MEIS1::NCOA1 Primitive Spindle Cell Sarcoma of the Kidney: Report of 7 Cases of a Distinctive Clinicopathologic Entity [0.03%]
MEIS1::NCOA1原始纺锤细胞肾脏肉瘤：7例独特临床病理实体报告
Pedram Argani,Sintawat Wangsiricharoen,Maria Tretiakova et al.
Pedram Argani et al.
Primitive sarcomas harboring the MEIS1::NCOA2 gene fusion were originally described in the kidney in 2018, and subsequently reported in other organs. These variably cellular neoplasms feature monomorphic primitive plump spindle cells formin...
CDKN2A Chromogenic In Situ Hybridization for Separating Benign From Malignant Mesothelial Proliferations [0.03%]
用于区分良性与恶性间皮增生的CDKN2A染色原位杂交技术
Andrew Churg,Tara Spence,Karina C Martin et al.
Andrew Churg et al.
CDKN2A FISH is a standard method for separating mesotheliomas from reactive mesothelial proliferations, but FISH requires specialized equipment and technical expertise for interpretation. Here, we show that a commercially available CDKN2A C...
High-Grade Papillary Thyroid Carcinoma, Diffuse Sclerosing Subtype: A Series of 18 Cases Detailing the Pathologic Features, Potential for Misdiagnosis, and Aggressive Clinical Behavior [0.03%]
高分化乳头状甲状腺癌，弥散硬化亚型：18例病例系列，详细描述病理特征，误诊潜力及侵袭性临床行为
Ronald A Ghossein,Daniel W Scholfield,Howard Qin et al.
Ronald A Ghossein et al.
High-grade differentiated thyroid carcinoma is a novel classification defined by elevated mitotic count (MC) of ≥5/2 mm2 and/or tumor necrosis. It may assume a phenotype of papillary thyroid carcinoma, diffuse sclerosing subtype (PTC-DS), ...
Clinical Significance of Different Histology and High-Risk HPV Types in Neuroendocrine Carcinomas of the Cervix [0.03%]
宫颈神经内分泌癌不同组织学类型和高危HPV型别的临床意义
Seung Jun Lee,Seokhyun Lee,Ilias P Nikas et al.
Seung Jun Lee et al.
This study aimed to investigate the impact of different histologic and high-risk (HR) human papillomavirus (HPV) types on the clinicopathologic characteristics and survival of patients with neuroendocrine carcinoma of the cervix (NEC). We r...
Comparison of HER2 Scoring Systems in Endometrial Cancer: Toward Optimization of HER2-Directed Therapies [0.03%]
子宫癌中HER2评分系统的比较：优化HER2导向治疗的方向
Ekaterina Menshikova,Kristin Deeb,Elizabeth M Genega et al.
Ekaterina Menshikova et al.
Endometrial carcinomas (EC) show variable HER2 protein expression or gene amplification and may be eligible for HER2-directed therapy (trastuzumab or antibody-drug conjugates (ADCs) such as trastuzumab-deruxtecan). HER2 testing is currently...
Wipawi Klaisuban,Chuying Su,Matthew Koslow et al.
Wipawi Klaisuban et al.
Diagnosing pulmonary rheumatoid nodules (RN) is challenging because they are rare and share clinical, radiologic, and histopathologic features with other necrotizing granulomatous diseases such as infectious granulomas (IG) and granulomatos...
Histopathologic Grading of Residual Tumor Predicts Survival of Intrahepatic Cholangiocarcinoma Patients Treated With Neoadjuvant Therapy: Major Pathologic Response and Its Clinical Significance [0.03%]
残余肿瘤的组织病理分级可预测接受新辅助治疗的肝内胆管癌患者的生存率：主要病理反应及其临床意义
Gaohua Wu,Xiufen Chen,Rongkui Luo et al.
Gaohua Wu et al.
Neoadjuvant therapy (NAT) is increasingly used to treat patients with initially unresectable intrahepatic cholangiocarcinoma (iCCA). A histopathologic grading system for residual tumors that can predict patient survival is lacking in the li...
Pancreatic Serous Neoplasm and Metastatic Clear Cell Renal Cell Carcinoma: Diagnostic Pitfalls Resolvable by a Panel of Immunohistochemical Stains to Include PAX8 and CK7 But Not CAIX [0.03%]
胰腺浆液性肿瘤和转移性透明细胞肾细胞癌：可通过包括PAX8和CK7但不包括CAIX的一组免疫组织化学染色解决的诊断陷阱
Talent Theparee,Sarah E Umetsu,Emily Chan
Talent Theparee
Pancreatic serous neoplasms can morphologically resemble metastatic clear cell renal cell carcinoma (ccRCC) and may present a diagnostic dilemma, particularly if the solid variant is in small biopsy specimens and/or in patients with von Hip...
SMARCB1-deficient Sinonasal Carcinoma: Expanding the Pathologic Spectrum With a Series of 32 Cases [0.03%]
无SMARCB1鼻窦癌：通过32例病例扩大病理范围
Neha Mittal,Saurabh Nagar,Asawari Patil et al.
Neha Mittal et al.
SMARCB1-deficient sinonasal carcinoma (SDSC) is a recently recognized rare malignancy. Despite growing awareness, SDSC remains susceptible to misdiagnosis owing to its rarity and overlapping features with diverse mimics. A retrospective rev...
Enterovirus Placentitis is an Underrecognized Cause of Placental Pathology [0.03%]
肠道病毒胎盘炎是胎盘病理的潜在原因
Andrew P Norgan,Elizabeth Ann L Enninga,Bohdana Fedyshyn et al.
Andrew P Norgan et al.
The placenta is susceptible to infection by a number of viral pathogens, including severe acute respiratory syndrome coronavirus 2, which is associated with poor fetal outcomes. The histologic pattern of injury, termed severe acute respirat...