The Role of The Surgical Pathologist in the Recognition of Hereditary Gynecologic Cancer [0.03%]
病理学家在识别遗传性妇科癌症中的作用
Fabiola Medeiros,Jennifer A Bennett
Fabiola Medeiros
A wide spectrum of tumors can affect the gynecologic tract in the context of hereditary cancer syndromes. Over the past two decades, the approach to germline testing initiated by pathologic findings has evolved considerably. This shift bega...
Part 1: The Role of the Surgical Pathologist in the Recognition of Hereditary Tumor Syndromes [0.03%]
第一部分：外科病理学家在识别遗传性肿瘤综合征中的作用
Vania Nosé,Abbas Agaimy,Zubair Baloch et al.
Vania Nosé et al.
Gerald J Berry,Thomas K Watkins,Steven J Ruoss
Gerald J Berry
The perivascular epithelioid cell family of neoplasms in the lung encompass lymphangioleiomyomatosis, angiomyolipoma, angioleiomyoma, and perivascular epithelioid cell tumor (PEComa). They share the unique attribute of immunoreactivity for ...
Maria S Tretiakova
Maria S Tretiakova
MiT/TFE family of transcription factors, including MiTF, TFE3, TFEB, and TFEC genes, control transcriptional programs for autophagy and lysosome biogenesis and regulate energy metabolism in many cancers. Chromosomal translocations and ampli...
Diagnosis and Reporting of Intraductal Carcinoma of the Prostate: A Guide for Practising Pathologists With Excerpts From the Genitourinary Pathology Society and the International Society of Urological Pathology Joint Expert Consultation [0.03%]
前列腺导管内癌的诊断与报告：实用病理学家指南及泌尿系统病理学会和国际泌尿病理学协会联合专家咨询会意见摘录
Rajal B Shah,Murali Varma,Ming Zhou et al.
Rajal B Shah et al.
Atypical intraductal proliferations of the prostate span a spectrum from high-grade prostatic intraepithelial neoplasm (HGPIN) to intraductal carcinoma of the prostate (IDCP), with progressively more atypical architectural and cytologic fea...
Benjamin L Coiner,William J Anderson
Benjamin L Coiner
Paratesticular soft tissue tumors are infrequently encountered in surgical pathology and can often pose diagnostic challenges. A wide range of mesenchymal neoplasms may arise in this region, encompassing entities that vary significantly wit...
Recognizing Familial Thyroid Neoplasia: The Pathologist's Role in Diagnosis and Management [0.03%]
认识家族性甲状腺肿瘤：病理学家在诊断和治疗中的作用
Vania Nosé,Sule Canberk,Zubair Baloch
Vania Nosé
Thyroid carcinoma is the most common endocrine malignancy, with papillary thyroid carcinoma (PTC) comprising most cases and arising from follicular epithelial cells. Although most follicular cell-derived thyroid carcinomas are sporadic and ...
Hereditary and Familial Tumor Syndromes: When to Think of Them? The Emerging Role of Pathologists as Sentinels of Genetic Cancer Predisposition [0.03%]
遗传性和家族性肿瘤综合征：何时考虑它们？病理学家在遗传性癌症易感性哨兵中的作用日益重要
Vania Nosé,Sule Canberk,Abbas Agaimy
Vania Nosé
Germline predisposition contributes to at least 10% of human malignancies and is identified in ∼8.5% to 10% of pediatric cancers, with notably higher frequencies in specific tumor types, including over 60% in adrenocortical carcinoma and 1...
From Familial Clustering to a Dedicated Classification: The Historical Recognition of Hereditary Tumor Syndromes in the WHO Classification of Tumors [0.03%]
从家族聚集到专门分类世界卫生组织肿瘤分类中遗传性肿瘤综合征的历史性承认
Sule Canberk,Vania Nosé
Sule Canberk
Background: Familial cancer aggregation has been recognized for more than 150 years. For much of that period, hereditary tumor predisposition was incorporated into tumor classification in a fragmented, organ-specific mann...
The Role of the Surgical Pathologist in the Recognition of Hereditary SDH-Deficient Tumor Syndromes [0.03%]
手术病理学家在识别SDH缺陷型遗传性肿瘤综合征中的作用
C Christofer Juhlin,Ozgur Mete
C Christofer Juhlin
Succinate dehydrogenase (SDH)-deficient tumors form an expanding, clinically important group of neoplasms driven by disruption of mitochondrial complex II through germline or somatic alterations in SDHA-D or SDHAF2, or by epigenetic silenci...