Mansi Upadhyay,Destini Nelson,Mollie Phillips et al.
Mansi Upadhyay et al.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are heterogeneous and potentially fatal consequences of serious conditions such as trauma and sepsis, an exacerbated inflammatory response to infection. There are no eff...
Science Under Siege [0.03%]
饱受攻击的科学
Kelsey Hills-Dunlap,David A Schwartz
Kelsey Hills-Dunlap
Macrophage CCL18 Promotes Lung Inflammation in Checkpoint Inhibitor Pneumonitis [0.03%]
巨噬细胞CCL18促进免疫检查点抑制剂引起的肺炎症
Mohammad I Ghanbar,Andres Villabona-Rueda,Nicolas Philip et al.
Mohammad I Ghanbar et al.
Checkpoint inhibitor pneumonitis (CIP) is a highly morbid complication of immune checkpoint immunotherapy, characterized by acute lung injury leading, in severe cases, to hypoxic respiratory failure and death. CIP incidence in lung cancer i...
Integrated Longitudinal Transcriptomic and Proteomic Analysis of the Murine Lung Response to Influenza A Virus [0.03%]
流感病毒小鼠肺部纵向转录组和蛋白质组联合分析
Tim Flerlage,David F Boyd,Brandi Clark et al.
Tim Flerlage et al.
Lung injury caused by influenza is a leading cause of respiratory infection-related morbidity and mortality worldwide. In its severe form, influenza can cause acute respiratory distress syndrome (ARDS), which manifests as severe hypoxemic r...
Alteration of OxPLs Profile in BAL Collected from Atopic Individuals Co-Exposed to Air Pollution and Allergen [0.03%]
空气污染和过敏原共暴露对特应性个体肺泡灌洗液中氧化型磷脂的影响研究
Angela A Zhang,Min Hyung Ryu,Aruni Jha et al.
Angela A Zhang et al.
Weiqiang Kong,Chunli Huang,Lu Zhao et al.
Weiqiang Kong et al.
A subset of severe asthma is characterized by neutrophilic airway inflammation in which epithelial activation of the NLRP3 inflammasome pathway is implicated. Recent reports link SERPINB10 to neutrophil activation in inflammatory disease. W...
Anti-vimentin Antibody Mitigates SARS-CoV-2 Spike Protein-induced Fibroblast Activation and Fibrosis [0.03%]
抗vimentin抗体缓解SARS-CoV-2刺突蛋白诱导的纤维母细胞活化和纤维化
Łukasz Suprewicz,Alicja Walewska,Paulina Paprocka et al.
Łukasz Suprewicz et al.
SART3 Activates CD36 Transcription by Recruiting FOXM1 and Activates PARP to Augment Cisplatin Resistance in Non-Small Cell Lung Cancer [0.03%]
SART3通过募集FOXM1增强CD36转录并激活PARP以增加非小细胞肺癌的顺铂耐药性
Wenhui Huang,Bin Bi,Qilan Huang et al.
Wenhui Huang et al.
Cisplatin resistance remains a major barrier to effective lung cancer treatment. In this study, we identified that SART3 is upregulated in cisplatin-resistant non-small cell lung cancer (NSCLC) cells and promotes DNA damage repair. SART3 de...
Lung CD14dimCD16high Nonclassical Monocytes Are Associated with Systemic Inflammation and Cardiovascular Disease Risk in COPD [0.03%]
肺部CD14dimCD16high非经典单核细胞与慢性阻塞性肺疾病系统性炎症和心血管疾病风险的相关性
Takuya Saito,Naoya Fujino,Shuichi Konno et al.
Takuya Saito et al.
Single Cell Omics Identify an Anti-Inflammatory Niche in Macrophages of Mild to Moderate COPD [0.03%]
单细胞组学识别出轻至中度慢阻肺巨噬细胞中的抗炎生态位
Baihui Lv,Mengmeng Jiang,Guofei Zhang et al.
Baihui Lv et al.
Chronic obstructive pulmonary disease (COPD) is a major contributor to global mortality rates, yet the cell-specific mechanisms underlying its pathobiology remain poorly understood, particularly in mild disease stages. Single-cell profiles ...