Integrated IP-MS and Optoproteomics Reveal Dynamic Remodeling of Protein Interaction Networks During NLRP3 Inflammasome Activation [0.03%]
整合IP-MS和Opto蛋白组学揭示NLRP3炎性小体活化过程中蛋白质相互作用网络的动态重塑
Yuehui Zhang,Kairong Zhang,Chaozhi Jin et al.
Yuehui Zhang et al.
NOD-like receptor family pyrin domain-containing 3 (NLRP3) is a key intracellular sensor that assembles inflammasome complexes to activate inflammatory caspases, yet the molecular composition and stimulus-dependent organization of the NLRP3...
Method evaluation of liquid biopsy proteomics for limited plasma volume [0.03%]
小样本量条件下液体活检蛋白质组学方法评估
Ryo Takahashi,Florian Prodinger,Akiko Matsui
Ryo Takahashi
One of the biggest challenges in plasma proteomics is to reduce the dynamic range of plasma proteins to capture the expression of low-abundance proteins. Although abundant protein depletion and proximity extension assay are widely used for ...
Improved peptide search for identification of SUMO and sequence-based modifications, in MaxSBM [0.03%]
改进的肽搜索算法，用于SUMO和基于序列修饰的鉴定(MaxSBM)
Caroline Lennartsson,Pelagia Kyriakidou,Michael Lund Nielsen et al.
Caroline Lennartsson et al.
Post-translational modifications, such as SUMOylation and ubiquitination, regulate key cellular processes by covalently attaching to lysine residues. While mass spectrometry allows site-specific identification of PTMs, most existing search ...
Proteomic Analysis on Human Islets Suggests Nucleocytoplasmic Transport as a Mechanism of PERK Attenuation Effects in Diabetes [0.03%]
蛋白组分析提示人类胰岛中PERK抑制作用的机制与核质转运有关
Yeon Soo Park,Soeun Yun,Min Seop Sim et al.
Yeon Soo Park et al.
Background: Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and gluco...
Adillah Gul,Laura Van Moortel,Patrick Willems et al.
Adillah Gul et al.
Mass spectrometry (MS)-based immunopeptidomics is a powerful approach for untargeted discovery of peptides presented on major histocompatibility complex (MHC) molecules, which can guide the selection of vaccine antigens and immunotherapy ta...
Multidimensional Proteomics Reveals the Pro-apoptotic Mechanism of Platycodin D: Targeting RFC4 to Regulate the Notch Signaling Axis in Non-Small Cell Lung Cancer [0.03%]
基于多维蛋白质组的半夏皂苷d抗非小细胞肺癌作用机制研究：下调RFC4抑制Notch信号通路介导的细胞凋亡
Hongyu Zhang,Baojin Zhou,Jingwen Liu et al.
Hongyu Zhang et al.
Background and aim: Platycodin D (PD), a major bioactive saponin isolated from the traditional Chinese medicine (TCM) Platycodon grandiflorus, has shown promising therapeutic potential against non-small cell lung cancer (...
Seyed Sadegh Eslami,Alin Rai,Haoyun Fang et al.
Seyed Sadegh Eslami et al.
Heart specialization involves nuclear programs however, chamber-specific regulation of the nuclear proteome landscape remains unknown. In this study we isolated the nucleus from four major anatomical regions of healthy mouse heart (fresh) a...
Jiangli Zhu,Wenchao Li,Mingyang Ji et al.
Jiangli Zhu et al.
ARF1 plays a crucial role in maintaining the structure and function of the Golgi apparatus, yet the precise on-site regulatory mechanism governing ARF1 activation remains incompletely understood. Here, we have uncovered a novel regulatory m...
A proteogenomic approach to discover novel lncRNA-derived microproteins and their potential clinical utility in hepatocellular carcinoma [0.03%]
肝细胞癌中发现新型长链非编码RNA衍生的微蛋白及其潜在临床应用的蛋白质基因组学方法
Bingwu Li,Kandarp Joshi,Dan Ohtan Wang
Bingwu Li
Microproteins (i.e., peptides) are increasingly recognized for their functions in versatile biological contexts but their clinical relevance and utility remain largely unexplored. Proteogenomic approaches can accelerate microprotein discove...
Correction: Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane [0.03%]
订正：定量蛋白组学链接LRRC59互作蛋白到内质网膜上的mrRNA翻译
Molly M Hannigan,Alyson M Hoffman,J Will Thompson et al.
Molly M Hannigan et al.