Epithelium-derived IL17A Promotes Cigarette Smoke-induced Inflammation and Mucus Hyperproduction [0.03%]
上皮细胞源性IL17A促进香烟烟雾诱导的炎症和黏液高分泌
Mindan Wu,Tianwen Lai,Du Jing et al.
Mindan Wu et al.
The airway epithelium is a central modulator of innate and adaptive immunity in the lung. IL17A expression was found to be increased in the airway epithelium; however, the role of epithelium-derived IL17A in chronic obstructive pulmonary di...
Decreased Cyclic Guanosine Monophosphate-Protein Kinase G Signaling Impairs Angiogenesis in a Lamb Model of Persistent Pulmonary Hypertension of the Newborn [0.03%]
一氧化氮-环磷酸鸟苷-蛋白激酶信号途径下调影响新生儿持续性肺动脉高压血管生成：绵羊模型研究
Megha Sharma,Ujala Rana,Chintamani Joshi et al.
Megha Sharma et al.
Impaired angiogenesis function in pulmonary artery endothelial cells (PAEC) contributes to persistent pulmonary hypertension of the newborn (PPHN). Decreased nitric oxide (NO) amounts in PPHN lead to impaired mitochondrial biogenesis and an...
Integrated 'Omics in Idiopathic Pulmonary Fibrosis: Where Do We Go from Here? [0.03%]
特发性肺纤维化中的整合“组学”：我们接下来的路在何方？
Peter J Castaldi
Peter J Castaldi
Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures [0.03%]
人呼吸道病毒诱导的肺组织反应模仿慢性阻塞性肺病和哮喘的基因特征
Sabine Wronski,Soren Beinke,Helena Obernolte et al.
Sabine Wronski et al.
Human rhinovirus (RV) is a major risk factor for chronic obstructive pulmonary disease (COPD) and asthma exacerbations. The exploration of RV pathogenesis has been hampered by a lack of disease-relevant model systems. We performed a detaile...
Smoking and Human Immunodeficiency Virus 1 Infection Promote Retention of CD8+ T Cells in the Airway Mucosa [0.03%]
吸烟和人类免疫缺陷病毒1型感染促进呼吸道粘膜中CD8+t细胞滞留
Björn Corleis,Josalyn L Cho,Samantha J Gates et al.
Björn Corleis et al.
Smoking and human immunodeficiency virus 1 (HIV-1) infection are risk factors for chronic obstructive pulmonary disease (COPD), which is among the most common comorbid conditions in people living with HIV-1. HIV-1 infection leads to persist...
Extracellular Vesicles: Progress and Challenges in the Study of Human Immunodeficiency Virus and Cocaine-associated Pulmonary Arterial Hypertension [0.03%]
细胞外囊泡：人类免疫缺陷病毒和可卡因相关肺动脉高压研究的进展与挑战
Camilla Margaroli,Derek Russell
Camilla Margaroli
Connecting COPD GWAS Genes: FAM13A Controls TGFβ2 Secretion by Modulating AP-3 Transport [0.03%]
FAM13A基因通过调节AP-3转运调控TGFβ2分泌连接COPD的GWAS基因
Lu Gong,Samuel Bates,Jian Li et al.
Lu Gong et al.
Chronic obstructive pulmonary disease (COPD) is a common, complex disease and a major cause of morbidity and mortality. Although multiple genetic determinants of COPD have been implicated by genome-wide association studies (GWASs), the path...
Martin Witzenrath,Wolfgang M Kuebler
Martin Witzenrath
Katrina E Traber,David M Center
Katrina E Traber