Correlation Analysis of TP53 Missense Mutations and p53 Protein Expression Patterns in Endometrial Carcinoma [0.03%]
子宫内膜癌中TP53错义突变与p53蛋白表达模式的相关性分析
Ying Yang,Shu Sun,Yun Xi et al.
Ying Yang et al.
p53 abnormality (p53 abn) subtype is a critical category in endometrial carcinoma (EC) molecular classification, yet clinical diagnosis often relies solely on p53 immunohistochemistry (IHC) staining or TP53 gene sequencing. This study aimed...
Discovery and Clinical Significance of 1p36 Chromosomal Aberrations in Differentiating Hepatocellular Carcinoma from Other Hepatobiliary Cancers [0.03%]
鉴别肝细胞癌与其它胆道恶性肿瘤的1p36染色体异常的发现及其临床意义
Wantakan Ngamsangiam,Sutheemon Techa-Ay,Prakasit Sa-Ngiamwibool et al.
Wantakan Ngamsangiam et al.
Differentiating among hepato-pancreato-biliary (HPB) cancers like cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC), pancreatic cancer (PC), and gallbladder cancer (GBC) can be challenging. To address this, our study used fluorescenc...
Acute Leukemia with BCL11B Rearrangements: Genetic Landscape, BCL11B Expression, and Therapeutic Response [0.03%]
携带BCL11B重排的急性白血病的遗传图谱、BCL11B表达及治疗反应
Guilin Tang,Sa A Wang,Wei Ying Jen et al.
Guilin Tang et al.
Rearrangements involving BCL11B have emerged as important structural variants in acute leukemias with T lineage differentiation, yet their prevalence and biological significance remain incompletely defined. Using optical genome mapping (OGM...
Polymorphic central nervous system (CNS) immune deficiency/dysregulation-associated lymphoproliferative disorders show a uniquely aggressive clinicopathologic profile compared to their extra-CNS counterparts [0.03%]
与中枢神经系统外 counterpart相比，多态性中枢神经系统（CNS）免疫缺陷/失调相关淋巴增值性疾病具有独特的临床病理特征
Frank Rojas Alvarez,Eric I Nayman,Yi-Hua Chen et al.
Frank Rojas Alvarez et al.
Background: Primary central nervous system immunodeficiency/dysregulation-associated lymphoproliferative disorders (PCNS-IDD-LPDs) are a rare and heterogeneous group of lymphoid lesions that arise within the CNS of immune...
Morphologic and Immunohistochemical Study of HPV-Related Cervical Adenosquamous Carcinoma: Reappraisal of a Poorly Defined Entity [0.03%]
HPV相关宫颈腺鳞癌的形态学和免疫组化研究：一种定义不清类型的再评价
Zhenwei Zhang,M Ruhul Quddus,C James Sung et al.
Zhenwei Zhang et al.
Objective: Current WHO criteria require distinct glandular and squamous differentiation for diagnosis of adenosquamous carcinoma (AdSq). However, a subset of poorly differentiated cervical carcinoma exhibits ambiguous mor...
Epstein-Barr Virus Associated Gastric Carcinoma: A Clinicopathologic Study with Recognition of a Distinctive Reticular Histologic Pattern [0.03%]
与EB病毒相关的胃癌：临床病理学研究及识别独特的网状组织学模式
Julia Gallardo,Emrah Gumusgoz,James Mitchell et al.
Julia Gallardo et al.
Existing data characterize "classic" Epstein-Barr virus (EBV) positive gastric carcinoma (GC) histologically as GC with lymphoid stroma (or lymphoepithelioma-like or medullary) exhibiting sheets or syncytia of malignant cells with prominent...
Prostatic Adenocarcinoma Identified on Transurethral Resection of Bladder Tumor: A Clinicopathologic Series of a Diagnostically Relevant Potential Pitfall [0.03%]
经尿道膀胱肿瘤切除术中识别出前列腺腺癌——诊断相关的潜在陷阱的临床病理系列研究报告
Douglas Jian-Xian Wu,Richard Pacheco,Emily Chan et al.
Douglas Jian-Xian Wu et al.
Over the past 2 decades, we have increasingly encountered prostatic adenocarcinoma (PCA) presenting as urinary bladder tumors in routine practice as well as among consultation/medicolegal cases. Given the ramifications of a potential misdia...
Solid, cystic, and mucinous spindle cell thymomas (WHO type A): A clinicopathological and immunohistochemical study of 7 cases [0.03%]
固囊粘液型胸腺上皮性肿瘤（世界卫生组织A型）的临床病理及免疫组化特征（7例报告）
Annikka Weissferdt,Cesar A Moran
Annikka Weissferdt
Seven cases of an unusual thymoma subtype are presented. Patients included five men and two women, aged 43-57 years (mean: 50). Five patients presented with non-specific symptoms of cough, chest pain and shortness of breath; two patients we...
GRHL-rearranged sebaceoma: expanding the clinical and morphologic spectrum [0.03%]
GRHL重排的皮脂腺瘤：临床和形态学谱系的扩展
Anum Dileep,Christine J Ko,Robert E LeBlanc et al.
Anum Dileep et al.
Sebaceoma is a benign sebaceous neoplasm with broad architectural variability, and outside of mismatch repair (MMR)-deficient tumors, its molecular features have remained poorly defined. Recent work identified recurrent GRHL1/GRHL2 rearrang...
CDK12 Paradox in Breast Cancer: Loss-of-Function Fusion and Oncogenic Amplification as Dual Therapeutic Targets [0.03%]
乳腺癌中CDK12的悖论：失去功能的融合和致癌放大的双重治疗靶点
Chunqing Yu,Fangfang Yao,Dongbing Li et al.
Chunqing Yu et al.