Nitric oxide-mediated S-nitrosylation of the energy sensor KIN10 regulates RNA splicing and gene expression in Arabidopsis [0.03%]
Yanyan Yi,Xiahe Huang,Wan Wang et al.
Yanyan Yi et al.
Nitric oxide (NO) is a crucial signaling molecule involved in various developmental processes and stress responses through post-translational protein modification and modulation of gene expression. Despite significant advances in understand...
Update and new implementation of the MIRAGE reporting guidelines for mass spectrometry experiments in glycoscience [0.03%]
糖科学中基于质量测定实验的MIRAGE报告标准的更新与新实施方法
Frederique Lisacek,William E Hackett,Morten Thaysen-Andersen et al.
Frederique Lisacek et al.
The MIRAGE (Minimum Information Required for A Glycomics Experiment) guidelines for mass spectrometry (MS) data were initially developed to standardize the reporting of instrumentation, data acquisition and analytical details of the MS-base...
Proteomic analysis of small extracellular vesicles from lymphatic affluents in developing premetastatic niche in melanoma [0.03%]
黑色素瘤发展前期转移微环境淋巴引流中外泌体蛋白质组分析
Shankar Suman,Liyi Geng,Wendy K Nevala et al.
Shankar Suman et al.
Melanoma is an aggressive form of skin cancer that often metastasizes through lymph nodes (LNs). Lymphatic small extracellular vesicles (sEVs) derived from melanoma play a crucial role in establishing a premetastatic niche (PMN) within the ...
Serum AGP-1-Lex glycoforms report on survivorship of patients with septic shock upon admission to intensive care unit [0.03%]
入重症监护室的感染性休克患者的血清AGP-1-Lex糖型与患者生存率有关
The Huong Chau,Sayantani Chatterjee,Liam Caulfield et al.
The Huong Chau et al.
Septic shock, the excessive immune response to pathogen infection, accounts globally for ∼20% of all deaths. Current methods to establish disease severity are unacceptably slow, unspecific and insensitive, hindering timely and effective tr...
The Mechanism of Histone Ubiquitylation by the ASB9-CUL5 Ubiquitin Ligase [0.03%]
ASB9-CUL5泛素连接酶的组蛋白泛素化修饰机制研究
Calvin P Lin,Nathan Lee,Francis X Alipranti et al.
Calvin P Lin et al.
The E3 ligase substrate receptor ankyrin and SOCS box protein 9 (ASB9) was shown to bind over 10 different proteins including metabolic enzymes such as creatine kinase, filament proteins such as vimentin, and histones. In previous work, we ...
Proteomics data imputation with a deep model that learns from many datasets [0.03%]
一种从多个数据集中学习的深度模型用于蛋白质组学数据插补
Lincoln Harris,William S Noble
Lincoln Harris
Missing values are a major challenge in the analysis of mass spectrometry proteomics data. Missing values hinder reproducibility, decrease statistical power for identifying differentially abundant proteins and make it challenging to analyze...
Bottom-up proteomics under acidic conditions using protease type XIII from Aspergillus saitoi [0.03%]
酸性条件下应用岛藤霉菌蛋白酶十三型的自下而上蛋白质组学研究
Ryota Tomioka,Ayana Tomioka,Kosuke Ogata et al.
Ryota Tomioka et al.
Bottom-up proteomics is a powerful technique for comprehensive analysis of proteins by proteolytic cleavage followed by liquid chromatography/tandem mass spectrometry to identify the resulting peptides. Trypsin is the gold-standard protease...
Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/CFS following exertion [0.03%]
基于时间变化的血浆蛋白质组谱景观揭示了慢性疲劳综合症患者运动后的不良反应机制
Arnaud Germain,Katherine A Glass,Melissa A Eckert et al.
Arnaud Germain et al.
The overarching symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is post-exertional malaise (PEM), an exacerbation of symptoms following physical or mental exertion. To investigate the molecular underpinnings of PEM, w...
Oral microbiome-derived proteins in brain extracellular vesicles circulate and tie to specific dysbiotic and neuropathological profiles in age-related dementias [0.03%]
与年龄相关的痴呆症中口腔微生物群衍生的蛋白质在大脑细胞外囊泡中循环并连接到特定失调和神经病理特征之间关系的研究
María Mulet,Jose Antonio Sánchez Milán,Cristina Lorca et al.
María Mulet et al.
The involvement of the oral microbiome (OM) in the pathophysiology of Alzheimer's disease (AD) and vascular dementia (VaD) has been recognized epidemiologically, but the molecular mechanisms remain elusive. In this study, we uncovered the p...
Omics and Multiomics-Based Diagnostics for Invasive Candidiasis: Toward Precision Medicine [0.03%]
基于组学和多组学的侵袭性念珠菌病诊断：迈向精准医学
Aida Pitarch,Víctor Arribas,Concha Gil
Aida Pitarch
Invasive candidiasis (IC) is a serious, life-threatening, and costly fungal infection if not diagnosed early and treated appropriately. However, this healthcare-associated mycosis caused by Candida spp. is difficult to diagnose because of i...