Deciphering stiffness-driven changes in colorectal cancer by proteomics [0.03%]
通过蛋白质组学解读结直肠癌中由硬度驱动的变化
Charlotte Cresens,Ana Montero-Calle,Guillermo Solís-Fernández et al.
Charlotte Cresens et al.
Tumor stiffening plays a pivotal role in cancer progression. Increased tumor stiffness, resulting from interactions between cancer cells and their surrounding microenvironment, alters the tumor's mechanical properties and significantly impa...
Multi-Omics Profiling Reveals Distinct Immunosuppression and Metabolic Dysregulation in Aggressive Subtypes of Thyroid Cancer [0.03%]
多组学谱分析揭示了甲状腺癌侵袭亚型的免疫抑制和代谢失调特征
Shanying Gui,Kate Huang,Jianling Qiang et al.
Shanying Gui et al.
Thyroid cancer comprises a heterogeneous group of malignancies with distinct clinical outcomes and molecular features, including papillary thyroid carcinoma (PTC), poorly differentiated thyroid carcinoma (PDTC), and anaplastic thyroid carci...
LIN28A-Dependent Kinome and Phosphoproteome Reprogramming Promotes Imatinib Resistance [0.03%]
LIN28A依赖的激酶组和磷酸化蛋白质组的重新编程促进伊马替尼耐药性
Owen F J Hovey,Mallory I Frederick,Quan M Quach et al.
Owen F J Hovey et al.
Chronic myeloid leukemia (CML) resistance to BCR-ABL tyrosine kinase inhibitors (TKIs) can arise from ABL kinase domain mutations, BCR-ABL fusion gene amplification, or kinase-independent mechanisms. To investigate imatinib-resistance, we p...
Multi-omics analysis of arboviral capsids targets in mosquitoes reveals a pro-viral function of the chromatin-remodeling Brahma complex [0.03%]
多组学分析揭示节肢节病毒衣壳在蚊虫中的靶点及染色质重塑复合体Brahma的促病毒感染功能
Charlotte Flory,Sanamjeet Virdi,Marcel Schie et al.
Charlotte Flory et al.
In recent years, arboviral infections have surged dramatically due to the geographic expansion of Aedes and Culex mosquitoes, their main vector mosquitoes. Despite significant efforts to uncover arbovirus-host interactions and viral protein...
Infosomes as Inflammatory Mediators: Proteomic Profiling of Proteins Enriched in Inflammatory Extracellular Vesicles [0.03%]
炎症介质信息小体：富含于炎性细胞外囊泡的蛋白质组学分析
Semin Lee,Minjun Kim,Seungmin Lee et al.
Semin Lee et al.
Extracellular vesicles (EVs), including exosomes and microvesicles, act as transmitters of various biological signals through cell-cell communication. Although EVs derived from immune response cells have been partially studied, the characte...
An unbiased molecular characterisation of peripartum cardiomyopathy hearts identifies mast cell chymase as a new diagnostic candidate [0.03%]
围产期心肌病心脏的无偏分子特征鉴定出肥大细胞胰蛋白酶为新的诊断候选标志物
J F Mulvey,C Sailer,J S Achter et al.
J F Mulvey et al.
Background: Peripartum cardiomyopathy (PPCM) is a rare form of acute heart failure that develops in women towards the end of pregnancy or early postpartum. No effective, specific treatment for PPCM is available and heart ...
Temporal proteomic and phosphoproteomic profiling deciphers molecular dynamics of acute-to-chronic kidney disease after ischemia-reperfusion injury, with Dock2 emerging as a key regulator [0.03%]
急性缺血再灌注损伤后肾脏急性病转慢性病的蛋白质组和磷酸化蛋白质组动态分析发现Dock2是关键调节因子
Shaowu Zhang,Huasheng Luo,Miaotao Wei et al.
Shaowu Zhang et al.
Acute kidney injury (AKI), characterized by a rapid decline in renal function, has high mortality rates and frequently progresses to chronic kidney disease (CKD). A major contributor to AKI is ischemia-reperfusion injury (IRI). However, the...
Higher-Throughput Proteome Profiling Enabled by Parallelized Pre-Accumulation and Optimized Ion Processing in the Orbitrap Astral Zoom Mass Spectrometer [0.03%]
平行化预积累和优化离子处理的轨道四极杆Astrall Zoom质谱仪实现更高通量蛋白质组学分析
Ulises H Guzman,Martin Rykar,Ivo A Hendriks et al.
Ulises H Guzman et al.
High-throughput proteomics is critical for understanding biological processes, enabling large-scale studies such as biomarker discovery and systems biology. However, current mass spectrometry technologies face limitations in speed, sensitiv...
Multiplexed Data-Independent Acquisition (mDIA) to Profile Extracellular Vesicle Proteomes [0.03%]
用于分析外泌体蛋白质组的多重数据非依赖性采集(mDIA)技术
Yi-Kai Liu,Nathaniel Miller,Marco Hadisurya et al.
Yi-Kai Liu et al.
Extracellular vesicles (EVs) have gained increasing attention with their intriguing biological functions and their molecular cargoes serving as potential biomarkers for various diseases, including cancers. A relatively lower abundance of EV...
Circulating extracellular vesicle protein biomarkers for the early detection of high-grade serous ovarian cancer [0.03%]
用于高分级浆液性卵巢癌早期诊断的循环细胞外囊泡蛋白生物标志物
Sagar Rayamajhi,Jared Sipes,Bidii Ngala et al.
Sagar Rayamajhi et al.
Small extracellular vesicles (sEVs), lipid-bilayer delimited particles (50-200 nm) released by cells, are emerging as a promising class of liquid biopsy biomarkers for elusive cancers such as high-grade serous ovarian cancer (HGSOC). HGSOC ...