An overview of periconceptional pathology and pathophysiology: Where do we go next? [0.03%]
围孕期病理和病理生理概览：未来方向何去何从？
James M Roberts,Graham J Burton,Kirk P Conrad et al.
James M Roberts et al.
It is becoming increasingly evident that studies of pregnancy and pregnancy complications must begin earlier in pregnancy than has typically been the case. Important events with effects through and beyond pregnancy take place in the pericon...
Gestational TCBPA exposure impairs placental function and fetal Development: Mechanisms of syncytialization disruption and fetal growth restriction [0.03%]
孕期TCBPA暴露损害胎盘功能并影响胎儿发育：合体化障碍和胎儿生长受限的机制研究
Siyu Wang,Shufang Wang,Xin Zhang et al.
Siyu Wang et al.
Introduction: Tetrachlorobisphenol A (TCBPA), a BPA alternative, has been identified as a potential toxin, yet its reproductive toxicity remains poorly understood. This study aimed to investigate the effects of gestationa...
Single cell RNA-sequencing reveals BHLHE40 and NDRG1 as key regulatory molecules modulating the trophoblastic senescence in preeclampsia [0.03%]
单细胞RNA测序揭示BHLHE40和NDRG1是调节子痫前期滋养层衰老的关键调控分子
Yang Zhang,Jie Chu,Zhicheng Yu et al.
Yang Zhang et al.
Introduction: Preeclampsia (PE) is a severe obstetric complication characterized by trophoblastic dysfunction and compromised placental development. Cellular senescence has been notably reported in PE trophoblasts, which ...
Disruption of LDL receptor trafficking in placentas from maternal supraphysiological hypercholesterolemia: A study of key endocytosis and recycling proteins [0.03%]
母体超生理高胆固醇血症胎盘LDL受体运输中断——关于关键内吞和回收蛋白的研究
Andrea Morales,Nicolás Riquelme,Sebastián E Illanes et al.
Andrea Morales et al.
Introduction: During pregnancy, some women experience elevated cholesterol levels, known as maternal supraphysiological hypercholesterolemia (MSPH), which can cause oxidative stress and endothelial dysfunction in the fetu...
Insufficient expression of VTN promotes the development of early-onset severe preeclampsia through the HEY1/autophagy signaling pathway [0.03%]
VTN表达下调通过HEY1/自噬信号通路促进早期重度子痫前期发病发展
Gonghua Qi,Yanmin Gong,Yi Li et al.
Gonghua Qi et al.
Introduction: Early-onset severe preeclampsia (eosPE) is a serious pregnancy complication that affects maternal and fetal health. This study aims to identify genes involved in the development of eosPE by analyzing placent...
Safety assessment of drugs in pregnancy: An update of pharmacological models [0.03%]
孕期药物安全评估：药理学模型的更新
Lunbo Tan,Dongni Huang,Huisheng Ge et al.
Lunbo Tan et al.
Pregnant women are largely excluded from clinical drug trials due to ethical concerns, leading to a critical knowledge gap in medication safety during pregnancy. Indeed, over 90 % of approved drugs lack pharmacokinetic data in pregnant pati...
Physiological glucose levels associated with gestational diabetes impact the human placental transcriptome in an ex vivo model [0.03%]
生理性血糖水平与妊娠糖尿病对离体人胎盘转录组的影响
Abigail R Byford,Katy Walsh,Dapeng Wang et al.
Abigail R Byford et al.
Introduction: Gestational diabetes mellitus (GDM) increases the risk of pathological fetal growth, including rates of large-for-gestational age (LGA) infants, which in turn increases the risk of offspring later developing...
Polystyrene microplastics internalization by term placental chorionic villi explants [0.03%]
胎盘终末绒毛外植体摄取聚苯乙烯微塑料及其对屏障功能的影响研究
Aldilane Lays Marques,Rodrigo Weingrill,Stephanie Ospina-Prieto et al.
Aldilane Lays Marques et al.
Introduction: Microplastics (MPs) are pervasive environmental contaminants increasingly found within human tissues, including the placenta. This study explores the potential of polystyrene (PS)-MPs to cross the placental ...
A human cytotrophoblast-villous endothelium-fetal organ multi-cell model and the impact on gene and protein expression in placenta cytotrophoblast, fetal hepatocytes and fetal kidney epithelial cells [0.03%]
人类合胞体-绒毛内皮-胎儿器官多细胞模型及其对胎盘合胞体、胎儿肝细胞和胎儿肾上皮细胞基因表达与蛋白质表达的影响
Helen N Jones,Alyssa Williams,Rebecca L Wilson
Helen N Jones
Introduction: Appropriate fetal growth requires multi-directional, coordinated communication between maternal, placental, and fetal systems. Disruptions in these signaling arms can have deleterious consequences for fetal ...
Molecular regulation and functional benefits of trophoblast syncytialization in optimizing maternal-fetal nutrient allocation [0.03%]
细胞同步带化分子调控及优化母胎营养分配的功能益处
Qianqian Li,Yuelin Zhu,Xin Yu et al.
Qianqian Li et al.
The placenta governs maternal-fetal nutrient allocation during pregnancy, primarily mediated by placental villi composed of multinucleated syncytiotrophoblasts (STBs) and mononucleated cytotrophoblasts (CTBs) in humans. STBs are formed thro...