M2 Polarization of RAW264.7-Derived Exosomes Inhibits Osteoclast Differentiation and Inflammation via PKM2/HIF-1α Axis [0.03%]
RAW264.7衍生的外泌体M2极化通过PKM2/HIF-1α轴抑制破骨细胞分化和炎症
Yue Zhang,Yufu Liang,Yue Zhou
Yue Zhang
Background: Periodontitis (PD) is a chronic inflammatory disease characterized by alveolar bone loss, primarily driven by excessive osteoclast differentiation and activation. Exosomes derived from M2 macrophages have been...
Genetic Differences Between N and J Sub-Strains of C57BL/6 Mice Critically Affect Multiple Immune Responses and Their Microbiota [0.03%]
遗传差异影响小鼠的多种免疫反应及其微生物群落 состав
Andreas Hiergeist,Sarah Miksch,Nicole Sabouret et al.
Andreas Hiergeist et al.
Background: Within decades of breeding, the common laboratory mouse strain C57BL/6 (B6) divided into various sub-strains with B6J and B6N being most frequently used. Recent studies showed significant genetic differences a...
T Cells Expressing Ras Homolog Family Member a Display Enhanced Cytotoxicity but are Reduced in Lupus Peripheral Blood [0.03%]
Ras同源家族成员A表达的T细胞在狼疮外周血中表现出增强的细胞毒性和减少数量
Ziqi Xiong,Zhao Guan,Ainizati Hasimu et al.
Ziqi Xiong et al.
Objective: This study aimed to explore the expression and clinical relevance of Ras homolog family member A (RhoA) in T cell subsets from patients with systemic lupus erythematosus (SLE). ...
Psoriasis Relapse: Exploring the Role of Epigenetics, Metabolic Reprogramming, and Inflammatory Memory [0.03%]
银屑病复发：表观遗传学、代谢重编程和炎症记忆的作用机制探索
Sakshi Wadhavane,Arulkumaran Rithvik,Mahaboobkhan Rasool
Sakshi Wadhavane
Background: Psoriasis is a chronic autoimmune condition characterized by recurrent episodes of skin inflammation. Despite progress in treatment, managing flare-ups of psoriasis remains a significant hurdle once the therapy is halted. This r...
DNA methylation and transcriptome signatures of the FOXO1 gene in ankylosing spondylitis [0.03%]
ANK病患者FOXO1基因DNA甲基化及转录组特征分析
Xiaohan Jing,Li Fan,Yuan Wang et al.
Xiaohan Jing et al.
Background: Ankylosing spondylitis (AS) is an inflammatory autoimmune disease with complex etiology. The forkhead box O (FOXO) 1 is an important transcription factor related to proliferation, homeostasis and metabolism. N...
Expression of the Transcription Factor FOXP3 in Human Peripheral Blood B-Cell Subtypes (CD19+CD39+ and CD19+CD39-) and Evaluation of Their Regulatory Function [0.03%]
人外周血B细胞亚群（CD19+CD39+和CD19+CD39-）中转录因子FOXP3的表达及其调节功能的评估
A Cardenas-Juarez,E E Uresti-Rivera,F Ochoa-González et al.
A Cardenas-Juarez et al.
Introduction: The aim of this study was to evaluate FOXP3 expression in CD19+CD39+ and CD19+CD39- B cells, and to investigate its potential regulatory role. ...
Hypoxic ADSC Exosomes Alleviate Primary Sjögren's Syndrome-Induced Skin Injury via GLRX2 Delivery and Ferroptosis Suppression [0.03%]
缺氧ADSC外泌体通过GLRX2递送和铁死亡抑制缓解原发性舍格伦综合征诱导的皮肤损伤
Xin Wang,Fengjiao Wu,Xinmeng Yang et al.
Xin Wang et al.
Background: The aim of the present study was to assess the therapeutic effects of ADSC-Exos for SS-induced skin injury. Methods: A mous...
M1 Monocyte Polarization and Deficient Immunomodulation in Preeclampsia [0.03%]
重度子痫前期中M1单核细胞极化与免疫调节功能缺陷的关系研究
Mariana Romao-Veiga,Amanda Carreira Devides,Vanessa Rocha Ribeiro-Vasques et al.
Mariana Romao-Veiga et al.
Introduction: Preeclampsia (PE) is a specific pregnancy syndrome characterized by a systemic inflammatory response that may be dependent on the presence of danger molecules called damage-associated molecular patterns (DAM...
Recombinant Protein UBC13 Improves Tissue Injury of MRL/Lpr Mice by Alleviating Th1/Th2 Immune Imbalance [0.03%]
重组UBC13蛋白通过改善MRL/lpr小鼠Th1/Th2免疫失衡提高组织损伤修复能力
Mengchen Qi,Qian Li,Bingyao Ren et al.
Mengchen Qi et al.
Objectives: This study aimed to investigate the role of T-cell imbalance in the pathogenesis of systemic lupus erythematosus (SLE), the role of Ubiquitin-binding enzyme 2N (UBC13) in the treatment of SLE. ...
Indoleamine 2,3-Dioxygenase and Tryptophan Catabolism: Key Players in Immunosuppression and Intracellular Parasite Survival Mechanisms [0.03%]
吲哚胺2，3-双加氧酶和色氨酸降解产物：免疫抑制及胞内寄生虫存活机制中的关键因素
Lisset Torres-Martínez,Abraham U Morales-Primo,Jaime Zamora-Chimal
Lisset Torres-Martínez
Background: Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that catalyzes the oxidative degradation of L-tryptophan (L-Trp) through the kynurenine pathway (KP), generating metabolites that regulate immune responses. T...