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Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy?

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E-selectin, a cytoadhesive glycoprotein, is expressed on venular endothelial cells and mediates leukocyte localization to inflamed endothelium, the first step in inflammatory cell extravasation into tissue. Constitutive marrow endothelial E-selectin expression... ...