Distinct proteomic and glycosylation signatures differentiate A549 tumor and BEAS-2B non-tumor cell line derived small extracellular vesicles [0.03%]
不同的蛋白质组和糖基化谱型区分A549肿瘤细胞系和BEAS-2B非瘤细胞系来源的小细胞外囊泡
Mirjam Balbisi,Tamás Langó,Virág Nikolett Horváth et al.
Mirjam Balbisi et al.
Extracellular vesicles (EVs) are central to intercellular communication and have gained attention as rich sources of molecular information in cancer research, but their molecular composition remains incompletely characterized. Protein glyco...
MsTargetPeaker: a quality-aware deep reinforcement learning approach for peak identification in targeted proteomics [0.03%]
基于质量感知的深度强化学习在靶向蛋白质组学顶峰识别中的应用：MsTargetPeaker方法及其评估
Chi Yang,Yung-Chin Hsiao,Chi-Ching Lee et al.
Chi Yang et al.
Targeted mass spectrometry enables precise peptide quantification by identifying high-quality chromatographic peaks for area integration. Automated peak identification remains challenging, particularly for low-abundance targets, due to inte...
High-throughput proteomic profiling to evaluate differentiation syndrome with menin inhibition [0.03%]
高通量蛋白质组学谱分析评估Menin抑制引起的分化综合征
Miriam B Garcia,Bofei Wang,Irtiza Sheikh et al.
Miriam B Garcia et al.
High-throughput proteomic profiling provides a comprehensive analysis of systemic cancer effects and tumor microenvironment interactions. Characterizing soluble proteins driving inflammation in acute myeloid leukemia (AML) offers insight in...
Recent advances in proximity labeling-based subcellular proteomic mapping [0.03%]
基于邻近标记的亚细胞蛋白质组学定位最新研究进展
Gang Wang,Jiapeng Liu,Xuege Sun et al.
Gang Wang et al.
The spatial organization of the cellular proteome is vital for cellular physiology, as protein localization is closely linked to post-translational modifications, subcellular trafficking, and protein-protein interactions. Systematic profili...
Ethylene-enhanced latex proteome is involved in stimulation of Natural Rubber Production in the Hevea Rubber Tree [0.03%]
乙烯增强的巴西橡胶树乳胶蛋白组参与天然橡胶生物合成的调控
Lixia He,Junjun Ma,Boxuan Yuan et al.
Lixia He et al.
The Hevea brasiliensis is the only commercial source of natural rubber. In natural rubber production, exogenous ethylene is widely used as a stimulant for increasing rubber latex yield. To reveal the potential regulation mechanisms for ethy...
Juliana Kikumoto Dias,Prabavi Shayana Dias,Rakhat Alakenova et al.
Juliana Kikumoto Dias et al.
Interchanging canonical histone H2A with variant H2A.Z in chromatin complexes is vital for the proper regulation of transcription, DNA damage repair, and centromere maintenance. However, the physical mechanisms underlying functional differe...
Nano-scaled, fully automated hydrogen/deuterium exchange for analysis of macromolecular assemblies reaching the MDa scale [0.03%]
纳米级全自动化氢/氘交换用于兆 Dalton 级大分子复合物的分析
Shaunak Raval,Yuqi Shi,Julia W Morriss et al.
Shaunak Raval et al.
Hydrogen/deuterium exchange mass spectrometry (HDX-MS) has become an indispensable tool for structural biology, yet conventional microflow configurations limit its application to readily expressible proteins available in microgram quantitie...
Deciphering stiffness-driven changes in colorectal cancer by proteomics [0.03%]
通过蛋白质组学解读结直肠癌中由硬度驱动的变化
Charlotte Cresens,Ana Montero-Calle,Guillermo Solís-Fernández et al.
Charlotte Cresens et al.
Tumor stiffening plays a pivotal role in cancer progression. Increased tumor stiffness, resulting from interactions between cancer cells and their surrounding microenvironment, alters the tumor's mechanical properties and significantly impa...
Multi-Omics Profiling Reveals Distinct Immunosuppression and Metabolic Dysregulation in Aggressive Subtypes of Thyroid Cancer [0.03%]
多组学谱分析揭示了甲状腺癌侵袭亚型的免疫抑制和代谢失调特征
Shanying Gui,Kate Huang,Jianling Qiang et al.
Shanying Gui et al.
Thyroid cancer comprises a heterogeneous group of malignancies with distinct clinical outcomes and molecular features, including papillary thyroid carcinoma (PTC), poorly differentiated thyroid carcinoma (PDTC), and anaplastic thyroid carci...
LIN28A-Dependent Kinome and Phosphoproteome Reprogramming Promotes Imatinib Resistance [0.03%]
LIN28A依赖的激酶组和磷酸化蛋白质组的重新编程促进伊马替尼耐药性
Owen F J Hovey,Mallory I Frederick,Quan M Quach et al.
Owen F J Hovey et al.
Chronic myeloid leukemia (CML) resistance to BCR-ABL tyrosine kinase inhibitors (TKIs) can arise from ABL kinase domain mutations, BCR-ABL fusion gene amplification, or kinase-independent mechanisms. To investigate imatinib-resistance, we p...