Artificial intelligence-assisted screening for NTRK fusion-positive salivary gland tumors: A novel digital pathology workflow [0.03%]
基于人工智能的NTRK基因融合阳性唾液腺肿瘤筛查：一种新型数字病理学工作流程
Ryutaro Onaga,Shingo Sakashita,Daisuke Komura et al.
Ryutaro Onaga et al.
NTRK fusion is a promising therapeutic target for salivary gland cancer (SGC). However, the diagnostic complexity of the histological SGC subtype and low NTRK fusion-positive SGC incidence (5%), except for secretory carcinoma (90%), limit t...
Evaluation of Prognostic Factors and Outcomes in Primary versus Secondary Myeloid Sarcoma [0.03%]
原发性与继发性粒细胞肉瘤的预后因素及结局评估
Christine W Kahlow,Sharon Germans,Maximiliano Ramia de Cap et al.
Christine W Kahlow et al.
Myeloid sarcoma (MS) is a rare extramedullary manifestation of myeloid neoplasia that may present as an isolated disease without concurrent bone marrow involvement, primary disease or secondary to an antecedent myeloid neoplasm. The molecul...
The Farooq, Not the Lerner, Grading System Predicts Disease-Specific and Overall Survival in Duodenal Graft-Versus-Host Disease [0.03%]
Farooq分级而不是Lerner分级系统可预测肠移植物抗宿主病的疾病特异性和总生存率
Bei Yang,Reem Youssef,Omer Saeed et al.
Bei Yang et al.
Histopathological evaluation of graft-versus-host disease (GVHD) is crucial in its diagnosis. In the upper gastrointestinal tract, the duodenum has been reported as the most affected site. However, studies characterizing the features of duo...
A Report of Thirteen Non-Conventional FLCN-Mutated (Renal) Tumors (FMT) and a Discussion of Proposed Diagnostic Criteria, Convergent FLCN/TFEB and FLCN/MITF E318K Signaling, and FLCN immunohistochemistry [0.03%]
结节性硬化症综合症非 conventional BHD 基因突变 (肾脏) 肿瘤(FMT)的十五例报告及诊断标准、FLCN/TFEB 和 FLCN/MITF E318K 信号以及 FLCN 免疫组化的讨论
Sounak Gupta,Rosalie M Sterner,Hisashi Hasumi et al.
Sounak Gupta et al.
Background: Recent studies have demonstrated that FLCN-mutated tumors (FMT) represent a unique tumor type with dual FOXI1+ and L1CAM+ cell populations. Low-grade, well-circumscribed eosinophilic tumors (conventional FMT, ...
Histologic Spectrum of BRCA-Associated Pancreatic Ductal Adenocarcinoma : A Descriptive Morphologic Study [0.03%]
BRCA相关胰腺导管腺癌的组织病理谱系：一项描述性形态学研究
Gali Zabarsky Shasha,Maria Raitses-Gurevich,Chani Stossel et al.
Gali Zabarsky Shasha et al.
Context: Pancreatic ductal adenocarcinoma arising in carriers of germline BRCA1 or BRCA2 mutations represents a molecularly defined subgroup characterized by defective homologous recombination DNA repair, yet its histolog...
Pulmonary Venoocclusive Disease/Pulmonary Capillary hemangiomatosis: Inadequacy of Clinico-Radiologic Features in Diagnosis [0.03%]
肺静脉闭塞病/肺毛细血管血管内皮瘤：临床和影像表现的诊断不足
Philip Hurst,Darin White,Jay H Ryu et al.
Philip Hurst et al.
Pulmonary venoocclusive disease (PVOD)/pulmonary capillary hemangiomatosis (PCH) belongs to the WHO group 1 pulmonary hypertension (PH), labeled as pulmonary arterial hypertension (PAH), though it mainly involves pulmonary veins, venules an...
GPNMB immunohistochemistry distinguishes diagnostically challenging cases of lymphangioleiomyomatosis from other mesenchymal neoplasms presenting with cystic lung metastases [0.03%]
GPNMB免疫组化鉴别诊断淋巴管肌瘤病与其他具有囊性肺转移的间质肿瘤
Selina F Ji,Mark E Law,Jillian C Dawley et al.
Selina F Ji et al.
Lymphangioleiomyomatosis (LAM) is a low-grade neoplasm in the family of perivascular epithelioid cell (PEComa) tumors with myomelanocytic differentiation. Metastatic LAM causes cystic lung disease, but diagnosis may be hampered by low tumor...
CAR-T Cell Therapy and Its Complications: Role of the Pathologist in Diagnosis [0.03%]
CAR-T细胞治疗及其并发症：病理学家在诊断中的作用
Iman Sarami,L Jeffrey Medeiros
Iman Sarami
CAR-T cell therapy has transformed the treatment of patients with hematologic malignancies but has also introduced a spectrum of post-therapy complications that frequently require histopathologic evaluation. While clinical toxicities such a...
Multi-Omics Profiling Identifies HMGA2 Fusions as Defining a Distinct and Prognostically Favorable Subtype of Dedifferentiated Liposarcoma with Rhabdomyosarcomatous Differentiation [0.03%]
多组学谱分析识别HMGA2融合基因可定义具有横纹肌肉瘤分化的去分化脂肪肉瘤独特且预后良好的亚型
Xinke Zhang,Xiujiao Shen,Ping Chen et al.
Xinke Zhang et al.
Dedifferentiated liposarcoma (DDLPS) with rhabdomyosarcomatous differentiation is associated with a poorer prognosis compared to other DDLPS subtypes. This highlights the importance of exploring its clinicopathological, immune microenvironm...
Practical approaches to the diagnosis and differential diagnosis of T-lymphoblastic leukemia/lymphoma [0.03%]
T淋巴母细胞白血病/淋巴瘤诊断及鉴别诊断的临床思路
Wei J Wang,Joseph D Khoury,Hong Fang et al.
Wei J Wang et al.
T-lymphoblastic leukemia/lymphoma is a malignant neoplasm derived from T-cell precursors. These neoplasms can present initially as acute lymphoblastic leukemia (ALL) involving bone marrow or lymphoblastic lymphoma (LBL) involving lymph node...