Altered cholesterol immunometabolism activates the macrophage NLRP3-inflammasome in lung fibrosis [0.03%]
胆固醇免疫代谢的改变可激活肺纤维化中巨噬细胞的NLRP3炎性小体
Mariza Vaso,Matija Dukic,Peter Pennitz et al.
Mariza Vaso et al.
Previous research has highlighted dysregulation in lipid metabolism during lung fibrosis. However, the impact of cholesterol immunometabolism during lung fibrosis progression remains unclear but has been related to the NLRP3-inflammasome ac...
Titrating cumulative neonatal hyperoxia in mice to model bronchopulmonary dysplasia severities [0.03%]
用于模拟支气管肺发育不良严重程度的小鼠累积性新生儿高氧滴定模型
Brooke Dir,Raveena Mishra,Nicole Hennen et al.
Brooke Dir et al.
The severity of bronchopulmonary dysplasia (BPD) is defined by the type or amount of respiratory support needed at 36 weeks postmenstrual age, reflecting varying degrees of impairment in the supply and demand systems regulating arterial oxy...
Airway Secretory Cells Contain Both a Perinuclear Golgi Ribbon and Dispersed Golgi Satellites [0.03%]
气道分泌细胞同时包含核周高尔基复合体 ribbon 和分散的 golgi 小体卫星结构
Oanh N Hoang,Colin E Chan,Joshua M Brenner et al.
Oanh N Hoang et al.
Rationale: Finely tuned production and secretion of the polymeric mucins MUC5AC and MUCB are required for lung health, but knowledge of many details between their translation and their packaging into secretory granules is...
A FGFR3 decoy receptor attenuates lung fibroblast-to-myofibroblast transition and pulmonary fibrosis [0.03%]
FGFR3 蛋白诱骗受体可抑制肺成纤维细胞向肌成纤维细胞转化及肺纤维化的发展
Célia Scribe,Diogo Gonçalves,Marine Gautier-Isola et al.
Célia Scribe et al.
Fibroblast growth factor (FGF) signaling plays an important role in the pathogenesis of various respiratory diseases, including idiopathic pulmonary fibrosis (IPF). FGF ligands can exert both pro- and anti-fibrotic effects, depending on the...
CD44 is critical for TLR4-mediated NLRP3 inflammasome activation and the development of BPD [0.03%]
CD44在TLR4介导的NLRP3炎性小体激活及BPD发病中的关键作用
Jie Liao,Christopher Longoria,C Vivek Lal et al.
Jie Liao et al.
Rationale: Bronchopulmonary Dysplasia is a chronic lung disease of preterm infants. We previously established the NLRP3 inflammasome as critical in the pathogenesis of BPD. The hyaluronan receptor CD44 interacts with TLR4...
Furin Inhibition Protects Against Acute Lung Injury in a Mouse Model of Pseudomonas Aeruginosa Infection [0.03%]
furin酶抑制剂对铜绿假单胞菌感染小鼠急性肺损伤的保护作用
Olivier Bernard,Michael Kwon,Mark R Looney et al.
Olivier Bernard et al.
Pseudomonas aeruginosa (PA) is responsible for significant morbidity and mortality particularly in patients with chronic lung diseases such as chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF) as well as hos...
MCT4 mediates hypoxia-induced extracellular lactate release from IPF fibroblasts [0.03%]
MCT4介导IPF成纤维细胞中的低氧诱导的细胞外乳酸释放
Richard S Nho,Lauren Nielsen,Jessica Roberts et al.
Richard S Nho et al.
Lactate is increased in the lungs of patients with Idiopathic Pulmonary Fibrosis (IPF) and in mice with experimental lung fibrosis, and lactate has been linked to the pathogenesis of lung fibrosis. IPF fibroblasts in hypoxic conditions gene...
Whole blood transcriptomics reveals sepsis mortality-associated changes in neutrophil degranulation [0.03%]
全血转录组学揭示了与脓毒症死亡相关的中性粒细胞脱颗粒变化
Heather M Giannini,Mengyuan Kan,Christopher V Cosgriff et al.
Heather M Giannini et al.
Transcriptomic analysis of blood cells can reveal key elements of the dysregulated host response in sepsis and spur biomarker and mechanism identification. We hypothesized that sepsis nonsurvivors exhibit a distinct transcriptional signatur...
Sarah E Holton,Carmen Mikacenic
Sarah E Holton
Yunfan Hu,Ying Wang,Changhao Ren et al.
Yunfan Hu et al.
The vacuolar H+-ATPase (V-ATPase) is an enzymatic complex responsible for pumping H + into the cytosol, thereby maintaining intracellular pH; however, its role in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is unclear...