The American journal of surgical pathology. 2025 Mar 31. doi: 10.1097/PAS.0000000000002395 Q14.52024

CDKN2A Chromogenic In Situ Hybridization for Separating Benign From Malignant Mesothelial Proliferations

用于区分良性与恶性间皮增生的CDKN2A染色原位杂交技术翻译改进

Andrew Churg^{1 2}, Tara Spence^{1 2}, Karina C Martin^{1 2}, Janine Senz², Stephen Yip^{1 2}, Julia R Naso^{1 2}

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作者单位

¹ Department of Pathology and Laboratory Medicine, Vancouver General Hospital.

² Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

DOI: 10.1097/PAS.0000000000002395 PMID: 40160119

摘要 Ai翻译

CDKN2A FISH is a standard method for separating mesotheliomas from reactive mesothelial proliferations, but FISH requires specialized equipment and technical expertise for interpretation. Here, we show that a commercially available CDKN2A CISH probe provides equivalent information but can be easily scored using an ordinary light microscope and does not require specialized training.

Keywords：CDKN2A; Benign

关键词：染色原位杂交; CDKN2A; 良性; 恶性间皮增生

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期刊名：American journal of surgical pathology

缩写：AM J SURG PATHOL

ISSN：0147-5185

e-ISSN：1532-0979

IF/分区：4.5/Q1

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CDKN2A Chromogenic In Situ Hybridization for Separating Benign From Malignant Mesothelial Proliferations

用于区分良性与恶性间皮增生的CDKN2A染色原位杂交技术翻译改进

Role of Cdkn2a in the Emery-Dreifuss Muscular Dystrophy Cardiac Phenotype

Cdkn2a在Emery-Dreifuss肌营养不良心脏表型中的作用

Frequency and Role of CDKN2A Deletion in High-Risk Pituitary Neuroendocrine Tumors

高风险垂体神经内分泌肿瘤中CDKN2A缺失的频率和作用

A comprehensive consolidation of data on the connection between CDKN2A polymorphisms and the susceptibility to childhood acute lymphoblastic leukemia

CDKN2A基因多态性与儿童急性淋巴细胞白血病易感性的相关性汇总分析

Effectiveness and causes for failure of surveillance of CDKN2A-mutated melanoma families

CDKN2A突变型黑色素瘤家系监测的效果及失败原因分析

TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts

TALE介导的CDKN2A表观遗传沉默增加人成纤维细胞的复制能力

Corrigendum to: TET2-mediated Cdkn2A DNA hydroxymethylation in midbrain dopaminergic neuron injury of Parkinson's disease

TET2介导的中脑多巴胺能神经元损伤在帕金森病中的CDKN2A DNA羟甲基化修正意见：TET2介导的中脑多巴胺能神经元损伤在帕金森病中的CDKN2A DNA羟甲基化

The functional role of inherited CDKN2A variants in childhood acute lymphoblastic leukemia

儿童急性淋巴细胞白血病中继承的CDKN2A基因变异的功能作用

Genetic and methylation status of CDKN2A (p14ARF/p16INK4A) and TP53 genes in recurrent respiratory papillomatosis

复发性呼吸道乳头状瘤中CDKN2A（p14ARF / p16INK4A）和TP53基因的遗传学和甲基化状态研究

CDKN2A Chromogenic In Situ Hybridization for Separating Benign From Malignant Mesothelial Proliferations

用于区分良性与恶性间皮增生的CDKN2A染色原位杂交技术 翻译改进

Role of Cdkn2a in the Emery-Dreifuss Muscular Dystrophy Cardiac Phenotype

Cdkn2a在Emery-Dreifuss肌营养不良心脏表型中的作用

Frequency and Role of CDKN2A Deletion in High-Risk Pituitary Neuroendocrine Tumors

高风险垂体神经内分泌肿瘤中CDKN2A缺失的频率和作用

A comprehensive consolidation of data on the connection between CDKN2A polymorphisms and the susceptibility to childhood acute lymphoblastic leukemia

CDKN2A基因多态性与儿童急性淋巴细胞白血病易感性的相关性汇总分析

Effectiveness and causes for failure of surveillance of CDKN2A-mutated melanoma families

CDKN2A突变型黑色素瘤家系监测的效果及失败原因分析

TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts

TALE介导的CDKN2A表观遗传沉默增加人成纤维细胞的复制能力

Corrigendum to: TET2-mediated Cdkn2A DNA hydroxymethylation in midbrain dopaminergic neuron injury of Parkinson's disease

TET2介导的中脑多巴胺能神经元损伤在帕金森病中的CDKN2A DNA羟甲基化修正意见：TET2介导的中脑多巴胺能神经元损伤在帕金森病中的CDKN2A DNA羟甲基化

The functional role of inherited CDKN2A variants in childhood acute lymphoblastic leukemia

儿童急性淋巴细胞白血病中继承的CDKN2A基因变异的功能作用

Genetic and methylation status of CDKN2A (p14ARF/p16INK4A) and TP53 genes in recurrent respiratory papillomatosis

复发性呼吸道乳头状瘤中CDKN2A（p14ARF / p16INK4A）和TP53基因的遗传学和甲基化状态研究

用于区分良性与恶性间皮增生的CDKN2A染色原位杂交技术翻译改进