Actn4 links inactive Integrin α5 with actin in zebrafish somites [0.03%]
Actn4将斑马鱼躯体中的非活性整合素α5与肌动蛋白相连
Guangyu Sun,Scott A Holley
Guangyu Sun
Integrins are key plasma membrane proteins mediating cell-ECM adhesion and communication and rely on a conformational change for their activation and bidirectional signaling. However, there are few in vivo studies of integrin activation. He...
Charles C Mundorff,Sarah Hadley,Lisa M Tuttle et al.
Charles C Mundorff et al.
A longstanding limitation of Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) has been the difficulty to accurately measure amide exchange with single amide resolution. Excitation of peptides or proteins either during ionization, ion ...
Whole blood proteome dynamics defines predictive diagnostic and prognostic signatures of cryptococcal infection [0.03%]
全血蛋白组动力学定义了隐球菌感染的预测性诊断和预后标志物
Michael Woods,Jason A McAlister,Lauren Segeren et al.
Michael Woods et al.
Across the globe, fungi are impacting the lives of millions of people through the development of infections ranging from superficial to systemic with limited treatment options. To effectively combat fungal disease, rapid and reliable diagno...
Comparative N-Glycoproteomics Reveals Subtype-Specific N-Glycosylation Signatures and Immune Associations in Cholangiocarcinoma [0.03%]
比较N-糖蛋白组学揭示肝内胆管癌的亚型特异性N-糖基化标志物及其与免疫的关系
Zhili Xia,Li Gao,Meng Hu et al.
Zhili Xia et al.
Cholangiocarcinoma (CCA) comprises intrahepatic (iCCA) and extrahepatic (eCCA) subtypes, each exhibiting distinct molecular characteristics. Understanding these differences is critical for identifying subtype-specific therapeutic targets an...
Proteomic analysis of human topoisomerases reveals their distinct and diverse cellular functions [0.03%]
人类拓扑异构酶的蛋白质组分析揭示了它们独特的和多样的细胞功能
Huimin Zhang,Yun Xiong,Zhen Chen et al.
Huimin Zhang et al.
Topoisomerases are essential for resolving topological stress in DNA during key cellular processes. In human cells, six topoisomerases perform specialized yet overlapping functions to manage these challenges. To investigate their distinct a...
Proteogenomic Reassessment Provides Novel Insight into the Life Cycle of Tetrahymena thermophila [0.03%]
蛋白质组学再评估为 Tetrahymena thermophila 生活周期提供了新颖见解
Chen Gu,Mingkun Yang,Jing Zhang et al.
Chen Gu et al.
Tetrahymena thermophila (T. thermophila), a well-established model organism, has been instrumental in advancing our understanding of evolutionarily conserved biological processes. A key biological feature of this unicellular eukaryote is it...
Breaking Boundaries in Histone Modification MS-based Detection: A Tailored Search Strategy for Unrestricted identification of novel epigenetic marks [0.03%]
基于组蛋白修饰质谱的突破性边界检测：用于不受限制地鉴定新型表观遗传标志的定制化搜索策略
Alessandro Vai,Roberta Noberini,Andrea Graziadei et al.
Alessandro Vai et al.
Histone post-translational modifications (PTMs) play a crucial role in regulating gene expression and maintaining DNA integrity, and their aberrations are linked to various diseases, including cancer. While lysine acetylation and methylatio...
Proteomic portrait of degranulation program in human circulating neutrophils upon multi-inflammatory and infectious activation [0.03%]
人类循环中性粒细胞的多炎症和感染活化脱颗粒程序的蛋白质组特征描绘
Ying Hua,Ziqi Zhou,Can Zhang et al.
Ying Hua et al.
Neutrophils respond rapidly to inflammation and infection via defense mechanisms, including degranulation, reactive oxygen species (ROS) production, and neutrophil extracellular trap (NET) formation (known as 'NETosis'). As the most abundan...
High accuracy stool biomarkers of pre-cancerous colorectal cancer identified using a 2000-plex immunoproteomic screen [0.03%]
基于2000重免疫蛋白质组筛查的结直肠癌前病变高精度粪便生物标志物识别研究
Kamala Vanarsa,Jessica Castillo,Hao Li et al.
Kamala Vanarsa et al.
Background: Given the morbidity and mortality associated with colorectal cancer, novel biomarkers are clearly warranted, especially for early detection METHOD: An antibody-based screen of 2000 proteins was utilized to ide...
Zscan4 as a candidate conveyor of early developmental defects in O-GlcNAc transferase intellectual disability [0.03%]
O-连接N-乙酰氨基葡萄糖转移酶智能残疾的候选传导因子Zscan4在早期发育缺陷中的作用
Veronica M Pravata,Hao Jiang,Andrew T Ferenbach et al.
Veronica M Pravata et al.
Variants in the human β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) gene give rise to an intellectual disability (ID) syndrome termed OGT congenital disorder of glycosylation (OGT-CDG). The mechanisms by which loss of OGT and/or prote...