Adenovirus infection in adult allogeneic hematopoietic stem cell transplant recipients: Systematic review and meta-analysis [0.03%]
成人同种异体造血干细胞移植受者腺病毒感染的系统评价和荟萃分析
Nadir Ullah,Marco Muccio,Claudia Bartalucci et al.
Nadir Ullah et al.
Adenovirus (AdV) infection in adult patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) is associated with poor outcomes but management strategies differ among the centers. Data on incidence and risk factors for AdV...
Long-term durability of rAAV gene therapy in hemophilia: Factor expression, clinical outcomes and underlying molecular mechanisms [0.03%]
基于rAAV基因治疗的血友病长期疗效及机制研究
Yesim Dargaud,Gabriela G Yamaguti-Hayakawa,Jéssica O Frade-Guanaes et al.
Yesim Dargaud et al.
For decades, the management of hemophilia A and B has relied on frequent intravenous infusions of factor VIII (FVIII) or factor IX (FIX), a regimen that imposes substantial physical and emotional burdens on patients, and carries significant...
The microbiome-lymphoma Axis: A systematic review and Meta-analysis of gut Dysbiosis pattern in diffuse large B-cell lymphoma [0.03%]
微生物组与淋巴瘤轴线：弥漫性大B细胞淋巴瘤肠道菌群失调模式的系统评价和荟萃分析
Sarah A Elkourashy,Rasha Abu-El-Ruz,Medhat Z Askar et al.
Sarah A Elkourashy et al.
Background: Gut microbiota has emerged as a critical mediator of immune homeostasis and cancer biology. Increasing evidence suggests that gut dysbiosis may play a significant role in the pathogenesis of diffuse large B-ce...
Redefining central nervous system multiple myeloma: From rare phenomenon to emerging entity [0.03%]
中枢神经系统多发性骨髓瘤：从罕见现象到新兴实体
Ian Landry,Adam F Binder,Marc Yorker et al.
Ian Landry et al.
Background: Central nervous system involvement in multiple myeloma (CNS-MM) is considered a rare but devastating manifestation of extra-medullary disease (EMD) associated with aggressive biology and dismal outcomes. Treat...
Bispecific antibodies in multiple myeloma: maximizing potential through rational combination therapies [0.03%]
双特异抗体在多发性骨髓瘤中的应用：通过理性联合治疗最大化其潜力
Xiang Zhou,Johannes M Waldschmidt,Hermann Einsele
Xiang Zhou
Bispecific antibodies have emerged as a transformative immunotherapeutic strategy in multiple myeloma (MM). Early constructs such as BiTEs paved the way for full-length IgG-based antibodies with improved pharmacokinetics and safety profiles...
Artificial intelligence in myeloid malignancies: Clinical applications of machine learning in myelodysplastic syndromes and acute myeloid Leukemia [0.03%]
人工智能在髓系肿瘤中的应用：机器学习在我elodysplastic综合征和急性髓性白血病中的临床应用
Jowan Al-Nusair,Luca Lanino,Arda Durmaz et al.
Jowan Al-Nusair et al.
This review summarizes applications of machine learning (ML) in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), spanning diagnosis, prognostication, treatment prediction, and research tools. In diagnostics, deep learning ap...
Management of relapsed refractory multiple myeloma: Evidence-based guide to community oncologists [0.03%]
复发难治性多发性骨髓瘤的管理——基于证据的社区肿瘤科医师指导指南
Ali Mushtaq,Asfand Yar Cheema,Hossam M Ali et al.
Ali Mushtaq et al.
Multiple myeloma (MM), a clonal plasma cell malignancy, presents a therapeutic challenge, especially in selecting therapy for patients with relapsed/refractory MM (RRMM). Up to 1-3 prior lines of therapy in this population are considered ea...
Metabolomics in sickle cell disease: Current knowledge and gaps - A scoping review [0.03%]
镰状细胞病代谢组学的研究现状与不足——系统综述
Sigrid van der Veen,Judith J M Jans,Eduard J van Beers et al.
Sigrid van der Veen et al.
Sickle cell disease (SCD) has large phenotypic variability. Systematic metabolomic profiling may provide insights into phenotypes and treatment responses. We conducted a scoping review on associations between blood metabolites, SCD-related ...
Old tests and new paradigms: How to interpret iron studies and related biomarkers for the diagnosis of iron deficiency in adults [0.03%]
旧的试验与新的范式：铁缺乏成人中铁状态检测及生物标志物解读的策略
Magdalena Kriel,Jessica Opie,Jody Rusch et al.
Magdalena Kriel et al.
Clinicians need a good understanding of available tools to diagnose iron deficiency (ID). Interpretation of commonly used laboratory tests can be challenging due to the dynamic nature of iron homeostasis and concurrent inflammation, which i...
DecodingAcute GVHD: The role of serum biomarkers and imaging in diagnosis and management [0.03%]
急性GVHD的诊断和管理中的血清生物标志物和影像的作用
Rohit Singh,Happy Agarwal,Ryan Bynum et al.
Rohit Singh et al.
Graft-versus-host disease (GVHD) is one of the major barriers to the clinical success of hematopoietic stem cell transplantation (HCT). Despite improvements in GVHD incidence with the use of post-transplant cyclophosphamide, cord blood tran...