Papillary Hyperplasia in Autosomal Dominant Polycystic Kidney Disease: A Multi-Institutional Study With Immunohistochemical and Molecular Characterization [0.03%]
autosomal dominant多囊肾病的乳头增生：一项多中心研究及其免疫组化和分子表征
Kara S Tanaka,Sean R Williamson,Nicole Zalles et al.
Kara S Tanaka et al.
Renal cysts in autosomal dominant polycystic kidney disease (ADPKD) frequently harbor small intracystic epithelial proliferations that arise in continuity with the cyst lining and are distinct from other recognized proliferative lesions or ...
DEK::AFF2 Fusion Sinonasal Tract and Skull Base Nonkeratinizing Squamous Cell Carcinoma: An Expanded Single‑Center Series of 50 Cases Extending the Clinicopathologic Spectrum [0.03%]
DEK::AFF2融合鼻腔和颅底非角化鳞状细胞癌：50例单中心系列研究扩展了临床病理学谱系
Changwen Zhai,Hongqin Liu,Jiahao Zhang et al.
Changwen Zhai et al.
DEK::AFF2 fusion‑positive sinonasal tract and skull base nonkeratinizing squamous cell carcinoma (DEK::AFF2 SCC) is a rare and recently recognized entity; however, its clinicopathologic and demographic features remain incompletely defined....
Sporadic Burkitt Lymphoma Lacking MYC Protein Expression: A Rare Entity With Diagnostic Pitfalls and Dismal Prognosis [0.03%]
罕见的Burkitt淋巴瘤缺乏MYC蛋白表达：具有诊断陷阱和预后不良的罕见实体
Xiaoying Lou,Keqi Chen,Mansi Yu et al.
Xiaoying Lou et al.
The pathognomonic genetic alteration in Burkitt lymphoma (BL) is the immunoglobulin (IG)-MYC translocation, causing intense nuclear MYC expression in almost all cases. Rare cases harbor MYC rearrangements yet lack detectable MYC protein exp...
Multifocal Thyroid Follicular Cell-Derived Carcinomas With Discordant Molecular Drivers: Morphologic and Clinical Features in 63 Patients [0.03%]
具有不同分子驱动基因的多焦点甲状腺滤泡细胞来源的癌：63例患者的形态和临床特征分析
Eren Altun,Muhammer Ergenç,Sylvia L Asa
Eren Altun
Thyroid carcinomas of follicular-cell origin are divided into 2 distinct morphologic and molecular families, RAS-like and BRAF p.V600E-like. Multifocality is common, usually of a single type. We retrospectively examined thyroid specimens di...
Metastatic High-Grade Endometrioid Carcinoma to the Lung With Pilomatrix Carcinoma-Like Morphology: Potential for Misdiagnosis as Non-Small Cell Carcinoma [0.03%]
类似皮瘤癌型高grade内膜样腺癌肺转移的误诊为非小细胞肺癌的可能性
Timothy A Dinh,Mary M Torrez,Kristine E Konopka et al.
Timothy A Dinh et al.
Pilomatrix-like high-grade endometrioid carcinoma (PiMHEC) is a recently described aggressive variant of endometrioid carcinoma characterized by solid nests of basaloid cells with abrupt keratinization, geographic necrosis, and anucleated g...
Next-Generation Sequencing of Multivergent Morphologies in Colorectal Carcinomas Identifies Unique Targetable Alterations [0.03%]
结直肠癌多形态学的下一代测序鉴定出独特的可靶向改变
Brent K Larson,Elias Makhoul,Alexandra Gangi et al.
Brent K Larson et al.
Typically, colorectal carcinoma (CRC) is morphologically relatively homogeneous. Uncommon morphologic patterns may be enriched for rare molecular drivers. This study examined the clinicopathologic characteristics of CRC with multivergent mo...
Uterine Leiomyomas Presenting During Pregnancy and Delivery: Comprehensive Characterization of Features Helpful in the Distinction From Malignant Mimics [0.03%]
妊娠和分娩期间出现的子宫平滑肌瘤及其与恶性肿瘤模仿病变的区别特征的全面分析
Ekaterina Olkhov-Mitsel,Yutaka Amemiya,Arun Seth et al.
Ekaterina Olkhov-Mitsel et al.
A subset of uterine leiomyomas becomes clinically apparent during pregnancy/delivery and is typically excised during Cesarean section. Although benign, these leiomyomas excised during pregnancy and/or delivery (LEPs) can pose diagnostic cha...
HOXB13 Is a Sensitive and Specific Diagnostic Marker for Myxopapillary Ependymoma [0.03%]
HOXB13是诊断脊髓黏多糖样乳头状室管膜瘤敏感和特异的标志物
Meng Zhang,Huanli Duan,Wanting Wang et al.
Meng Zhang et al.
Myxopapillary ependymoma (MPE) is a rare spinal tumor that remains undercharacterized in systematic investigations. Accurate distinction from histologic mimics in the conus-cauda-filum terminale region is challenging. This study aimed to de...
Clinicopathological Characterization of Digital Papillary Adenocarcinoma With Emphasis on Low-risk Human Papillomavirus In Situ Hybridization and BRAF-VE1 Immunohistochemistry [0.03%]
重视低风险人乳头瘤病毒原位杂交和BRAF-VE1免疫组化特征的数字化管状腺癌的临床病理研究
Daniel S Alt,Steven M Hrycaj,Simon J Warren et al.
Daniel S Alt et al.
Digital papillary adenocarcinoma (DPA) is a rare malignant sweat gland tumor affecting fingers and toes most commonly. Human papillomavirus type 42 (HPV42), a low-risk HPV type, is an important diagnostic criterion. No uniform mutational si...
EVALI and Beyond: An Update on the Spectrum of Vaping-Associated Lung Pathology [0.03%]
从VAEP到 EVALI：与电子烟相关肺部疾病的光谱病理损害的更新
Peter J Manchen,Brandon T Larsen,Maxwell L Smith et al.
Peter J Manchen et al.
E-cigarette or vaping-associated lung injury (EVALI) was initially recognized as a public health problem in 2019, but pathologic changes from vaping (if any) outside the context of EVALI remain unknown. We aimed to further characterize the ...