CCL18 with an Attitude: Unlocking the Role of Macrophage CCL18 in Checkpoint Inhibitor Pneumonitis [0.03%]
带有态度的CCL18：解锁巨噬细胞CCL18在检查点抑制剂肺炎中的作用
Nathanial J Tolman,William Bain
Nathanial J Tolman
Urokinase Plasminogen Activator Receptor Attenuates Allergen-induced Eosinophil Migration and Airway Hyperresponsiveness [0.03%]
尿激酶型纤溶酶原激活物受体削弱过敏诱导的嗜酸性粒细胞迁移和气道高反应性
Gregory S Whitehead,Keiko Nakano,Christina L Wilkinson et al.
Gregory S Whitehead et al.
Allergic asthma is a widespread disease of the airway stemming from the actions of multiple cell types, including eosinophils and epithelial cells. The urokinase plasminogen activator receptor (uPAR) is a membrane bound protein that can con...
Sexually Distinct Multi-Omic Responses to Progressive Endurance Exercise Training in the Rat Lung - Findings from MoTrPAC [0.03%]
来自MoTrPAC的发现：大鼠肺部对渐进耐力锻炼训练产生性别特异性的多组学反应
Gina M Many,Tyler J Sagendorf,Hugh Mitchell et al.
Gina M Many et al.
Endurance exercise is broadly beneficial to cardiopulmonary function, with these benefits thought to be driven by extrapulmonary factors rather than direct structural changes in the lungs. Thus, to address how endurance exercise training an...
Pulmonary Blood Volumes on CT Predict Residual Pulmonary Hypertension Post-Pulmonary Endarterectomy [0.03%]
术前CT肺血流量评估肺动脉内膜剥脱术后肺动脉高压的复发价值
Hakim Ghani,Muhunthan Thillai,David Jenkins et al.
Hakim Ghani et al.
Pulmonary blood volumes (PBV), currently not assessed by computed tomography pulmonary angiography (CTPA), could provide additional information to routine investigations performed for chronic thromboembolic pulmonary hypertension (CTEPH). W...
Design and Characterization of 4D-710, an Aerosolized Gene Therapy for Cystic Fibrosis Lung Disease [0.03%]
4D-710的设计与表征，一种囊性纤维化肺病的吸入型基因疗法
Melissa A Calton,Roxanne H Croze,Theodore H Sullivan et al.
Melissa A Calton et al.
Cystic fibrosis (CF) is an autosomal recessive disease caused by variants in the gene encoding the CF transmembrane conductance regulator (CFTR) protein. Delivery of a functional CFTR transgene to airway epithelial cells (AEC) offers the po...
Specialized Pro-Resolving Mediator Loaded Extracellular Vesicles Mitigate Pulmonary Inflammation [0.03%]
特异化促进解决介质负载的细胞外囊泡可减轻肺部炎症
Manjula Karpurapu,Jiasheng Yan,Sangwoon Chung et al.
Manjula Karpurapu et al.
Extracellular vesicles (EVs) have emerged as versatile carriers of therapeutic cargo, including nucleic acids, proteins, and small molecules. However, their potential to deliver bioactive lipid mediators remains largely unexplored. Here, we...
Interleukin-7 Receptor Activation in Interstitial Macrophages Promotes Lung Fibrosis through Spp1 [0.03%]
间质巨噬细胞中白介素-7受体通过Spp1促进肺纤维化激活
Kohsuke Shirakawa,Motoaki Sano,Iwao Sakane et al.
Kohsuke Shirakawa et al.
Osteopontin, also known as secreted phosphoprotein 1 (Spp1), is a key molecule involved in lung fibrosis; however, the mechanism underlying the exacerbation caused by Spp1-producing cells remains unclear. In the present study, we investigat...