Surface Proteomics of Cancer-Derived Extracellular Vesicles Reveals Universal Heat Shock Proteins and Cancer Signatures [0.03%]
癌症来源的细胞外囊泡表面蛋白质组学揭示了普遍存在的热休克蛋白和癌症标志物
Leyla Ayse Erozenci,Fenna Feenstra,Sander R Piersma et al.
Leyla Ayse Erozenci et al.
Extracellular vesicles (EVs) secreted by cancer cells are a valuable source of noninvasive biomarkers, as they are released into biofluids and reflect the molecular makeup of their cells of origin. To enable direct capture and detection of ...
Nicotinamide Mononucleotide Combined Glucose Counteracts Iron Overload-Induced Mitochondrial Dysfunction in Mice Under Hypobaric Hypoxia [0.03%]
尼克酰胺单核苷酸联合葡萄糖改善缺氧小鼠铁过载引起的线粒体功能障碍
Fancheng Tan,Xiaoyun Huang,Xiaoya Mao et al.
Fancheng Tan et al.
Extreme high-altitude environment poses severe threats to human health, underscoring the urgent need for effective, safe metabolic interventions. Here, we demonstrate that combined regimen of nicotinamide mononucleotide (NMN) and glucose at...
An Integrated Cardiac Microtissue Proteome Map Extends Therapeutic Remodeling by Nanovesicles [0.03%]
集成心脏微组织蛋白质组地图通过纳米囊泡扩展治疗重塑作用
Jonathan Lozano,Jarmon G Lees,Jonathon Cross et al.
Jonathan Lozano et al.
Human cardiac microtissues are a promising model to study cardiac biology and disease, but their application is constrained by therapeutic remodeling strategies and limited knowledge of their functional protein expression profiles. Here, we...
Proteomic Insights Into Human Induced Regulatory T Cells: The Role of LPXN and CD160 in Immune Suppression [0.03%]
人诱导调节性T细胞的蛋白质组学见解：LPXN和CD160在免疫抑制中的作用
Kedar Batkulwar,Syed Bilal Ahmad Andrabi,Roosa Kattelus et al.
Kedar Batkulwar et al.
Regulatory T cells (Treg) play a central role in maintaining immune homeostasis, and the implementation of in vitro induced Treg cells (iTreg) to control immune function has significant potential in clinical medicine. The clinical applicati...
Top-Down Sequencing of Intact Proteoforms Using the timsOmni Mass Spectrometer: Accurate Determination of Co-Occurring Histone Modifications [0.03%]
基于timsOmni四极杆轨道阱质谱仪的组蛋白完整型从上到下序列分析及共存翻译后修饰的精确鉴定
Francis Berthias,Nurgül Bilgin,Athanasios Smyrnakis et al.
Francis Berthias et al.
Deep characterization of intact proteoforms remains an analytical challenge in functional proteomics, particularly for heterogeneous multi-site post-translational modifications at distinct amino acid residues. Histones are among the most dy...
Dynamic Alterations of Site-Specific N-Glycoform and Plasma Proteasome Signatures Stratify Chemotherapy Benefit in Pancreatic Ductal Adenocarcinoma [0.03%]
化疗在胰腺导管腺癌中的疗效分层的位点特异性N-聚糖和血浆蛋白酶体特征的动态改变
Shanying Gui,Yaqiong Zhang,Tao Xia et al.
Shanying Gui et al.
Pancreatic ductal adenocarcinoma (PDAC) exhibits profound systemic remodeling during chemotherapy, yet how site-specific intact N-glycosylation in plasma is rewired by treatment remains largely undefined. Here, we perform an integrated plas...
A Scalable Low-Input Redox Proteomics Workflow Enables High-Throughput Analysis of Cysteine Oxidation in 96-Well Cell Cultures [0.03%]
一种可扩展的低输入量氧化还原蛋白质组学工作流程，能够对96孔细胞培养基中的半胱氨酸氧化进行高通量分析
Adam M Kabza,Rosey Chu,Jesse Trejo et al.
Adam M Kabza et al.
Reversible oxidation of cysteine residues (redox modifications) plays a crucial role in regulating protein function, signaling, and cellular homeostasis. These dynamic modifications act as molecular switches that transduce redox signals and...
N-Glycoproteomics Sample Preparation Using Commercially Available Cellulose Magnetic Particles [0.03%]
使用商用纤维素磁颗粒进行N-糖蛋白质组样品制备
Ken Hanzawa,Miki Tanaka-Okamoto,Matej Nemcic et al.
Ken Hanzawa et al.
Glycopeptide preparation is a critical step in bottom-up glycoproteomics. In this study, a robust method for N-glycopeptide preparation was developed using low-cost, commercially available magnetic particles. These particles function as a s...
Urinary Proteomics Enables Non-Invasive and Longitudinal Monitoring of Tumor Burden Dynamics and Early Recurrence in HCC [0.03%]
尿蛋白组学可实现非侵入性动态监测肝癌肿瘤负荷及早期复发
Xiaohua Xing,En Hu,Lei Song et al.
Xiaohua Xing et al.
Purpose: To develop a non-invasive, urine-based approach for dynamic monitoring of tumor burden and early detection of recurrence in hepatocellular carcinoma (HCC), addressing the limited sensitivity of conventional serum...
Urinary Proteomics Enables Non-Invasive and Longitudinal Monitoring of Tumor Burden Dynamics and Early Recurrence in HCC [0.03%]
尿蛋白组学实现对肝癌肿瘤负荷动态及早期复发的非侵入性纵向监测
Xiaohua Xing,En Hu,Lei Song et al.
Xiaohua Xing et al.
Purpose: To develop a non-invasive, urine-based approach for dynamic monitoring of tumor burden and early detection of recurrence in hepatocellular carcinoma (HCC), addressing the limited sensitivity of conventional serum...