Multifocal Thyroid Follicular Cell-Derived Carcinomas With Discordant Molecular Drivers: Morphologic and Clinical Features in 63 Patients [0.03%]
具有不同分子驱动基因的多焦点甲状腺滤泡细胞来源的癌：63例患者的形态和临床特征分析
Eren Altun,Muhammer Ergenç,Sylvia L Asa
Eren Altun
Thyroid carcinomas of follicular-cell origin are divided into 2 distinct morphologic and molecular families, RAS-like and BRAF p.V600E-like. Multifocality is common, usually of a single type. We retrospectively examined thyroid specimens di...
Metastatic High-Grade Endometrioid Carcinoma to the Lung With Pilomatrix Carcinoma-Like Morphology: Potential for Misdiagnosis as Non-Small Cell Carcinoma [0.03%]
类似皮瘤癌型高grade内膜样腺癌肺转移的误诊为非小细胞肺癌的可能性
Timothy A Dinh,Mary M Torrez,Kristine E Konopka et al.
Timothy A Dinh et al.
Pilomatrix-like high-grade endometrioid carcinoma (PiMHEC) is a recently described aggressive variant of endometrioid carcinoma characterized by solid nests of basaloid cells with abrupt keratinization, geographic necrosis, and anucleated g...
Next-Generation Sequencing of Multivergent Morphologies in Colorectal Carcinomas Identifies Unique Targetable Alterations [0.03%]
结直肠癌多形态学的下一代测序鉴定出独特的可靶向改变
Brent K Larson,Elias Makhoul,Alexandra Gangi et al.
Brent K Larson et al.
Typically, colorectal carcinoma (CRC) is morphologically relatively homogeneous. Uncommon morphologic patterns may be enriched for rare molecular drivers. This study examined the clinicopathologic characteristics of CRC with multivergent mo...
Uterine Leiomyomas Presenting During Pregnancy and Delivery: Comprehensive Characterization of Features Helpful in the Distinction From Malignant Mimics [0.03%]
妊娠和分娩期间出现的子宫平滑肌瘤及其与恶性肿瘤模仿病变的区别特征的全面分析
Ekaterina Olkhov-Mitsel,Yutaka Amemiya,Arun Seth et al.
Ekaterina Olkhov-Mitsel et al.
A subset of uterine leiomyomas becomes clinically apparent during pregnancy/delivery and is typically excised during Cesarean section. Although benign, these leiomyomas excised during pregnancy and/or delivery (LEPs) can pose diagnostic cha...
HOXB13 Is a Sensitive and Specific Diagnostic Marker for Myxopapillary Ependymoma [0.03%]
HOXB13是诊断脊髓黏多糖样乳头状室管膜瘤敏感和特异的标志物
Meng Zhang,Huanli Duan,Wanting Wang et al.
Meng Zhang et al.
Myxopapillary ependymoma (MPE) is a rare spinal tumor that remains undercharacterized in systematic investigations. Accurate distinction from histologic mimics in the conus-cauda-filum terminale region is challenging. This study aimed to de...
Clinicopathological Characterization of Digital Papillary Adenocarcinoma With Emphasis on Low-risk Human Papillomavirus In Situ Hybridization and BRAF-VE1 Immunohistochemistry [0.03%]
重视低风险人乳头瘤病毒原位杂交和BRAF-VE1免疫组化特征的数字化管状腺癌的临床病理研究
Daniel S Alt,Steven M Hrycaj,Simon J Warren et al.
Daniel S Alt et al.
Digital papillary adenocarcinoma (DPA) is a rare malignant sweat gland tumor affecting fingers and toes most commonly. Human papillomavirus type 42 (HPV42), a low-risk HPV type, is an important diagnostic criterion. No uniform mutational si...
EVALI and Beyond: An Update on the Spectrum of Vaping-Associated Lung Pathology [0.03%]
从VAEP到 EVALI：与电子烟相关肺部疾病的光谱病理损害的更新
Peter J Manchen,Brandon T Larsen,Maxwell L Smith et al.
Peter J Manchen et al.
E-cigarette or vaping-associated lung injury (EVALI) was initially recognized as a public health problem in 2019, but pathologic changes from vaping (if any) outside the context of EVALI remain unknown. We aimed to further characterize the ...
Proteomic Analysis Identifies Potential Biomarkers of ELOC-Mutated Renal Cell Carcinoma [0.03%]
蛋白质组学分析鉴定出ELOC突变型肾细胞癌的潜在生物标志物
Akihiko Fukagawa,Yasuhito Arai,Akiko Maeshima et al.
Akihiko Fukagawa et al.
ELOC-mutated renal cell carcinoma (RCC) is a rare tumor with only ∼40 cases reported to date; it shares a molecular background with clear cell RCC (ccRCC) in terms of hypoxia-inducible factor-alpha (HIF-α) protein accumulation. ELOC-mutat...
Limited Availability of Short Tandem Repeat Genotype Testing in the United States for Diagnosis of Partial Hydatidiform Mole: A Dilemma for Practicing Precision Medicine [0.03%]
美国限制使用短串联重复序列基因分型检测诊断部分水泡状胎块的现状：精准医疗面临的难题
Laura Warren,Laura J Tafe,W Patrick Devine et al.
Laura Warren et al.
The pathogenetic definition of a partial hydatidiform mole (PHM) is a diandric triploid gestation, thereby requiring short tandem repeat (STR) genotype testing for definitive diagnosis in formalin-fixed products of conception (POC) specimen...
Clinicopathologic Analysis of 43 Surgically Resected Lactotroph Pituitary Neuroendocrine Tumors Stratified by Surgical Indication: A Pathologic Reappraisal of Apparent Male Aggressiveness [0.03%]
基于手术适应证分层的43例手术切除泌乳素分泌垂体神经内分泌肿瘤的临床病理分析：对男性易感性的病理再评价
Noriaki Tanabe,Naoko Inoshita,Eri Kasuga et al.
Noriaki Tanabe et al.
Male lactotroph pituitary neuroendocrine tumors (PitNETs) are often considered more aggressive than those in women, but surgically treated cohorts are highly selected and may reflect differences in presentation and indication for surgery. W...