Aflatoxin B1 Instigated Redox Imbalance is Accompanied by Amplified Indoleamine 2,3-Dioxygenase/tryptophan Catabolism in the Spleen and Erythrocyte of Male Wistar Rats: Protective Influence of Dietary Rutin [0.03%]
饮食芦丁对雄性Wistar大鼠肝脏中黄曲霉毒素B1诱发的氧化应激失衡及脾和红细胞中吲哚胺2,3-双氧酶/色氨酸代谢增强的影响研究
Azubuike Peter Ebokaiwe,Nworie Okoro,Doris Olachi Alilonu et al.
Azubuike Peter Ebokaiwe et al.
Introduction: Rutin, a dietary flavonoid, exhibits anti-inflammatory, antioxidant, and immunomodulatory properties. The underlying mechanism of protection of rutin against Aflatoxin B1 (AFB1)-induced immunotoxicity is not...
FOXM1 Enhances Transcription of S1PR1 and Promotes Pro-Inflammatory Activation of Kupffer Cells in Alcoholic Hepatitis [0.03%]
FOXM1通过增强S1PR1转录促进酒精性肝炎状态下枯否细胞的促炎症活化
Ping Lu,Tianfeng Sun
Ping Lu
Background: Following the bioinformatics predictions, this investigation delves into the function of FOXM1 in the phenotype of macrophages and inflammatory responses in alcoholic hepatitis (AH). ...
Activation of NF-κB Signaling by a High-Fat and High-Sugar Diet Enhances Macrophage Polarization and Aggravates Postoperative Pain and Inflammatory Responses [0.03%]
高脂高糖饮食通过活化NF-κB信号促进巨噬细胞极化并加剧术后疼痛及炎症反应
Chenran Zhang,Ming Zhu
Chenran Zhang
Objective: To investigate how a high-fat, high-sugar (HFHS) diet influences postoperative pain and inflammation, and to explore the role of NF-κB signaling and macrophage polarization. ...
Mechanistic Insights into HOTAIR-Driven ADAM17/NF-Κb Activation and Endothelial Dysfunction in LPS-Challenged HUVECs [0.03%]
HOTAIR驱动的ADAM17/NF-κB活化及LPS刺激HUVEC内皮功能障碍的机制研究
Junbing He,Zixuan Shao,Zhuoji Li et al.
Junbing He et al.
Introduction: HOX transcript antisense intergenic RNA (HOTAIR) has been implicated in inflammation and vascular pathology, but its role in regulation of ADAM17 and sepsis-induced endothelial injury remains unclear. ...
IL-37 Alleviates Sepsis-Induced Lung Injury by Inhibiting Inflammatory Response Through the TGF-β/Smad3 Pathway [0.03%]
通过转化生长因子-β/Smad3信号通路抑制炎症反应缓解白细胞介素-37诱导的肺损伤
Yufang Guo,Feifei Deng,Yali Jiang et al.
Yufang Guo et al.
Introduction: Sepsis is caused by an uncontrolled inflammatory response and immune dysfunction, with lung injury being the most common complication and one of the leading causes of death in clinically ill patients. Interleukin 37 (IL-37) is...
The Power of Antibodies: Advancing Biomarker-Based Disease Detection and Surveillance [0.03%]
抗体的力量：推进基于生物标志物的疾病检测和监测
Woei Kean Ng,Gunasegran Thanusha,Pei Pei Chong et al.
Woei Kean Ng et al.
Background: Antibodies have long served as fundamental tools in disease diagnosis and surveillance. Their utility as biomarkers has expanded beyond infectious diseases to encompass a wide range of health conditions. ...
Macrophage Polarization in Lung Diseases: From Mechanisms to Therapeutic Strategies [0.03%]
肺部疾病中的巨噬细胞极化：从机制到治疗策略
Jia Wang,Huajie Niu,Junwei Kang et al.
Jia Wang et al.
Macrophages are pivotal immune cells involved in maintaining immune homeostasis and defending against pathogens. They exhibit significant plasticity and heterogeneity, enabling polarization into pro-inflammatory M1 or anti-inflammatory M2 p...
Markers of Endotoxemia and Inflammation are Associated with Digital Ulcers in Systemic Sclerosis Patients [0.03%]
内毒素血症和炎症因子与系统性硬化病患者指溃疡的相关性研究
Chiara Pellicano,Alessandra Oliva,Amalia Colalillo et al.
Chiara Pellicano et al.
Background: The aim of this study was to evaluate the possible role of lipopolysaccharide-binding protein (LBP) and interleukin 6 (IL-6) in the development of digital ulcers (DUs) in Systemic sclerosis (SSc). ...
The Lasting Impact of IL-2: Approaching 50 Years of Advancing Immune Tolerance, Cancer Immunotherapies, and Autoimmune Diseases [0.03%]
IL-2的持久影响：推进免疫耐受、癌症免疫疗法和自身免疫疾病接近50年
Prajita Paul,Cherry Choong,Joseph Heinemann et al.
Prajita Paul et al.
Background: The discovery of interleukin-2 (IL-2) and its receptor (IL-2R) almost 50 years ago revolutionized immunology, marking a pivotal moment in understanding T cell biology and immune regulation. Initially identifie...
Immunomodulatory Role and Therapeutic Potential of HLA-DR+ Regulatory T Cells in Systemic Lupus Erythematosus [0.03%]
HLA-DR+调节性T细胞在系统性红斑狼疮中的免疫调节作用和治疗潜能
Jing Zhang,Bei Liao,Xiaobing Wang et al.
Jing Zhang et al.
Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organ systems. A key element in maintaining immune tolerance and preventing autoimmunity is the role of regulatory T cel...