KEAP1-Nrf2 Signaling in Chronic Inflammatory Disorders: Integrating Redox Biology, Quantitative Evidence, and Precision Therapeutics [0.03%]
慢性炎症障碍中的KEAP1-Nrf2信号转导：整合氧化还原生物学、定量证据和精准治疗学
Abdul Shadab
Abdul Shadab
Background: Chronic inflammatory disorders represent a major global health burden characterized by persistent immune activation, oxidative stress, and progressive tissue dysfunction. Dysregulated redox signaling has posit...
Single-Cell Transcriptional States of Human Leukocyte Antigen DR Positive CD4 Positive T Cells Linked to Genetic Susceptibility of Gastric Cancer [0.03%]
胃癌遗传易感性相关的HLA-DR阳性CD4阳性T细胞单细胞转录组状态
Yicun Song,Haoran Zhu,Cong Qiao et al.
Yicun Song et al.
Background: Gastric cancer (GC) involves complex immune-metabolic crosstalk, but MR-prioritized immunophenotypes and mediating metabolites remain unclear. ...
γδ T Cells as a Platform for Immunotherapy: From Biological Principles to Clinical Translation [0.03%]
基于γδT细胞的免疫治疗研究：从生物学原理到临床转化
Junjie Ni,Chao Xiong,Xian Wu et al.
Junjie Ni et al.
Background: γδ T cells are emerging as a promising immunotherapy platform because they combine rapid innate-like effector activity with adaptive immune features and recognize stress-associated signals in a largely MHC-independent manner. ...
Numb Mediates IL-1β/TGF-β1-Driven Inflammation-Fibrosis Coupling in Idiopathic Pulmonary Fibrosis [0.03%]
NUMB介导IL-1β/TGF-β1驱动的特发性肺纤维化炎症-纤维化偶联反应
Debin Zhuo,Shanzuan Wang,Juan Lin et al.
Debin Zhuo et al.
Background: In idiopathic pulmonary fibrosis (IPF), inflammatory signaling and fibrotic remodeling often coexist, yet the mechanism linking these processes remains unclear. Numb, a cell fate determinant protein, has been ...
Precision Warfare in Solid Tumors: Molecular Mechanisms and Emerging Frontiers of Antibody-Drug Conjugates [0.03%]
固态肿瘤的精准治疗：抗体药物偶联物的分子机制和新兴前沿领域
Hanandha Putra Luqmana,Ami Ashariati,Merlyna Savitri et al.
Hanandha Putra Luqmana et al.
Background: Antibody-drug conjugates (ADCs) have transformed the treatment of solid tumors by combining the tumor specificity of monoclonal antibodies with highly potent cytotoxic payloads. Advances in ADC engineering have expanded their cl...
Interferon-Associated Antiviral Programs Define LAG-3+ Exhaustion-Like CD8+ T-Cell Remodeling in Influenza a Virus Infection: An Integrative Single-Cell and Multi-Cohort Analysis [0.03%]
干扰素相关抗病毒程序定义了流感病毒感染中LAG-3+耗竭样CD8+T细胞重塑：整合单细胞和多队列分析
Yecheng Zhou,Jianing Wang,Jingyan Xu et al.
Yecheng Zhou et al.
Background: Influenza A virus (IAV) infection induces complex antiviral immune responses, yet how innate sensing, host genetic susceptibility, and adaptive immune dysfunction converge remains incompletely understood. This...
Dual Faces of Immune Regulation: The Roles of Tregs and Bregs in Helicobacter pylori Infection and Therapeutic Implications [0.03%]
免疫调节的双重作用：Tregs和Bregs在幽门螺杆菌感染中的作用及治疗意义
Watiqah Wahid,Barathan Muttiah,Alfizah Hanafiah
Watiqah Wahid
Background: Helicobacter pylori maintains life-long colonization even though it triggers a strong immune response. This phenomenon is mainly related to regulatory immune responses involving regulatory T cells (Tregs) and regulatory B cells ...
SKAP1, FYN and CD3E Are Potential Biomarkers and Therapeutic Targets of Sepsis [0.03%]
SKAP1、FYN和CD3E是脓毒症的潜在生物标志物和治疗靶点
Xingkai Shen,Jian Guo,Kaili Yang et al.
Xingkai Shen et al.
Background: Sepsis is a systemic inflammatory response caused by pathogen infection, leading tomultiple organ failure. This study aims to identify potential sepsis biomarkers. ...
The Microglial NLRP3 Inflammasome in Multiple Sclerosis: Bridging Innate Immunity, Chronic Inflammation, and IFN-β Response [0.03%]
小胶质细胞NLRP3炎性体与多发性硬化：连接先天免疫、慢性炎症和IFN-β反应
Prathyusha Koyya,Hemasundar Alavilli,Santhi Latha Pandrangi et al.
Prathyusha Koyya et al.
Background: Multiple sclerosis (MS) is a chronic neurodegenerative and demyelinating disease that is marked by chronic inflammation of the central nervous system (CNS). Although interferon-β (IFN-β) remains one of the pillars of treatment...
The ATG14-SIRT1 Axis Modulates NF-Κb Pathway Activation and Inflammatory Responses in Acute Lung Injury [0.03%]
ATG14-SIRT1轴调节急性肺损伤中的NF-κB信号途径和炎症反应
Yali Wang,Zilong Liu,Haiying Ji et al.
Yali Wang et al.
Background: Acute lung injury (ALI) is characterized by dysregulated inflammation and tissue damage. Autophagy-related gene 14 (ATG14) is a key autophagy regulator, but its role in ALI remains incompletely understood. ...