Central Pathology Review of Endometrial Hyperplasia and Adenocarcinoma Before and After Treatment With the Levonorgestrel Intrauterine Device-Results From the feMMe Phase 2 Randomized Clinical Trial [0.03%]
左炔诺孕酮宫内节育器治疗子宫内膜增生和腺癌的中央病理审查：feMMe II期随机临床试验结果
Eva Baxter,Kristy P Robledo,Margaret Cummings et al.
Eva Baxter et al.
Distinguishing endometrial hyperplasia from endometrial adenocarcinoma remains a histopathologic challenge. Several retrospective studies have reported high interobserver variability when assessing the progestin-naive endometrium, while onl...
Molecular Relationship Between Ovarian Sertoli-Leydig Cell Tumors and Their Heterologous Elements: Emphasis on the Possible Prognostic Significance of TERT Pathogenic Variants [0.03%]
卵巢Sertoli- Leydig细胞瘤及其异源成分的分子关系：TERT致病突变体可能的预后意义不容忽视
Alexis Trecourt,Clémence Scard,Françoise Descotes et al.
Alexis Trecourt et al.
Since the histogenesis of heterologous elements within Sertoli-Leydig cell tumors (SLCTs) is poorly understood, we aimed to study the molecular relationship between Sertoli cells and the heterologous elements in 16 ovarian SLCTs. We perform...
Performance Assessment of a Deep Learning-based Algorithm for Ovarian Cancer Histotyping in an Independent Data Set [0.03%]
基于深度学习的卵巢癌病理分型算法的独立数据集性能评估
Hein S Zelisse,Maryam Asadi-Aghbolaghi,Hossein Farahani et al.
Hein S Zelisse et al.
Artificial intelligence diagnostic tools show promise for improving histotype classification in epithelial ovarian cancer but face challenges due to slide variability across institutions. To address this domain shift, the adversarial Fourie...
Extrauterine RAD51B-Rearranged Soft Tissue Tumors: A Clinicopathologic and Molecular Genetic Study of 10 Cases With Heterogeneous Morphology, Novel Fusions, and a Distinct Methylation Profile [0.03%]
RAD51B重排的盆腔外软组织肿瘤：10例异质性形态、新型融合及独特的甲基化谱的临床病理和分子遗传研究
Peipei Zhu,Xiaona Yin,Dan Huang et al.
Peipei Zhu et al.
A subset of uterine smooth muscle tumors and PEComas has been recently shown to harbor RAD51B rearrangement. To date, occurrence of RAD51B-rearranged mesenchymal neoplasms in sites outside the uterus is exceedingly rare. In this study, we d...
Pediatric-Type Follicular Lymphoma of the Conjunctiva: Shared Histologic and Molecular Features With the Nodal Counterpart [0.03%]
结膜滤泡性淋巴瘤的儿童型：与相应淋巴结肿瘤的组织病理及分子特征比较
Abdallah Flaifel,Joao Victor Alves de Castro,Shunyou Gong et al.
Abdallah Flaifel et al.
Pediatric-type follicular lymphoma (PTFL) is a rare and indolent B-cell lymphoma that largely affects children and young adults. Although typically nodal, rare similar lesions have been reported in the conjunctiva, but differential diagnosi...
Andrew Churg,Erika Haase,Raheela Siddiqui et al.
Andrew Churg et al.
We report a case of mesothelioma in situ giving rise to invasive mesothelioma and associated with a long in-frame TP53 deletion. Tumor arose in the peritoneal cavity in a 55-year-old man. BAP1, MTAP, and NF2/merlin were retained by immunohi...
Aerogenous Dissemination of DEK::AFF2 Carcinoma: A Prototype of a Previously Underrecognized Pattern of Endobronchial Metastasis From Extrathoracic Malignancies [0.03%]
DEK::AFF2癌的气道播散：外周恶性肿瘤支气管内转移新模式的原型
Eiichi Sasaki,Jen-Fan Hang,Yoshitsugu Horio et al.
Eiichi Sasaki et al.
In this article, we describe a previously underrecognized pattern of aerogenous dissemination to the lungs, based on 2 cases of sinonasal DEK::AFF2 carcinoma. Over follow-up periods of 10 and 18 years, respectively, both patients exhibited ...
MTAP Loss Correlates With Favorable Prognosis in HPV-independent, p16-negative Oropharyngeal Squamous Cell Carcinoma [0.03%]
HPV阴性、p16阴性的口咽鳞癌中，MTAP缺失与良好的预后相关
Hirotaka Hara,Hidetaka Yamamoto,Ryosuke Kuga et al.
Hirotaka Hara et al.
Human papillomavirus (HPV)-independent oropharyngeal squamous cell carcinoma (OPSCC) is an aggressive cancer without established molecular prognosis. CDKN2A (encoding p16) deletion is a common genetic event in HPV-independent OPSCC. CDKN2A ...
A Different Approach to Reporting Prostatic Atypical Intraductal Proliferations: Some Clarifications [0.03%]
关于前列腺导管内不典型增生报告的不同方法：一些澄清事项
Murali Varma,Glen Kristiansen,Gladell P Paner et al.
Murali Varma et al.
Inflammatory Myofibroblastic Tumor of Adults ≥40 Years: A Clinicopathologic Study of 34 Cases [0.03%]
成人≥40岁炎性肌纤维母细胞瘤34例临床病理学研究
Ahmed Bakhshwin,Susan Armstrong,Lauren Duckworth et al.
Ahmed Bakhshwin et al.
Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm with a predilection for children and adolescents. Data regarding IMTs in adulthood is limited, and evidence suggests that ALK expression/rearrangement rate decreases wi...