Multi-Omics Profiling Identifies HMGA2 Fusions as Defining a Distinct and Prognostically Favorable Subtype of Dedifferentiated Liposarcoma with Rhabdomyosarcomatous Differentiation [0.03%]
多组学谱分析识别HMGA2融合基因可定义具有横纹肌肉瘤分化的去分化脂肪肉瘤独特且预后良好的亚型
Xinke Zhang,Xiujiao Shen,Ping Chen et al.
Xinke Zhang et al.
Dedifferentiated liposarcoma (DDLPS) with rhabdomyosarcomatous differentiation is associated with a poorer prognosis compared to other DDLPS subtypes. This highlights the importance of exploring its clinicopathological, immune microenvironm...
Practical approaches to the diagnosis and differential diagnosis of T-lymphoblastic leukemia/lymphoma [0.03%]
T淋巴母细胞白血病/淋巴瘤诊断及鉴别诊断的临床思路
Wei J Wang,Joseph D Khoury,Hong Fang et al.
Wei J Wang et al.
T-lymphoblastic leukemia/lymphoma is a malignant neoplasm derived from T-cell precursors. These neoplasms can present initially as acute lymphoblastic leukemia (ALL) involving bone marrow or lymphoblastic lymphoma (LBL) involving lymph node...
Contemporary approach to diagnosis and classification of acute myeloid leukemia [0.03%]
急性髓系白血病的诊断和分类的当代方法
Derek M Loneman,Valentina Nardi,Robert P Hasserjian
Derek M Loneman
The term acute myeloid leukemia (AML) refers to a group of myeloid neoplasms characterized by maturation arrest, classically defined as ≥20% myeloblasts or myeloblast equivalents in the peripheral blood or bone marrow. In recent decades, a...
Metastatic Malignant Non-Cervical Gynecological Tumors Involving the Genitourinary System: A Contemporary Clinicopathologic Analysis of 27 Patients [0.03%]
近27例妇科恶性肿瘤泌尿系统转移的临床病理学分析
Yulin Haw,Adeboye O Osunkoya
Yulin Haw
Introduction: Metastatic non-cervical gynecological tumors involving the genitourinary system have not been well characterized. Materials and methods: ...
Thymic hyperplasia with lymphoepithelial sialadenitis-like features A single-institution series of 21 new cases [0.03%]
以淋巴上皮性腮腺炎为特征的胸腺增生：21例单中心病例报告系列研究
Annikka Weissferdt,L Jeffrey Medeiros,Cesar A Moran
Annikka Weissferdt
Thymic hyperplasia with lymphoepithelial sialadenitis-like features (TH-LESA) is a rare tumor-like condition of the thymic gland with less than 50 cases reported in the literature. Named after its resemblance to lymphoepithelial sialadeniti...
Clinicopathological significance of methylthioadenosine phosphorylase (MTAP) expression loss in hepatobiliary tumors [0.03%]
甲基硫腺苷磷酸化酶(MTAP)表达缺失在肝胆肿瘤中的临床病理意义分析
Motoko Sasaki,Yasunori Sato,Yasuni Nakanuma
Motoko Sasaki
Backgrounds: Expression loss of methylthioadenosine phosphorylase (MTAP), a tumor suppressor gene often co-deleted with CDKN2A/B, is a useful diagnostic marker of malignant tumors, such as mesothelioma, and a potential th...
Radiological over- and underestimation of DCIS extent in breast conserving surgery specimens: radiological-pathological correlation in slice radiographs and respective histological large-format slides [0.03%]
乳腺保守手术标本中DCIS范围的放射学过度和低估：切片放射摄影与相应的大格式组织学幻灯片的放射学-病理学相关性
Bartosz Radzinski,Teresa Loebsin,Paul J van Diest et al.
Bartosz Radzinski et al.
Purpose: Disease extent is an independent risk factor for local recurrence in ductal carcinoma in situ (DCIS) of the breast. Surgical strategies mainly depend on area size of microcalcifications in mammograms which, howev...
The role of advanced molecular diagnostics in informing targeted therapies for AML [0.03%]
高级分子诊断在指导急性髓系白血病精准治疗中的作用
Jennifer Marvin-Peek,Sanam Loghavi,Ghayas C Issa et al.
Jennifer Marvin-Peek et al.
The application of advanced molecular diagnostics has transformed the clinical management of patients with acute myeloid leukemia (AML), a heterogeneous disease characterized by a diverse genomic landscape. Comprehensive molecular profiling...
Guilin Tang,Qing Wei,Melanie Klausner et al.
Guilin Tang et al.
We summarize the technical principles of optical genome mapping (OGM) and evaluate its current clinical applications across myeloid neoplasms, with emphasis on acute myeloid leukemia and myelodysplastic syndromes. We highlight evidence demo...
Multimodal measurable residual disease detection in acute myeloid leukemia: From technology to clinical integration [0.03%]
急性髓系白血病的多模态可测量残留疾病检测：从技术到临床整合
George Mason,Ameya Hanamshet,Jad Othman
George Mason
Measurable residual disease (MRD) is an increasingly vital tool in predicting the risk of relapse in patients with acute myeloid leukemia (AML), with a growing role in directing therapeutic choices. The vast phenotypic and genomic heterogen...