Decoding the Skin Micro-Immune Milieu, Homeostasis, and Keratinocyte Trafficking in Psoriatic Disease [0.03%]
Ishu Garg,Neelam Singh,Shivani Rawat et al.
Ishu Garg et al.
Introduction: The skin, acting as a complex interface between the immune system and microbiome, maintains balance through coordinated interactions among the epidermal barrier, microbiome, and immune responses. Psoriasis, ...
UBE2I Alleviates Pyroptosis in Coronary Heart Disease by Promoting the SUMOylation and Degradation of NLRP3 [0.03%]
Sheng-Kai Ding
Sheng-Kai Ding
Objective: Coronary heart disease (CHD), a major cardiovascular disorder, involves myocardial injury, inflammation, and fibrosis. NLRP3 inflammasome-driven pyroptosis plays a critical role in CHD progression. Although the...
Fei Li,Wenjing Gong,Aina Liu
Fei Li
Background: Tertiary lymphoid structures (TLSs), also known as ectopic lymphoid aggregates, have been increasingly recognized as important components of the tumor microenvironment. In gastric cancer, the presence, composi...
The STING Signaling Pathway in Prostate Cancer: Mechanisms, Influencing Factors, and Therapeutic Strategies [0.03%]
前列腺癌中的STING信号通路：机制、影响因素及治疗策略
Na Qu,Meng Zhang,Yating Ji et al.
Na Qu et al.
Background: Prostate cancer (PCa) is a common malignancy in men globally. The cGAS-STING pathway shows promise in its treatment as it can enhance anti-tumor immunity and promote immunogenic cell death. However, the tumor ...
Astragalus Polysaccharide Promotes NLRP3+ Macrophages Polarization via Suppression of OGT in Hepatocellular Carcinoma [0.03%]
黄芪多糖通过抑制OGT促进NLRP3+肝癌巨噬细胞极化的作用及机制研究
Yaping Lv,Mingyun Ma,Xiaobo Zhu et al.
Yaping Lv et al.
Background: Hepatocellular carcinoma (HCC) is characterized by an immunosuppressive tumor microenvironment (TME) dominated by tumor-associated macrophages (TAMs). Astragalus polysaccharide (APS) exhibits anti-tumor activi...
The Causal Role of Circulating Inflammatory Cytokines in Brain Tumors: Insights from Genetic Epidemiology [0.03%]
遗传流行病学在脑肿瘤中循环炎症细胞因子的因果作用：来自遗传流行病学的新见解
Teng Qi,Lingjun Yao,Zheyu Wen et al.
Teng Qi et al.
Background: Previous studies indicate associations between inflammatory cytokines and glioma, meningioma, and astrocytoma. Methods: We ...
CD4-CD8-T Cell Reconstitution Combined with Acute GVHD and CMV Infection: A Robust Predictor of Overall Survival and Non-Relapse Mortality After HSCT [0.03%]
CD4-CD8-T细胞再构成结合急性GVHD和CMV感染：造血干细胞移植后总生存率和非复发死亡率的强大预测指标
Xiaoling Wang,Liang Zhao,Chao Han et al.
Xiaoling Wang et al.
Background: Immune reconstitution (IR), acute graft-versus-host disease (aGVHD), and cytomegalovirus (CMV) infection are all crucial factors influencing the prognosis following hematopoietic stem cell transplantation (HSC...
Propofol Exerted an Anti-Asthmatic Effect by Attenuating Extracellular Matrix Deposition and Viability of Airway Smooth Muscle Cells [0.03%]
丙泊酚通过减少气道平滑肌细胞的存活和细胞外基质沉积发挥其抗哮喘作用
Zhenzhen Chen,Yanyan Jiang,Hua Zhang et al.
Zhenzhen Chen et al.
Introduction: Propofol is the preferred anaesthetic for asthma patients due to its bronchodilatory effects, yet its protective mechanisms remain unclear. This study investigated its effects both in vivo and in vitro. ...
Immunometabolic Dysregulation in Psoriasis: Mechanisms Driving Inflammation and Emerging Therapeutic Targets [0.03%]
银屑病的免疫代谢紊乱：驱动炎症的机制和新兴治疗靶点
Aditya Jaswal,Aman Kumar,Preeti Patel et al.
Aditya Jaswal et al.
Background: Psoriasis is increasingly recognized as a systemic immuno-metabolic disorder in which chronic inflammation interacts with alterations in cellular energy metabolism. ...
Differences in Shared T Cell receptor α Repertoire Associated with Recognition of Viral Antigens [0.03%]
与识别病毒抗原相关的共享T细胞受体α库的差异
Tiitus Lamponen,Joonatan Mattila,Nelli Heikkilä et al.
Tiitus Lamponen et al.
Background: Despite the high diversity of the αβ T cell receptor (TCR), sharing of identical TCR chains between individuals is common. This shared repertoire consists mainly of chains with few non-germline nucleotide ad...