Restrained Wnt signaling pathway by enha nced EsGSK3β activity facilitates the infection of Spiroplasma and leads to neuropathic diseases in crustaceans [0.03%]
由EsGSK3β活性增强引起的Wnt信号通路受抑促进Spiroplasma感染并导致甲壳动物神经性疾病的发展
Libo Hou,Yu Yao,Yubo Ma et al.
Libo Hou et al.
Spiroplasma eriocheiris, has been identified as a lethal pathogen of Eriocheir sinensis tremor disease (TD), one neurological disease with typically paroxysmal tremors of the pereiopod. But the pathogenic mechanism of TD was still few known...
Jolkinolide B Activates Mitophagy to Exhibit Anti-pancreatic Cancer Activity and Alleviate Cognitive Deficits in Alzheimer's Disease [0.03%]
姜黄素类似物Jolkinolide B通过激活线粒体自噬发挥抗胰腺癌及改善阿尔茨海默病认知缺陷的作用
Mingjie Gao,Weiyi Hu,Delan Meng et al.
Mingjie Gao et al.
Dysfunctional mitophagy leads to the pathological accumulation of damaged mitochondria, which is closely associated with the development of human diseases such as cancer and Alzheimer's disease. The identification of safer and more effectiv...
Turning waste into insight: a novel proteomic approach to non-invasive wound biomarker discovery [0.03%]
变废为宝:一种新的蛋白质组学方法用于非侵入性伤口生物标志物的发现
Victoria Soto,Veronika Jurczuk,Lilian Valadares Tose et al.
Victoria Soto et al.
Chronic wounds such as diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) are a growing public health burden, contributing to significant morbidity, healthcare costs, and mortality. Current management strategies are hampered by the in...
Proteomic Insight into the Ontogeny of Blood-Meal Digestion in the tick Ixodes ricinus [0.03%]
蛋白质组学视角下的硬皮Ixodes ricinus幼虫期血餐消化研究
Tereza Kozelková,Martin Horn,Daniel Sojka et al.
Tereza Kozelková et al.
Ticks are important ectoparasites and vectors of variety of pathogens in both animals and humans, and their increasing global distribution poses a growing health risk. Unlike other blood-feeding vectors, ticks feed for an extended period of...
AlphaCross-XL: a seamless tool for automated and proteome-scale mapping of crosslinked peptides onto three-dimensional protein structures [0.03%]
AlphaCross-XL:一种用于自动且在蛋白质组范围内将交联肽绘制到三维蛋白质结构中的无缝工具
Sanjyot Vinayak Shenoy,Deeptarup Biswas,Arthur Zalevsky et al.
Sanjyot Vinayak Shenoy et al.
Crosslinking mass spectrometry (XL-MS) is an exciting proteomics technology to capture native protein conformations in real time within biological systems. Historically, however, implementation of this technology has typically been limited ...
Proteomic characterization of the Alzheimer's disease risk factor BIN1 interactome [0.03%]
阿尔茨海默病风险因子BIN1蛋白互作组的蛋白质谱分析
Joseph D McMillan,Shuai Wang,Jessica Wohlfahrt et al.
Joseph D McMillan et al.
The gene BIN1 is the second-largest genetic risk factor for late-onset Alzheimer's disease (LOAD). It is expressed in neurons and glia in the brain as cell-type-specific and ubiquitous isoforms. BIN1 is an adaptor protein that regulates mem...
Global proteomics reveals distinct muscle adaptations to menstrual cycle phase-based sprint interval training in endurance-trained females [0.03%]
基于月经周期的间歇训练对耐力运动员骨骼肌重塑的影响及其机制研究
Julie Kissow,Kamine Julie Jacobsen,Søren Jessen et al.
Julie Kissow et al.
Advances in mass-spectrometry (MS)-based technologies have leveraged our understanding of protein-wide adaptations in human skeletal muscle in response to exercise. However, there is a lack of such data in females, particularly pertaining t...
Pedro H C Franco,Rilee Zeinert,Jakob Meier-Credo et al.
Pedro H C Franco et al.
Small proteins or microproteins, despite long being ignored, have important roles in the regulation of larger protein complexes, metabolic pathways and gene expression. However, these proteins remain underrepresented in proteomics studies d...
Laura Hoffmann,Eva-Maria Eckl,Marleen Bérouti et al.
Laura Hoffmann et al.
The 5'-3' exonuclease phospholipase D3 (PLD3) is a single-pass transmembrane protein undergoing sequential post-translational modifications (PTM) by N-glycosylation, AMPylation and proteolytic cleavage. The substrates of PLD3 5'-3' exonucle...
A novel hybrid high speed mass spectrometer allows rapid translation from biomarker candidates to targeted clinical tests using 15N labeled proteins [0.03%]
一种新型混合高速质谱仪能够使用15N标记的蛋白从生物标志物候选者快速转化为目标临床检测
Maria Wahle,Philip M Remes,Vincent Albrecht et al.
Maria Wahle et al.
Recent developments in affinity binder or mass spectrometry (MS)-based plasma proteomics are now producing panels of potential biomarker candidates for diagnosis or prognosis. However, clinical validation and implementation of these biomark...