Revolutionising healing: Gene Editing's breakthrough against sickle cell disease [0.03%]
革新治愈方法：基因编辑在对抗镰状细胞贫血方面的突破
Marija Dimitrievska,Dravie Bansal,Marta Vitale et al.
Marija Dimitrievska et al.
Recent advancements in gene editing illuminate new potential therapeutic approaches for Sickle Cell Disease (SCD), a debilitating monogenic disorder caused by a point mutation in the β-globin gene. Despite the availability of several FDA-a...
Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy? [0.03%]
通过抑制E-选择素来针对血液恶性肿瘤：AML治疗的甜点？
注释：“甜点”在这里是直译，但在医学研究背景下可能不太适用。一个更准确和通顺的翻译可能是“是否找到了AML治疗的关键？” 或者 “靶向抑制E-选择素：为AML治疗找到关键了吗？” 这里的“关键”是指可能的有效治疗方法或突破点。
Geoffrey L Uy,Daniel J DeAngelo,Jay N Lozier et al.
Geoffrey L Uy et al.
E-selectin, a cytoadhesive glycoprotein, is expressed on venular endothelial cells and mediates leukocyte localization to inflamed endothelium, the first step in inflammatory cell extravasation into tissue. Constitutive marrow endothelial E...
Depression in patients with hematologic malignancies: The current landscape and future directions [0.03%]
血液恶性肿瘤患者中的抑郁现状及未来方向
Thomas M Kuczmarski,Lizabeth Roemer,Oreofe O Odejide
Thomas M Kuczmarski
Patients with hematologic malignancies experience high rates of depression. These patients are vulnerable to depression throughout the disease trajectory, from diagnosis to survivorship, and at the end of life. In addition to the distressin...
The role of preoperative transfusion in sickle cell disease, a systematic review and meta-analysis [0.03%]
术前输血在镰状细胞疾病中的作用，系统评价和荟萃分析
Yasamin Abdu,Alaa Rahhal,Khalid Ahmed et al.
Yasamin Abdu et al.
This systematic review and meta-analysis aimed to provide guidance on preoperative blood transfusion strategies for patients with sickle cell disease (SCD). We included all randomized controlled and observational studies exploring the clini...
Quality of life, mood disorders, and cognitive impairment in adults with β-thalassemia [0.03%]
β-地中海贫血成人患者的生活质量，情绪障碍和认知损害
Maya Bizri,Rawan Koleilat,Nathalie Akiki et al.
Maya Bizri et al.
Advances in understanding the disease process in β-thalassemia supported development of various treatment strategies that resulted in improved survival. Improved survival, however, allowed multiple morbidities to manifest and cemented the ...
Prevention and management of infectious complications in patients with chronic lymphocytic leukemia (CLL) treated with BTK and BCL-2 inhibitors, focus on current guidelines [0.03%]
慢性淋巴细胞白血病(BTK和BCL-2抑制剂治疗的感染并发症的预防与管理，重点关注当前指南
Malgorzata Mikulska,Chiara Oltolini,Emanuela Zappulo et al.
Malgorzata Mikulska et al.
CLL is associated with an increased risk of infectious complications. Treatment with BTK or BCL-2 inhibitors does not seem to increase significantly the risk of opportunistic infections, but the role of combination therapies including BTK a...
When anticoagulation management in atrial fibrillation becomes difficult: Focus on chronic kidney disease, coagulation disorders, and cancer [0.03%]
当房颤抗凝管理变得困难时：重点探讨慢性肾脏疾病、凝血障碍和癌症
Panteleimon E Papakonstantinou,Vasiliki Kalogera,Dimitrios Charitos et al.
Panteleimon E Papakonstantinou et al.
Anticoagulation therapy (AT) is fundamental in atrial fibrillation (AF) treatment but poses challenges in implementation, especially in AF populations with elevated thromboembolic and bleeding risks. Current guidelines emphasize the need to...
Harnessing multi-source data for individualized care in Hodgkin Lymphoma [0.03%]
利用多源数据进行霍奇金淋巴瘤的个体化治疗
Susan K Parsons,Angie Mae Rodday,Jenica N Upshaw et al.
Susan K Parsons et al.
Hodgkin lymphoma is a rare, but highly curative form of cancer, primarily afflicting adolescents and young adults. Despite multiple seminal trials over the past twenty years, there is no single consensus-based treatment approach beyond use ...
Update: The molecular spectrum of virus-associated high-grade B-cell non-Hodgkin lymphomas [0.03%]
更新：病毒相关高级别B细胞非霍奇金淋巴瘤的分子谱分析
H Witte,A Künstner,N Gebauer
H Witte
The vast spectrum of aggressive B-cell non-Hodgkin neoplasms (B-NHL) encompasses several infrequent entities occurring in association with viral infections, posing diagnostic challenges for practitioners. In the emerging era of precision on...
Disparity in hematological malignancies: From patients to health care professionals [0.03%]
血液恶性肿瘤的差异：从患者到医疗卫生专业人员的观点
Xiaoyi Chen,Mihir Shukla,Shella Saint Fleur-Lominy
Xiaoyi Chen
In the recent few decades, outcomes in patients diagnosed with hematological malignancies have been steadily improving. However, the improved prognosis does not distribute equally among patients from different backgrounds. Besides cancer bi...