionarily conserved proteins that share similarities with ubiquitin in 3D structures and modification mechanisms. For most UBLs including Small-Ubiquitin-like Modifiers (SUMO), thei...
SIRT3 functions as an eraser of histone H3K9 lactylation to modulate transcription for inhibiting the progression of esophageal cancer [0.03%]
SIRT3通过擦除组蛋白H3K9乳酰化调控转录以抑制食管癌进展
Chen Chen,Yingao Zhang,Yong Zang et al.
Chen Chen et al.
Lysine lactylation (Kla) links lactate metabolism to epigenetic regulation, playing a key role in modulation of gene expression in tumor and immune microenvironment. Our recent study shows that HBO1-mediated histone H3K9la activates the tra...
Thermal proteome profiling reveals meltome upon NLRP3 inflammasome activation [0.03%]
热蛋白组分析揭示NLRP3炎症小体激活后的融化蛋白组状态
Chen Yang,Ling Wang,Yuchen Liu et al.
Chen Yang et al.
NLR family pyrin domain containing 3 (NLRP3) involves in inflammasome complex assembly and innate immunity. Activation of the NLRP3 inflammasome induces conformational alterations in protein complexes, influencing their interactions with ot...
Identification of post-translationally modified MHC class I-associated peptides as potential cancer immunotherapeutic targets [0.03%]
识别经后翻译修饰的MHCⅠ类关联肽作为潜在的癌症免疫治疗靶点
Keira E Mahoney,Larry Reser,Maria Virginia Ruiz Cuevas et al.
Keira E Mahoney et al.
Over the past three decades, the Hunt laboratory has developed advancements in mass spectrometry-based technologies to enable the identification of peptides bound to major histocompatibility complex (MHC) molecules. The MHC class I processi...
Utilizing a Negative Enrichment Strategy to Profile Protein Methylation, Leveraging the Orthogonality of LysargiNase and Trypsin [0.03%]
利用赖氨肽酶和胰蛋白酶正交性的去稳定富集策略用于蛋白质甲基化谱分析研究
Mingwei Sun,Shuxian Wei,Yang Li et al.
Mingwei Sun et al.
Protein methylation, a prevalent post-translational modification, plays crucial roles in chromatin remodeling and gene transcription. A deeper understanding protein methylation in these biological processes requires comprehensive characteri...
Proteome-wide Investigation of Proline Hydroxylation in Pancreatic Ductal Adenocarcinoma Using DiLeu Isobaric Labeling Strategy [0.03%]
基于DiLeu同位素标记策略的胰腺导管腺癌脯氨酸羟化蛋白质组研究
Feixuan Wu,Dylan Nicholas Tabang,Danqing Wang et al.
Feixuan Wu et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by a dense fibrotic stroma intertwined with a collagen-rich extracellular matrix (ECM), which significantly contributes to tumor progression. In this st...